Other Name(s): JNK1, JNK
Assay:Inhibition of JNK1 kinase
Type:IC50
SMILES:CN1CCC(O)(c2nc(-c3ccc(F)cc3)c(-c3ccncc3)o2)CC1
Value:>10000nM
Source:Homo sapiens
Assay:Inhibition of JNK1 kinase
Type:IC50
SMILES:COc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCNCC2)n1
Value:>50nM
Source:
Assay:Inhibition of JNK1 kinase
Type:IC50
SMILES:COc1nccc(-c2c(-c3ccc(F)cc3)ncn2[C@H]2CC[C@H](O)CC2)n1
Value:>50nM
Source:
Assay:Inhibition of c-Jun N-terminal kinase (Jnk)
Type:IC50
SMILES:COc1cc2ncnc(N3CCN(/C(S)=N\Cc4ccc5c(c4)OCO5)CC3)c2cc1OC
Value:>30000nM
Source:
Assay:Inhibition of c-Jun N-terminal kinase (Jnk)
Type:IC50
SMILES:COc1cc2ncnc(N3CCN(/C(S)=N\Cc4ccccc4)CC3)c2cc1OC
Value:>30000nM
Source:
Assay:Inhibition of human c-Jun N-terminal kinase 1
Type:IC50
SMILES:C[C@H](Nc1cc(-c2sc(C3CCN(C)CC3)nc2-c2ccc(F)cc2)ccn1)c1ccccc1
Value:=1900nM
Source:Homo sapiens
Assay:Inhibition of human c-Jun N-terminal kinase 1
Type:IC50
SMILES:CN1CCN(c2ccc3c(n2)nc(-c2ccc(F)cc2)n3-c2ccnc(NC3CCCC3)n2)CC1
Value:=1500nM
Source:Homo sapiens
Assay:Inhibition of human c-Jun N-terminal kinase 1
Type:IC50
SMILES:OC1(c2nc(-c3ccc(F)cc3)c(-c3ccnc(NC4CCCCC4)c3)o2)CCNCC1
Value:=150nM
Source:Homo sapiens
Assay:Inhibition of human c-Jun N-terminal kinase 1
Type:IC50
SMILES:CN1CCC(O)(c2cn(-c3ccnc(NC4CCCC4)n3)c(-c3cccc(C(F)(F)F)c3)n2)CC1
Value:>10000nM
Source:Homo sapiens
Assay:Inhibition of c-Jun N-terminal kinase 1
Type:IC50
SMILES:CC(C)(C)c1cc(NC(=O)Nc2cccc(Cl)c2Cl)n(-c2cccc(N)c2)n1
Value:=850nM
Source:
Assay:Inhibition of c-Jun N-terminal kinase 1
Type:IC50
SMILES:COc1cc2ncnc(N3CCN(C(=O)Nc4ccc([N+](=O)[O-])cc4)CC3)c2cc1OC
Value:>30000nM
Source:
Assay:Inhibition of c-Jun N-terminal kinase 1
Type:IC50
SMILES:COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Br)cc4)CC3)c2cc1OC
Value:>30000nM
Source:
Assay:Inhibition of c-Jun N-terminal kinase 1
Type:IC50
SMILES:COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(C#N)cc4)CC3)c2cc1OC
Value:>30000nM
Source:
Assay:Inhibition of c-Jun N-terminal kinase 1
Type:IC50
SMILES:C[C@H](O)CNc1cc(-c2[nH]c3cccnc3c2-c2ccc(F)cc2)ccn1
Value:>10000nM
Source:
Assay:Inhibition of c-Jun N-terminal kinase 1-alpha 1
Type:IC50
SMILES:C[S+]([O-])c1ccc(-c2cc(-c3ccncc3)c(-c3ccc(F)cc3)[nH]2)cc1
Value:=16000nM
Source:
Assay:Inhibition of c-Jun N-terminal kinase 1-beta 1
Type:IC50
SMILES:CC(C)OCc1ccc2c(c1)c1c3c(c4c(c1n2CCCO)Cc1ccccc1-4)C(=O)NC3
Value:=448nM
Source:Homo sapiens
Assay:Inhibition of c-Jun N-Terminal kinase 1
Type:IC50
SMILES:N#C/C(=C1/Nc2ccccc2S1)c1ccnc(NCCc2cccnc2)n1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Value:=150nM
Source:
Assay:Inhibition of c-Jun N-terminal kinase 1-alpha 1 binding in fluorescence polarization assay
Type:IC50
SMILES:Cc1cccc(-c2n[nH]cc2-c2ccc3ncccc3n2)n1
Value:>16000nM
Source:Homo sapiens
Assay:Negative log of inhibitory concentration determined against c-Jun N-terminal kinase (Activity reported against the isolated JNK-1 enzyme)
Type:IC50
SMILES:CC(=O)Nc1ccc(CNc2[nH]nc3cccc(Oc4ccc(S(C)(=O)=O)cc4)c23)cc1
Value:=794.33nM
Source:Homo sapiens
Assay:Negative log of inhibitory concentration determined against c-Jun N-terminal kinase (Activity reported against the isolated JNK-1 enzyme)
Type:IC50
SMILES:COc1ccc(OC)c(CNc2[nH]nc3cccc(Oc4ccc(S(C)(=O)=O)cc4)c23)c1
Value:=398.11nM
Source:Homo sapiens

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