Other Name(s): PLK-1, Plk1
Assay:Selective inhibition of protein kinase PIk1
Type:Ki
SMILES:Cc1nc(N)sc1-c1ccnc(Nc2cccc([N+](=O)[O-])c2)n1
Value:>1000nM
Source:
Assay:Inhibition of PLK1 kinase
Type:IC50
SMILES:O=C(Cc1ccc2ccccc2c1)Nc1cc(C2CC2)n[nH]1
Value:>10000nM
Source:
Assay:Inhibitory activity against Plk1
Type:IC50
SMILES:COC(=O)c1cc2c(C)n[nH]c2s1
Value:>100000nM
Source:Homo sapiens
Assay:Inhibitory activity against Plk1
Type:IC50
SMILES:Cc1n[nH]c2sc(C(N)=O)c(NC(=O)Nc3ccccc3)c12
Value:>20000nM
Source:Homo sapiens
Assay:Inhibitory activity against Plk1
Type:IC50
SMILES:Cc1n[nH]c2sc(C(N)=O)c(NC(=O)c3ccc(Cl)cc3)c12
Value:>100000nM
Source:Homo sapiens
Assay:Inhibitory activity against Plk1
Type:IC50
SMILES:Cc1n[nH]c2sc(C(N)=O)c(NC(=O)c3cccc(Cl)c3)c12
Value:>100000nM
Source:Homo sapiens
Assay:Inhibitory activity against Plk1
Type:IC50
SMILES:Cc1n[nH]c2sc(C(N)=O)c(NC(=O)c3ccccc3Cl)c12
Value:=23000nM
Source:Homo sapiens
Assay:Inhibitory activity against Plk1
Type:IC50
SMILES:Cc1n[nH]c2sc(C(N)=O)c(NC(=O)c3cccs3)c12
Value:>100000nM
Source:Homo sapiens
Assay:Inhibitory activity against Plk1
Type:IC50
SMILES:Cc1n[nH]c2sc(C(N)=O)c(NC(=O)COc3ccccc3)c12
Value:>100000nM
Source:Homo sapiens
Assay:Inhibitory activity against Plk1
Type:IC50
SMILES:COC(=O)C(=O)Nc1c(C(N)=O)sc2[nH]nc(C)c12
Value:=8000nM
Source:Homo sapiens
Assay:Inhibitory activity against Plk1
Type:IC50
SMILES:CC(=O)Nc1c(C(N)=O)sc2[nH]nc(C)c12
Value:>20000nM
Source:Homo sapiens
Assay:Inhibitory activity against Plk1
Type:IC50
SMILES:CN1CCN(C(=O)c2cc3c(-c4ccccc4)[nH]nc3s2)CC1
Value:>20000nM
Source:Homo sapiens
Assay:Inhibitory activity against Plk1
Type:IC50
SMILES:COc1ccc(CNC(=O)c2cc3c(-c4ccccc4)[nH]nc3s2)cc1
Value:>20000nM
Source:Homo sapiens
Assay:Inhibitory activity against Plk1
Type:IC50
SMILES:O=C(NCCc1ccccc1)c1cc2c(-c3ccccc3)[nH]nc2s1
Value:=17000nM
Source:Homo sapiens
Assay:Inhibitory activity against Plk1
Type:IC50
SMILES:O=C(NC1CCCCC1)c1cc2c(-c3ccccc3)[nH]nc2s1
Value:=12000nM
Source:Homo sapiens
Assay:Inhibitory activity against Plk1
Type:IC50
SMILES:CCCCN(C)C(=O)c1cc2c(-c3ccccc3)[nH]nc2s1
Value:>20000nM
Source:Homo sapiens
Assay:Inhibitory activity against Plk1
Type:IC50
SMILES:Cc1n[nH]c2sc(C(=O)NCc3ccccc3)cc12
Value:=16000nM
Source:Homo sapiens
Assay:Inhibitory activity against Plk1
Type:IC50
SMILES:Cc1n[nH]c2sc(C(=O)NC3CCCCC3)cc12
Value:>20000nM
Source:Homo sapiens
Assay:Inhibitory activity against Plk1
Type:IC50
SMILES:CCCCN(C)C(=O)c1cc2c(C)n[nH]c2s1
Value:>20000nM
Source:Homo sapiens
Assay:Inhibitory activity against Plk1
Type:IC50
SMILES:CCCCNC(=O)c1cc2c(C)n[nH]c2s1
Value:>20000nM
Source:Homo sapiens

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