Other Name(s): FOXO3a
Assay:Binding affinity to His-tagged FOXO3a (unknown origin) by SPR analysis
Type:Kd
SMILES:COc1cc([C@H]2OC[C@@H]3[C@@H](c4cc(OC)c(O)c(OC)c4)OC[C@H]23)cc(OC)c1O
Value:=1730000nM
Source:Homo sapiens
Assay:Concentration of the compound required for inhibition of FKHRL1 phosphorylation in human PC3 cell line by IP and WB method; Range = 10-40 uM
Type:Concentration
SMILES:OC1=CC(O)=C2C(=O)C=C(OC2=C1)C3=CC=C(O)C(O)=C3
Value:=40uM
Source:Human
Assay:Activation concentration of compound against Phosphorylation mutant FORKHEAD BOX O3A H212R in U2OS cell line upon incubation for 30 mins by HOECHST 33342 ASSAY
Type:AC50
SMILES:[H][C@@]12CC(CC3=CC=C(C=C3)C3=CC=C(CC4=CC=C(C=C4)N4N=C(N=C4C)C(N)=O)C=C3)C[C@]1([H])CN(C)C2
Value:=0.114uM
Source:
Assay:Activation concentration of compound against Phosphorylation mutant FORKHEAD BOX O3A H212R in U2OS cell line upon incubation for 30 mins by HOECHST 33342 ASSAY
Type:AC50
SMILES:CN(C)C1CCN(CC2=CC=C(C=C2)C2=CC=C(CC3=CC=C(C=C3)N3N=C(C=C3C)C(N)=O)C=C2)CC1
Value:=0.032uM
Source:
Assay:Activation concentration of compound against Phosphorylation mutant FORKHEAD BOX O3A H212R in U2OS cell line upon incubation for 30 mins by HOECHST 33342 ASSAY
Type:AC50
SMILES:CC1=NC(=NN1C1=CC=C(CC2=CC=C(C=C2)C2=CC=C(CN3CCC[C@H]3CO)C=C2)C=C1)C(N)=O
Value:=0.048uM
Source:
Assay:Activation concentration of compound against Phosphorylation mutant FORKHEAD BOX O3A H212R in U2OS cell line upon incubation for 30 mins by HOECHST 33342 ASSAY
Type:AC50
SMILES:CC1=NC(=NN1C1=CC=C(CC2=CC=C(C=C2)C2=CC=C(CN3CCC4(CCO4)CC3)C=C2)C=C1)C(N)=O
Value:=0.081uM
Source:
Assay:Activation concentration of compound against Phosphorylation mutant FORKHEAD BOX O3A H212R in U2OS cell line upon incubation for 30 mins by HOECHST 33342 ASSAY
Type:AC50
SMILES:CC1=NC(=NN1C1=CC=C(CC2=CC=C(C=C2)C2=CC=C(CN3CC(CO)C3)C=C2)C=C1)C(N)=O
Value:=0.164uM
Source:
Assay:Activation concentration of compound against Phosphorylation mutant FORKHEAD BOX O3A H212R in U2OS cell line upon incubation for 30 mins by HOECHST 33342 ASSAY
Type:AC50
SMILES:CC1=NC(=NN1C1=CC=C(CC2=CC=C(C=C2)C2=CC=C(CN3CCC(CC3)C(F)(F)F)C=C2)C=C1)C(N)=O
Value:=0.145uM
Source:
Assay:Activation concentration of compound against Phosphorylation mutant FORKHEAD BOX O3A H212R in U2OS cell line upon incubation for 30 mins by HOECHST 33342 ASSAY
Type:AC50
SMILES:CC1=NC(=NN1C1=CC=C(CC2=CC=C(C=C2)C2=CC=C(CN3C[C@H]4[C@H](CO)[C@H]4C3)C=C2)C=C1)C(N)=O
Value:=0.01uM
Source:
Assay:Activation concentration of compound against Phosphorylation mutant FORKHEAD BOX O3A H212R in U2OS cell line upon incubation for 30 mins by HOECHST 33342 ASSAY
Type:AC50
SMILES:CC1=NC(=NN1C1=CC=C(CC2=CC=C(C=C2)C2=CC=C(CN3CC(F)(F)C3)C=C2)C=C1)C(N)=O
Value:=0.042uM
Source:
Assay:Activation concentration of compound against Phosphorylation mutant FORKHEAD BOX O3A H212R in U2OS cell line upon incubation for 30 mins by HOECHST 33342 ASSAY
Type:AC50
SMILES:CC1=NC(=NN1C1=CC=C(CC2=CC=C(C=C2)C2=CC=C(CN3CCS(=O)(=O)CC3)C=C2)C=C1)C(N)=O
Value:=0.048uM
Source:
Assay:Activation concentration of compound against Phosphorylation mutant FORKHEAD BOX O3A H212R in U2OS cell line upon incubation for 30 mins by HOECHST 33342 ASSAY
Type:AC50
SMILES:CC1=NC(=NN1C1=CC=C(CC2=CC=C(C=C2)C2=CC=C(CN3CCC(CC3)S(C)(=O)=O)C=C2)C=C1)C(N)=O
Value:=0.049uM
Source:
Assay:Activation concentration of compound against Phosphorylation mutant FORKHEAD BOX O3A H212R in U2OS cell line upon incubation for 30 mins by HOECHST 33342 ASSAY
Type:AC50
SMILES:CN1CC[C@@H]2CN(CC3=CC=C(C=C3)C3=CC=C(CC4=CC=C(C=C4)N4N=C(N=C4C)C(N)=O)C=C3)C[C@H]12
Value:=0.032uM
Source:
Assay:Activation concentration of compound against Phosphorylation mutant FORKHEAD BOX O3A H212R in U2OS cell line upon incubation for 30 mins by HOECHST 33342 ASSAY
Type:AC50
SMILES:CC1=NC(=NN1C1=CC=C(CC2=CC=C(C=C2)C2=CC=C(CN3C[C@H](O)[C@@H](O)C3)C=C2)C=C1)C(N)=O
Value:=0.18uM
Source:
Assay:Activation concentration of compound against Phosphorylation mutant FORKHEAD BOX O3A H212R in U2OS cell line upon incubation for 30 mins by HOECHST 33342 ASSAY
Type:AC50
SMILES:CN1CCCN(CC2=CC=C(C=C2)C2=CC=C(CC3=CC=C(C=C3)N3N=C(N=C3C)C(N)=O)C=C2)CC1
Value:=0.039uM
Source:
Assay:Activation concentration of compound against Phosphorylation mutant FORKHEAD BOX O3A H212R in U2OS cell line upon incubation for 30 mins by HOECHST 33342 ASSAY
Type:AC50
SMILES:CC1=NC(=NN1C1=CC=C(C=C1)C(C)(C)C1=CC=C(C=C1)C1=CC=C(CN2CCCC2)C=C1)C(N)=O
Value:=0.128uM
Source:
Assay:Activation concentration of compound against Phosphorylation mutant FORKHEAD BOX O3A H212R in U2OS cell line upon incubation for 30 mins by HOECHST 33342 ASSAY
Type:AC50
SMILES:CC1=CC(=NN1C1=CC=C(C=C1)C(C)(C)C1=CC=C(C=C1)C1=CC=C(C=C1)C1(CN)COC1)C(N)=O
Value:=0.607uM
Source:
Assay:Activation concentration of compound against Phosphorylation mutant FORKHEAD BOX O3A H212R in U2OS cell line upon incubation for 30 mins by HOECHST 33342 ASSAY
Type:AC50
SMILES:CC1=CC(=NN1C1=CC=C(C=C1)C(C)(C)C1=CC=C(C=C1)C1=CCC(O)CC1)C(N)=O
Value:=0.253uM
Source:
Assay:Activation concentration of compound against Phosphorylation mutant FORKHEAD BOX O3A H212R in U2OS cell line upon incubation for 30 mins by HOECHST 33342 ASSAY
Type:AC50
SMILES:CC1=CC(=NN1C1=CC=C(C=C1)C(C)(C)C1=CC=C(C=C1)C1=CCC(=O)CC1)C(N)=O
Value:=0.058uM
Source:
Assay:Activation concentration of compound against Phosphorylation mutant FORKHEAD BOX O3A H212R in U2OS cell line upon incubation for 30 mins by HOECHST 33342 ASSAY
Type:AC50
SMILES:CC1=CC(=NN1C1=CC=C(C=C1)C(C)(C)C1=CC=C(C=C1)C1=CC(N)=NC=C1)C(N)=O
Value:=0.134uM
Source:

