Other Name(s): P38 Mitogen-activated Protein Kinase, P38, P38
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:Cn1c(=O)n(C)c2cc(-c3[nH]c(-c4cccs4)nc3-c3cccc(C(F)(F)F)c3)ccc21
Value:=1500nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:CCn1c(=O)n(CC)c2cc(-c3cc(-c4cccnc4)[nH]c3-c3cccc(C)c3)ccc21
Value:>1000nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:Cn1c(=O)n(C)c2cc(-c3c[nH]nc3-c3ccccc3)ccc21
Value:=200nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:CCn1c(=O)n(CC)c2cc(-c3ocnc3-c3cccc(C)c3)ccc21
Value:=800nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:Cn1c(=O)n(C)c2cc(-c3[nH]c(-c4cccs4)nc3-c3cccc(Cl)c3)ccc21
Value:=380nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:CCn1c(=O)n(CC)c2cc(-c3c[nH]nc3-c3ccccc3)ccc21
Value:=200nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:C[C@H](Nc1cc(-c2c(-c3cccc(C(F)(F)F)c3)nc(C3CCNCC3)n2C)ccn1)c1ccccc1
Value:=2nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:CCn1c(=O)n(CC)c2cc(-c3[nH]cnc3-c3ccc(F)cc3)ccc21
Value:=100nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:Cn1c(=O)n(C)c2cc(-c3[nH]c(-c4cccs4)nc3-c3ccccc3)ccc21
Value:=260nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:CC(C)c1cccc(-c2[nH]c(-c3cccs3)nc2-c2ccc3c(c2)n(C)c(=O)n3C)c1
Value:>32000nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:CCn1c(=O)n(CC)c2cc(-c3[nH]ncc3-c3cccc(C)c3)ccc21
Value:=730nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:Cn1c(=O)n(C)c2cc(-c3[nH]c(-c4cccs4)nc3-c3ccccc3Cl)ccc21
Value:=540nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:Cc1ccccc1-c1nc(-c2cccs2)[nH]c1-c1ccc2c(c1)n(C)c(=O)n2C
Value:=6200nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:CCn1c(=O)n(CC)c2cc(-n3nnnc3-c3ccc(F)c(C)c3)ccc21
Value:>1000nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:CCn1c(=O)n(CC)c2cc(-c3c[nH]cn3)ccc21
Value:>1000nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:Cn1c(=O)n(C)c2cc(-c3[nH]c(-c4cccs4)nc3-c3cccc(F)c3)ccc21
Value:=390nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:COc1cc(N)[nH]c2nc(-c3ccc(F)cc3)c(-c3ccncc3)c1-2
Value:=52nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:CCn1c(=O)n(CC)c2cc(-c3c(-c4ccc(F)cc4)ncn3C3CCNCC3)ccc21
Value:=90nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:Cn1c(=O)n(C)c2cc(-c3[nH]c(-c4cccs4)nc3-c3ccc(F)cc3)ccc21
Value:=270nM
Source:
Assay:Inhibitory activity against mitogen activated protein (MAP) kinase p38 alpha.
Type:IC50
SMILES:Cc1cccc(-c2[nH]c3nc(N)ccc3c2-c2ccc3c(c2)n(C)c(=O)n3C)c1
Value:=260nM
Source:

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