Other Name(s): P300
Assay:Inhibition of GST-p300 HAT assessed as histone acetylation
Type:IC50
SMILES:O=C1/C(=C/c2ccc(O)c(C(=O)O)c2)CCC/C1=C\c1ccc(O)c(C(=O)O)c1
Value:=168000nM
Source:Homo sapiens
Assay:Inhibition of GST-p300 HAT assessed as histone acetylation
Type:IC50
SMILES:O=C1/C(=C/c2ccc(O)c(O)c2)CCC/C1=C\c1ccc(O)c(O)c1
Value:=233000nM
Source:Homo sapiens
Assay:Inhibition of GST-p300 HAT assessed as histone acetylation
Type:IC50
SMILES:O=C(/C=C(O)/C=C/c1ccc(O)c(Br)c1)/C=C/c1ccc(O)c(Br)c1
Value:=33000nM
Source:Homo sapiens
Assay:Inhibition of GST-p300 HAT assessed as histone acetylation
Type:IC50
SMILES:O=C(/C=C(O)/C=C/c1ccc(O)c(O)c1)/C=C/c1ccc(O)c(O)c1
Value:=46000nM
Source:Homo sapiens
Assay:Inhibition of GST-p300 HAT assessed as histone acetylation
Type:IC50
SMILES:O=C(/C=C(O)/C=C/c1ccc(O)c(C(=O)O)c1)/C=C/c1ccc(O)c(C(=O)O)c1
Value:=21000nM
Source:Homo sapiens
Assay:Inhibition of GST-p300 HAT assessed as histone acetylation
Type:IC50
SMILES:O=C1/C(=C/c2ccc(O)c(Br)c2)CCC/C1=C\c1ccc(O)c(Br)c1
Value:=5000nM
Source:Homo sapiens
Assay:Inhibition of GST-p300 HAT assessed as histone acetylation
Type:IC50
SMILES:COc1cc(/C=C2\CCC/C(=C\c3ccc(O)c(OC)c3)C2=O)ccc1O
Value:=111000nM
Source:Homo sapiens
Assay:Inhibition of GST-p300 HAT assessed as histone acetylation
Type:IC50
SMILES:COc1cc(/C=C/C(=O)/C=C(O)/C=C/c2ccc(O)c(OC)c2)ccc1O
Value:>400000nM
Source:Homo sapiens
Assay:Inhibition of recombinant His-tagged HAT p300 expressed in Sf21-Baculovirus system
Type:IC50
SMILES:C=CC/C=C\C/C=C\CCCCCCCc1cccc(O)c1C(=O)O
Value:=5000nM
Source:
Assay:Inhibition of HAT p300
Type:IC50
SMILES:C=C(C)[C@@H](CC=C(C)C)C[C@@]12C[C@@H](CC=C(C)C)C(C)(C)[C@@](CC=C(C)C)(C(=O)C(C(=O)c3ccc(O)c(O)c3)=C1O)C2=O
Value:=6000nM
Source:
Assay:Inhibition of GST-fused recombinant HAT p300 expressed in Escherichia coli by filter assay
Type:IC50
SMILES:O=c1ccsn1-c1ccccc1
Value:=23000nM
Source:
Assay:Inhibition of GST-fused recombinant HAT p300 expressed in Escherichia coli by filter assay
Type:IC50
SMILES:O=c1ccsn1-c1ccccn1
Value:=28000nM
Source:
Assay:Inhibition of GST-fused recombinant HAT p300 expressed in Escherichia coli by filter assay
Type:IC50
SMILES:O=c1ccsn1-c1cccnc1
Value:=14400nM
Source:
Assay:Inhibition of GST-fused recombinant HAT p300 expressed in Escherichia coli by filter assay
Type:IC50
SMILES:O=c1ccsn1-c1ccncc1
Value:=3000nM
Source:
Assay:Inhibition of GST-fused recombinant HAT p300 expressed in Escherichia coli by filter assay
Type:IC50
SMILES:O=c1ccsn1-c1ccc(N2CCOCC2)cc1
Value:=9900nM
Source:
Assay:Inhibition of recombinant p300
Type:IC50
SMILES:CC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)(O)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)O
Value:=2880nM
Source:
Assay:Inhibition of recombinant p300
Type:IC50
SMILES:CC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)(O)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)O
Value:=8150nM
Source:
Assay:Inhibition of recombinant p300
Type:IC50
SMILES:CC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)(O)O)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)O
Value:=4350nM
Source:
Assay:Inhibition of recombinant p300
Type:IC50
SMILES:CC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)(O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)O
Value:=6620nM
Source:
Assay:Inhibition of recombinant p300
Type:IC50
SMILES:CC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)(O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)O)[C@H](C)O
Value:=17350nM
Source:

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ABCB1 | ABCG2 | ACE2 | AHR | AKT1 | ALK | AR | ATM | BAX | BCL2 | BCL2L1 | BRAF | BRCA1 | CASP3 | CASP9 | CCL5 | CCND1 | CD274 | CD4 | CDKN1A | CXCL8 | CXCR4 | DNMT1 | EGF | EGFR | EP300 | ERBB2 | ESR1 | EZH2 | FN1 | FOXO3 | HDAC9 | HGF | HMGB1 | HSP90AA1 | HSPA5 | IDO1 | IGF1 | IGF1R | IL17A | IL6 | INS | JUN | KRAS | MAPK1 | MAPK14 | MAPK3 | MAPK8 | MAPT | MCL1 | MMP9 | MTOR | MYC | NFE2L2 | NLRP3 | NOTCH1 | PARP1 | PCNA | PDCD1 | PLK1 | PRKAA1 | PRKAA2 | PTEN | PTGS2 | PTK2 | RELA | SIRT1 | SRC | STAT1 | STAT3 | STAT5A | TERT | TLR4 | TNF | TP53 | TXN | VEGFA | YAP1