Note: If you'd like to learn how our AI-powered BDE-Chem can help design therapeutic molecules against the FOXO3 target, that break through the existing patents, at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai

Molecules for More Common Targets

ABCB1 | ABCG2 | ACE2 | AHR | AKT1 | ALK | AR | ATM | BAX | BCL2 | BCL2L1 | BRAF | BRCA1 | CASP3 | CASP9 | CCL5 | CCND1 | CD274 | CD4 | CDKN1A | CXCL8 | CXCR4 | DNMT1 | EGF | EGFR | EP300 | ERBB2 | ESR1 | EZH2 | FN1 | FOXO3 | HDAC9 | HGF | HMGB1 | HSP90AA1 | HSPA5 | IDO1 | IGF1 | IGF1R | IL17A | IL6 | INS | JUN | KRAS | MAPK1 | MAPK14 | MAPK3 | MAPK8 | MAPT | MCL1 | MMP9 | MTOR | MYC | NFE2L2 | NLRP3 | NOTCH1 | PARP1 | PCNA | PDCD1 | PLK1 | PRKAA1 | PRKAA2 | PTEN | PTGS2 | PTK2 | RELA | SIRT1 | SRC | STAT1 | STAT3 | STAT5A | TERT | TLR4 | TNF | TP53 | TXN | VEGFA | YAP1