Other Name(s): Caspase 9, Caspase, Caspase-9
Assay:Binding affinity towards human Caspase-9
Type:IC50
SMILES:CC(C)C[C@H](NC(=O)CNc1cccc2ccccc12)C(=O)N[C@H](C=O)CC(=O)O
Value:=160nM
Source:
Assay:Binding affinity towards human Caspase-9
Type:IC50
SMILES:CC(C)C[C@H](NC(=O)C(=O)Nc1cccc2ccccc12)C(=O)N[C@H](C=O)CC(=O)O
Value:=230nM
Source:
Assay:Binding affinity towards human Caspase-9
Type:IC50
SMILES:CC(C)C[C@H](NC(=O)COc1cccc2ccccc12)C(=O)N[C@H](C=O)CC(=O)O
Value:=2720nM
Source:
Assay:Compound was evaluated for its inhibitory activity against the Caspase-9 enzyme
Type:IC50
SMILES:CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)NC(CC(=O)O)C(=O)CF
Value:=5nM
Source:
Assay:Inhibitory activity against Caspase-9
Type:Ki
SMILES:CN1C(=O)C(=O)c2cc([N+](=O)[O-])ccc21
Value:=7200nM
Source:
Assay:Inhibitory activity against Caspase-9
Type:Ki
SMILES:O=C1C(=O)N(Cc2ccccc2)c2ccc([N+](=O)[O-])cc21
Value:=5000nM
Source:
Assay:Inhibitory activity against Caspase-9
Type:Ki
SMILES:O=C1Nc2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc2C1=O
Value:=1200nM
Source:
Assay:Inhibitory activity against Caspase-9
Type:Ki
SMILES:CN(CC1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2)c1ccccc1
Value:>50000nM
Source:
Assay:Inhibitory activity against Caspase-9
Type:Ki
SMILES:O=C1Nc2ccc(S(=O)(=O)N3CCC[C@H]3CNc3ccccc3)cc2C1=O
Value:=850nM
Source:
Assay:Inhibitory activity against Caspase-9
Type:Ki
SMILES:O=C1C(=O)N(Cc2ccccc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21
Value:=120nM
Source:
Assay:Inhibitory activity against Caspase-9
Type:Ki
SMILES:COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2
Value:=1100nM
Source:
Assay:Inhibitory activity against Caspase-9
Type:Ki
SMILES:O=C1Nc2ccc(S(=O)(=O)N3CCCC3)cc2C1=O
Value:=12000nM
Source:
Assay:Inhibitory concentration against Caspase-9
Type:IC50
SMILES:CC(C)[C@H](OC(=O)Nc1ccccc1)C(=O)NC(CC(=O)O)C(=O)CF
Value:=30nM
Source:
Assay:Inhibition concentration required against caspase-9
Type:IC50
SMILES:CC(C)[C@H](NC(=O)OCc1ccc(Cl)cc1Cl)C(=O)NC(CC(=O)O)C(=O)CF
Value:=9nM
Source:
Assay:Inhibition of human caspase 9
Type:IC50
SMILES:CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1C(=O)NC(C(=O)O)C(=O)CF
Value:=6nM
Source:Homo sapiens
Assay:Inhibition of human recombinant caspase 9 preincubated for 10 mins
Type:IC50
SMILES:CCOC(=O)COc1cc(C(=O)O)c(O)c2ccccc12
Value:=93000nM
Source:Homo sapiens
Assay:Inhibition of caspase 9 after 10 to 15 mins by fluorescence assay
Type:IC50
SMILES:COC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@H](C)NC(=O)[C@@H](NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](OC(=O)[C@@H](OC(=O)[C@H](C(C)C)N(C)C)C(C)C)C(C)C)[C@@H](C)O
Value:=5000nM
Source:
Assay:Inhibition of caspase-9 (unknown origin)
Type:IC50
SMILES:CC(C)(C)[C@@H](NC(=O)c1ccc(N)c(Cl)c1)C(=O)N1CCC[C@H]1C(=O)N[C@H](/C=C/S(C)(=O)=O)CC(=O)O
Value:=2300nM
Source:Homo sapiens
Assay:Inhibition of caspase-9 (unknown origin)
Type:IC50
SMILES:CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@H](/C=C/S(C)(=O)=O)CC(=O)O
Value:=1740nM
Source:Homo sapiens
Assay:Inhibition of caspase-9 (unknown origin)
Type:IC50
SMILES:CC(C)(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)OCc1ccccc1)C(=O)N1CC[C@H]1C(=O)N[C@H](/C=C/S(C)(=O)=O)CC(=O)O
Value:=1100nM
Source:Homo sapiens

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