Other Name(s): Sirtuin-1, Sirt1
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:NC(=O)C1CCCc2c1[nH]c1ccc(Cl)cc21
Value:=98nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:Cc1ccc2[nH]c3c(c2c1)CCCC3C(N)=O
Value:=205nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:NC(=O)C1CCCc2c1[nH]c1ccccc21
Value:=1470nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:NC(=O)C1CCCCc2c1[nH]c1ccc(Cl)cc21
Value:=124nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:NC(=O)C1CCCc2c1[nH]c1ccc(Cl)cc21
Value:=123nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:NC(=O)C1CCCc2c1[nH]c1ccc(Cl)cc21
Value:>100000nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:CCOC(=O)C1CCCc2c1[nH]c1ccc(Cl)cc21
Value:>100000nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:O=C(O)C1CCCc2c1[nH]c1ccc(Cl)cc21
Value:>100000nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:NC(=O)C1CCCc2c1[nH]c1ccc(O)cc21
Value:=15000nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:O=C(NO)C1CCCc2c1[nH]c1ccc(Cl)cc21
Value:=77600nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:NC(=O)C1CCc2c([nH]c3ccc(Cl)cc23)C1
Value:=34500nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:NC(=O)C1CCc2c([nH]c3ccc(Br)cc23)C1
Value:=2440nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:CCNC(=O)C1CCCc2c1[nH]c1ccc(Cl)cc21
Value:>100000nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:CCN(CC)C(=O)C1CCCc2c1[nH]c1ccc(Cl)cc21
Value:>100000nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:NC(=O)CNC(=O)C1CCCc2c1[nH]c1ccc(Cl)cc21
Value:>100000nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:Cc1ccc2[nH]c3c(c2c1)CCCC3CN
Value:>100000nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:Cc1ccc2c(c1)c1c(n2C)C(C(N)=O)CCC1
Value:>100000nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:Cc1ccc2[nH]c3c(c2c1)CCCC3(C)C(N)=O
Value:=13000nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:NC(=O)C1CCCC2c3cc(Cl)ccc3NC12
Value:>100000nM
Source:Homo sapiens
Assay:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay
Type:IC50
SMILES:NC(=O)C1NCCc2c1[nH]c1ccc(Cl)cc21
Value:=18000nM
Source:Homo sapiens

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