Other Name(s): Bip, GRP78, BiP
Assay:Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis
Type:Kd
SMILES:Nc1ncnc2c1nc(N)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Value:=6800nM
Source:
Assay:Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis
Type:Kd
SMILES:Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O
Value:=2170nM
Source:
Assay:Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis
Type:Kd
SMILES:CNc1nc2c(N)ncnc2n1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Value:=7460nM
Source:
Assay:Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis
Type:Kd
SMILES:CNc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COCc2ccccc2)[C@@H](O)[C@H]1O
Value:=990nM
Source:
Assay:Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis
Type:Kd
SMILES:CNc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COCC2CCCCC2)[C@@H](O)[C@H]1O
Value:=4360nM
Source:
Assay:Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis
Type:Kd
SMILES:CNc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COCc2cccnc2)[C@@H](O)[C@H]1O
Value:=2710nM
Source:
Assay:Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis
Type:Kd
SMILES:CNc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COCC(N)=O)[C@@H](O)[C@H]1O
Value:=12360nM
Source:
Assay:Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis
Type:Kd
SMILES:Nc1ncnc2c1nc(NCc1ccc(Cl)c(Cl)c1)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Value:=990nM
Source:
Assay:Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis
Type:Kd
SMILES:Nc1ncnc2c1nc(NCc1ccc3ncccc3c1)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Value:=230nM
Source:
Assay:Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis
Type:Kd
SMILES:Nc1ncnc2c1nc(NCc1ccc3ccccc3n1)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Value:=2410nM
Source:
Assay:Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis
Type:Kd
SMILES:COC[C@H]1O[C@@H](n2c(NCc3ccc(Cl)c(Cl)c3)nc3c(N)ncnc32)[C@H](O)[C@@H]1O
Value:=250nM
Source:
Assay:Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis
Type:Kd
SMILES:Nc1ncnc2c1nc(NCc1ccc(Cl)c(Cl)c1)n2[C@@H]1O[C@H](COCc2ccccc2)[C@@H](O)[C@H]1O
Value:=770nM
Source:
Assay:Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis
Type:Kd
SMILES:N#Cc1ccc(COC[C@H]2O[C@@H](n3c(NCc4ccc(Cl)c(Cl)c4)nc4c(N)ncnc43)[C@H](O)[C@@H]2O)cc1
Value:=80nM
Source:
Assay:Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis
Type:Kd
SMILES:N#Cc1ccc(COC[C@H]2O[C@@H](n3c(NCc4ccc5ncccc5c4)nc4c(N)ncnc43)[C@H](O)[C@@H]2O)cc1
Value:=60nM
Source:
Assay:Binding affinity to Grp78 by isothermal titration calorimetric analysis
Type:Kd
SMILES:Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O
Value:=3830nM
Source:
Assay:Binding affinity to Grp78 by isothermal titration calorimetric analysis
Type:Kd
SMILES:Nc1ncnc2c1nc(N)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Value:=14140nM
Source:
Assay:Binding affinity to Grp78 by isothermal titration calorimetric analysis
Type:Kd
SMILES:Nc1ncnc2c1nc(NCc1ccc(Cl)c(Cl)c1)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Value:=870nM
Source:
Assay:Binding affinity to Grp78 by isothermal titration calorimetric analysis
Type:Kd
SMILES:Nc1ncnc2c1nc(NCc1ccc3ncccc3c1)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Value:=350nM
Source:
Assay:Binding affinity to Grp78 by isothermal titration calorimetric analysis
Type:Kd
SMILES:N#Cc1ccc(COC[C@H]2O[C@@H](n3c(NCc4ccc(Cl)c(Cl)c4)nc4c(N)ncnc43)[C@H](O)[C@@H]2O)cc1
Value:=200nM
Source:
Assay:Binding affinity to Grp78 by isothermal titration calorimetric analysis
Type:Kd
SMILES:N#Cc1ccc(COC[C@H]2O[C@@H](n3c(NCc4ccc5ncccc5c4)nc4c(N)ncnc43)[C@H](O)[C@@H]2O)cc1
Value:=100nM
Source:

Note: If you'd like to learn how our AI-powered BDE-Chem can help design therapeutic molecules against the HSPA5 target, that break through the existing patents, at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai

Molecules for More Common Targets

ABCB1 | ABCG2 | ACE2 | AHR | AKT1 | ALK | AR | ATM | BAX | BCL2 | BCL2L1 | BRAF | BRCA1 | CASP3 | CASP9 | CCL5 | CCND1 | CD274 | CD4 | CDKN1A | CXCL8 | CXCR4 | DNMT1 | EGF | EGFR | EP300 | ERBB2 | ESR1 | EZH2 | FN1 | FOXO3 | HDAC9 | HGF | HMGB1 | HSP90AA1 | HSPA5 | IDO1 | IGF1 | IGF1R | IL17A | IL6 | INS | JUN | KRAS | MAPK1 | MAPK14 | MAPK3 | MAPK8 | MAPT | MCL1 | MMP9 | MTOR | MYC | NFE2L2 | NLRP3 | NOTCH1 | PARP1 | PCNA | PDCD1 | PLK1 | PRKAA1 | PRKAA2 | PTEN | PTGS2 | PTK2 | RELA | SIRT1 | SRC | STAT1 | STAT3 | STAT5A | TERT | TLR4 | TNF | TP53 | TXN | VEGFA | YAP1