Other Name(s): FAK, Focal Adhesion Kinase
Assay:Inhibition of FAK kinase
Type:IC50
SMILES:Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1
Value:>25000nM
Source:
Assay:Inhibition of FAK, focal adhesion kinase
Type:IC50
SMILES:CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1
Value:>40000nM
Source:
Assay:In vitro inhibitory concentration against FAK with ATP concentration at 1/2Km
Type:IC50
SMILES:Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NC[C@@H](O)c4cccc(Cl)c4)cc[nH]c3=O)nc12
Value:=150nM
Source:Homo sapiens
Assay:Inhibitory concentration against FAK cytoplasmic sequence; Reported as mean (variability <15%)
Type:IC50
SMILES:CCc1c(NC(=O)OCCn2ccnc2)cn2ncnc(Nc3ccc4c(cnn4Cc4ccccc4)c3)c12
Value:>25000nM
Source:Homo sapiens
Assay:Average Binding Constant for PTK2; NA=Not Active at 10 uM
Type:Kd
SMILES:CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C
Value:=4400nM
Source:Homo sapiens
Assay:Average Binding Constant for PTK2; NA=Not Active at 10 uM
Type:Kd
SMILES:CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C
Value:=610nM
Source:Homo sapiens
Assay:Average Binding Constant for PTK2; NA=Not Active at 10 uM
Type:Kd
SMILES:CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4
Value:=68nM
Source:Homo sapiens
Assay:Inhibitory activity against FAK
Type:IC50
SMILES:COc1cc2c(cc1OC)-c1n[nH]c(Nc3cccc(F)c3)c1C2
Value:>100000nM
Source:
Assay:Inhibitory activity against FAK
Type:IC50
SMILES:COc1cc2c(Nc3ncc(CC(=O)Nc4cccc(F)c4)s3)ncnc2cc1OCCCN1CCC(CO)CC1
Value:=4000nM
Source:
Assay:Inhibitory activity against FAK
Type:IC50
SMILES:COc1cc(Nc2ncc(Br)c(Nc3ccccn3)n2)cc(OC)c1OC
Value:=100nM
Source:Homo sapiens
Assay:Inhibitory activity against FAK
Type:IC50
SMILES:COc1cc(Nc2ncc3ccc(=O)n(-c4ccccn4)c3n2)cc(OC)c1OC
Value:>10000nM
Source:Homo sapiens
Assay:Inhibitory activity against FAK
Type:IC50
SMILES:COc1cc(Nc2ncc3c(n2)N(c2ccccn2)CCC3)cc(OC)c1OC
Value:=200nM
Source:Homo sapiens
Assay:Inhibitory activity against FAK
Type:IC50
SMILES:COc1cc(Nc2ncc3c(n2)N(c2ccccn2)C(O)CC3)cc(OC)c1OC
Value:=200nM
Source:Homo sapiens
Assay:Inhibitory activity against FAK
Type:IC50
SMILES:COc1cc(Nc2ncc3c(n2)N(c2ccccn2)C(=O)CC3)cc(OC)c1OC
Value:>10000nM
Source:Homo sapiens
Assay:Inhibitory activity against FAK
Type:IC50
SMILES:COc1cc(Nc2ncc3c(n2)N(c2ccccn2)CC3)cc(OC)c1OC
Value:=100nM
Source:Homo sapiens
Assay:Inhibitory activity against FAK
Type:IC50
SMILES:COc1cc(Nc2ncc3c(n2)N(c2ccccn2)C(=O)C3)cc(OC)c1OC
Value:>10000nM
Source:Homo sapiens
Assay:Inhibitory activity against FAK
Type:IC50
SMILES:CCOC(=O)Cc1cnc(Nc2cc(OC)c(OC)c(OC)c2)nc1Nc1ccccn1
Value:=200nM
Source:Homo sapiens
Assay:Inhibitory activity against FAK
Type:IC50
SMILES:CCOC(=O)Cc1cnc(Nc2cc(OC)c(OC)c(OC)c2)nc1Cl
Value:>10000nM
Source:Homo sapiens
Assay:Inhibitory activity against FAK
Type:IC50
SMILES:COc1cc(Nc2ncc3ccn(-c4ccc(C)cn4)c3n2)cc(OC)c1OC
Value:>10000nM
Source:Homo sapiens
Assay:Inhibitory activity against FAK
Type:IC50
SMILES:COc1cc(Nc2ncc3ccn(-c4ccnc(Cl)c4)c3n2)cc(OC)c1OC
Value:=800nM
Source:Homo sapiens

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