Other Name(s): Fibronectin, FN
Assay:Binding affinity to fibronectin using surface plasmon resonance imaging sensor method
Type:Kd
SMILES:CO[C@@H]1[C@@H](COS(=O)(=O)[O-])O[C@H](O[C@H]2[C@H](O)[C@@H](OS(=O)(=O)[O-])[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNc3cccc(NC(=O)CCCCC4CCSS4)c3)O[C@H]2C(=O)[O-])[C@H](NS(=O)(=O)[O-])[C@H]1O.[Na+].[Na+].[Na+].[Na+]
Value:=5.5nM
Source:
Assay:Binding affinity to fibronectin using surface plasmon resonance imaging sensor method
Type:Kd
SMILES:CO[C@@H]1[C@@H](CO)O[C@H](O[C@H]2[C@H](O)[C@@H](OS(=O)(=O)[O-])[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNc3cccc(NC(=O)CCCCC4CCSS4)c3)O[C@H]2C(=O)[O-])[C@H](NS(=O)(=O)[O-])[C@H]1O.[Na+].[Na+].[Na+]
Value:=30nM
Source:
Assay:Binding affinity to fibronectin using surface plasmon resonance imaging sensor method
Type:Kd
SMILES:CO[C@@H]1[C@@H](COS(=O)(=O)[O-])O[C@H](O[C@@H]2[C@@H](C(=O)[O-])O[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNc3cccc(NC(=O)CCCCC4CCSS4)c3)[C@H](O)[C@H]2O)[C@H](NS(=O)(=O)[O-])[C@H]1O.[Na+].[Na+].[Na+]
Value:=6.5nM
Source:
Assay:Binding affinity to fibronectin using surface plasmon resonance imaging sensor method
Type:Kd
SMILES:CO[C@@H]1[C@@H](COS(=O)(=O)[O-])O[C@H](O[C@@H]2[C@@H](C(=O)[O-])O[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNc3cccc(NC(=O)CCCCC4CCSS4)c3)[C@H](O)[C@H]2O)[C@H](N)[C@H]1O.[Na+].[Na+]
Value:=33nM
Source:
Assay:Binding interaction of the compound towards Fibronectin was determined at 25 degree C
Type:Kd
SMILES:[H]OC(CO[C@@H]1OC([C@H](O[C@@H]2OC(COS([O-])(=O)=O)[C@H](OC)C(O)[C@H]2NS([O-])(=O)=O)C(O)[C@H]1OS([O-])(=O)=O)C([O-])=O)[C@@H](O)[C@H](O)C(O)CNC3=CC(NC(=O)CCCCC4CCSS4)=CC=C3
Value:=5.5nM
Source:
Assay:Binding interaction of the compound towards Fibronectin was determined at 25 degree C
Type:Kd
SMILES:[H]OCC1O[C@@H](O[C@@H]2C(O)[C@@H](OS([O-])(=O)=O)[C@H](OCC(O[H])[C@@H](O)[C@H](O)C(O)CNC3=CC(NC(=O)CCCCC4CCSS4)=CC=C3)OC2C([O-])=O)[C@H](NS([O-])(=O)=O)C(O)[C@H]1OC
Value:=30nM
Source:
Assay:Binding interaction of the compound towards Fibronectin was determined at 25 degree C
Type:Kd
SMILES:[H]OC(CO[C@@H]1OC([C@H](O[C@@H]2OC(COS([O-])(=O)=O)[C@H](OC)C(O)[C@H]2NS([O-])(=O)=O)C(O)[C@H]1O)C([O-])=O)[C@@H](O)[C@H](O)C(O)CNC3=CC(NC(=O)CCCCC4CCSS4)=CC=C3
Value:=6.5nM
Source:
Assay:Binding interaction of the compound towards Fibronectin was determined at 25 degree C
Type:Kd
SMILES:[H]OC(CO[C@@H]1OC([C@H](O[C@@H]2OC(CO)[C@H](OC)C(O)[C@H]2NS([O-])(=O)=O)C(O)[C@H]1O)C([O-])=O)[C@@H](O)[C@H](O)C(O)CNC3=CC(NC(=O)CCCCC4CCSS4)=CC=C3
Value:=33nM
Source:
Assay:Dissociation constant of compound towards Mycobacterium avium paratuberculosis antigen 85 binding to human plasma fibronectin (0.5 ug) upon incubation in 0.1 M NaHCO3, pH 9.3 at 37 degree C for 1 h by ELISA
Type:Kd
SMILES:CC(C)C[C@H](NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Value:=414.2nM
Source:Human
Assay:Inhibitory concentration for very late antigen-4-mediated binding of SKW3 cells to fibronectin
Type:IC50
SMILES:CN1C(=O)N(C(=O)[C@@]1(C)CC2=CC=C(Br)C=C2)C3=CC(Cl)=CC(Cl)=C3
Value:>250uM
Source:
Assay:Inhibitory concentration of the compound against jurkat cells binding to fibronectin via integrin alpha5 beta1 receptor
Type:IC50
SMILES:CCCCOC(=O)N1C[C@]2(CC1CNC1=NC3=CC=CC=C3N1)CC(=NO2)C(=O)NC[C@H](NS(=O)(=O)C1=C(C)C=C(C)C=C1C)C(O)=O
Value:=0.25uM
Source:

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