Other Name(s): Rac, Akt, AKT
Assay:Inhibition of PKBalpha (Akt1) ser/thr kinase.
Type:IC50
SMILES:O=C(Nc1ccccn1)Nc1cccc2c1[C@H]1CCCN1C2=O
Value:>10000nM
Source:Homo sapiens
Assay:Inhibition of Protein kinase B, Akt-1
Type:IC50
SMILES:Cn1ccc2ccc3c4[nH]c5c(CCCN[C@H]6CC[C@H](O)CC6)cccc5c4c4c(c3c21)C(=O)NC4=O
Value:=5480nM
Source:
Assay:Inhibition of Protein kinase B (Akt-1)
Type:IC50
SMILES:O=C(Cc1ccc2ccccc2c1)Nc1cc(C2CC2)n[nH]1
Value:>10000nM
Source:
Assay:Inhibition of Protein kinase B alpha
Type:IC50
SMILES:COc1ccc(O)c(C(=O)c2ccc(C(=O)O[C@@H]3CCCNCC3NC(=O)c3ccncc3)cc2)c1F.Cl.Cl
Value:=5nM
Source:
Assay:Inhibition of Protein kinase B alpha
Type:IC50
SMILES:COc1ccc(O)c(C(=O)c2ccc(/C=C/[C@@H]3CCCNC[C@H]3NC(=O)c3ccncc3)cc2)c1F.Cl
Value:=160nM
Source:
Assay:Inhibition of Protein kinase B alpha
Type:IC50
SMILES:COc1ccc(O)c(C(=O)c2ccc(CO[C@@H]3CCCNCC3NC(=O)c3ccncc3)cc2)c1F.Cl.Cl
Value:=355nM
Source:
Assay:Inhibition of Protein kinase B alpha
Type:IC50
SMILES:COc1ccc(O)c(C(=O)c2ccc(C(=O)N[C@@H]3CCCNCC3NC(=O)c3ccncc3)cc2)c1F.Cl.Cl
Value:=4nM
Source:
Assay:Inhibition of Protein kinase B alpha
Type:IC50
SMILES:COc1ccc(O)c(C(=O)c2ccc(NC[C@@H]3CCCNCC3NC(=O)c3ccncc3)cc2)c1F.Cl
Value:=25000nM
Source:
Assay:Inhibition of Protein kinase B alpha
Type:IC50
SMILES:COc1ccc(O)c(C(=O)c2ccc(CN[C@@H]3CCCNC[C@H]3NC(=O)c3ccncc3)cc2)c1F.Cl
Value:=3000nM
Source:
Assay:Inhibition of Protein kinase B alpha
Type:IC50
SMILES:CCN(CC)C/C=C/c1nc(O)c2c(ccc3nc(Nc4c(Cl)cccc4Cl)n(C)c32)c1C
Value:>1000nM
Source:
Assay:Inhibition constant for protein kinase B alpha (Akt1) in fluorescent enzymatic assay
Type:Ki
SMILES:CC1=C(C#N)c2nc(N)c(C#N)c(C)c2/C1=C/c1ccc(-c2ccc(C(=O)O)c(Cl)c2)o1
Value:=1100nM
Source:
Assay:Inhibition constant for protein kinase B alpha (Akt1) in fluorescent enzymatic assay
Type:Ki
SMILES:O=C(/C=C/c1nc2ccccc2[nH]1)c1c(O)nc2ccc(Cl)cc2c1-c1ccccc1
Value:=3900nM
Source:
Assay:Inhibition constant for protein kinase B alpha (Akt1) in fluorescent enzymatic assay
Type:Ki
SMILES:O=C(O)c1cc(-c2ccc(C=C3C(=O)c4ccccc4C3=O)o2)ccc1O
Value:=20800nM
Source:
Assay:Inhibition constant for protein kinase B alpha (Akt1) in fluorescent enzymatic assay
Type:Ki
SMILES:O=S(=O)(NCCNC/C=C/c1ccc(Br)cc1)c1cccc2cnccc12
Value:=4500nM
Source:
Assay:Inhibition of AKT kinase
Type:IC50
SMILES:N#C/C(=C1/Nc2ccccc2S1)c1ccnc(NCCc2cccnc2)n1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Value:>10000nM
Source:
Assay:Inhibition of human Akt1
Type:IC50
SMILES:CC(C)OC(=O)N1CCn2cc(C3=C(c4cnc5ccccn45)C(=O)NC3=O)c3cccc(c32)C1
Value:>20000nM
Source:Homo sapiens
Assay:Inhibition of human Akt1
Type:IC50
SMILES:O=C1NC(=O)C(c2cnc3ccccn23)=C1c1cn2c3c(cccc13)CN(C(=O)N1CCCCC1)CC2
Value:>20000nM
Source:Homo sapiens
Assay:Inhibition of human Akt1
Type:IC50
SMILES:Cc1cc2c3c(c1)c(C1=C(c4cnc5ccccn45)C(=O)NC1=O)cn3CCN(C(=O)N1CCCCC1)C2
Value:>20000nM
Source:Homo sapiens
Assay:Inhibition of human Akt1
Type:IC50
SMILES:O=C1NC(=O)C(c2cnc3ccccn23)=C1c1cn2c3c(cccc13)CN(C(=O)N1CCOCC1)CC2
Value:>20000nM
Source:Homo sapiens
Assay:Inhibition of human Akt1
Type:IC50
SMILES:CN(C)C(=O)N1CCn2cc(C3=C(c4cnc5ccccn45)C(=O)NC3=O)c3cccc(c32)C1
Value:>20000nM
Source:Homo sapiens

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ABCB1 | ABCG2 | ACE2 | AHR | AKT1 | ALK | AR | ATM | BAX | BCL2 | BCL2L1 | BRAF | BRCA1 | CASP3 | CASP9 | CCL5 | CCND1 | CD274 | CD4 | CDKN1A | CXCL8 | CXCR4 | DNMT1 | EGF | EGFR | EP300 | ERBB2 | ESR1 | EZH2 | FN1 | FOXO3 | HDAC9 | HGF | HMGB1 | HSP90AA1 | HSPA5 | IDO1 | IGF1 | IGF1R | IL17A | IL6 | INS | JUN | KRAS | MAPK1 | MAPK14 | MAPK3 | MAPK8 | MAPT | MCL1 | MMP9 | MTOR | MYC | NFE2L2 | NLRP3 | NOTCH1 | PARP1 | PCNA | PDCD1 | PLK1 | PRKAA1 | PRKAA2 | PTEN | PTGS2 | PTK2 | RELA | SIRT1 | SRC | STAT1 | STAT3 | STAT5A | TERT | TLR4 | TNF | TP53 | TXN | VEGFA | YAP1