Other Name(s): ERK1, ERK1/2, Extracellular Signal-regulated Kinase 1 And 2, Erk1
Assay:Inhibition of ERK1 ser/thr kinase.
Type:IC50
SMILES:O=C(Nc1ccccn1)Nc1cccc2c1[C@H]1CCCN1C2=O
Value:>10000nM
Source:Homo sapiens
Assay:Inhibition of Extracellular signal-regulated kinase 1
Type:IC50
SMILES:Nc1nccc(-c2c[nH]c3c(Br)ccc(O)c23)n1
Value:>100000nM
Source:
Assay:Inhibition of Extracellular signal-regulated kinase 1
Type:IC50
SMILES:O=C1NCc2c(-c3ccc(F)cc3F)cc(C3CCNCC3)cc2N1c1c(Cl)cccc1Cl
Value:>10000nM
Source:
Assay:Selectivity against Extracellular signal-regulated kinase 1 (Erk-1)
Type:IC50
SMILES:Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1
Value:>20000nM
Source:
Assay:Inhibition of Mitogen-activated protein kinase 3 (MAPK-ERK1)
Type:IC50
SMILES:CC(C)[C@H](CO)Nc1nc(Nc2ccc(C(=O)O)c(Cl)c2)c2ncn(C(C)C)c2n1
Value:=3300nM
Source:
Assay:Inhibition of Mitogen-activated protein kinase 3 (MAPK-ERK1)
Type:IC50
SMILES:Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc21
Value:=30000nM
Source:
Assay:Inhibition of Mitogen-activated protein kinase 3 (MAPK-ERK1)
Type:IC50
SMILES:CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1
Value:=34000nM
Source:
Assay:Inhibition of Mitogen-activated protein kinase 3 (MAPK-ERK1)
Type:IC50
SMILES:CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1
Value:=9000nM
Source:
Assay:Inhibition of Mitogen-activated protein kinase 3 (MAPK-ERK1)
Type:IC50
SMILES:CC(C)=CCNc1nc(N)nc2c1ncn2C(C)C
Value:=90000nM
Source:
Assay:Inhibition of Mitogen-activated protein kinase 3
Type:IC50
SMILES:CCCCc1c(-c2ccc(O)cc2)[nH]c2nccnc12
Value:=18000nM
Source:
Assay:Inhibition of ERK1 kinase
Type:IC50
SMILES:N#C/C(=C1/Nc2ccccc2S1)c1ccnc(NCCc2cccnc2)n1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Value:>10000nM
Source:
Assay:Inhibitory concentration against Extracellular signal-regulated kinase 1
Type:IC50
SMILES:FC(F)(F)c1cnc(Nc2ccc(Br)cc2)nc1Nc1ccc2[nH]cnc2c1
Value:=750nM
Source:Homo sapiens
Assay:Inhibitory concentration against Extracellular signal-regulated kinase 1
Type:IC50
SMILES:FC(F)(F)c1cnc(Nc2ccc3[nH]cnc3c2)nc1Nc1ccccc1Cl
Value:>1000nM
Source:Homo sapiens
Assay:Inhibitory concentration against Extracellular signal-regulated kinase 1
Type:IC50
SMILES:COc1ccc(Nc2nc(Nc3ccc4[nH]cnc4c3)ncc2C(F)(F)F)cc1
Value:>1000nM
Source:Homo sapiens
Assay:Inhibitory concentration against Extracellular signal-regulated kinase 1
Type:IC50
SMILES:N#CNc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc4[nH]cnc4c3)n2)cc1NC#N
Value:=300nM
Source:Homo sapiens
Assay:Inhibition of mitogen activated protein kinase in cell-free assay
Type:IC50
SMILES:COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC
Value:>10000nM
Source:
Assay:Inhibition of extracellular signal-regulated kinase 1 (ERK1)
Type:IC50
SMILES:O=C(Nc1ccc(Cl)c(COc2cccnc2)c1)c1cc(F)cc(N2CCOCC2)c1
Value:>10000nM
Source:
Assay:Inhibitory concentration against mitogen-activated protein kinase 3
Type:IC50
SMILES:CCc1nc(-c2cccc(C)c2)c(-c2ccnc(NC(=O)c3ccccc3)c2)s1
Value:>10000nM
Source:Homo sapiens
Assay:Inhibition of MK3
Type:Ki
SMILES:CCOc1nc(NC(C)=O)cc(N)c1C#N
Value:>9200nM
Source:
Assay:Inhibition of MK3
Type:Ki
SMILES:CCOc1nc(NC(=O)Cc2cc(OC)c(S(C)(=O)=O)cc2OC)cc(N)c1Cl
Value:>9200nM
Source:

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