Other Name(s): Mcl-1, MCL-1
Assay:Binding affinity to Mcl1
Type:Kd
SMILES:CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCC(C)(C)CC3)cc2)cc1[N+](=O)[O-]
Value:>10000nM
Source:Homo sapiens
Assay:Displacement of FAM-Bid from human Mcl1 by FP assay
Type:Ki
SMILES:Cc1cc2c(C(C)C)c(O)c(O)c(C=O)c2c(O)c1-c1c(C)cc2c(C(C)C)c(O)c(O)c(C=O)c2c1O
Value:=180nM
Source:Homo sapiens
Assay:Displacement of FAM-Bid from human Mcl1 by FP assay
Type:Ki
SMILES:CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C
Value:=12nM
Source:Homo sapiens
Assay:Displacement of FAM-Bid from human Mcl1 by FP assay
Type:Ki
SMILES:CC(C)c1ccccc1Cc1cc(C(=O)Nc2ccc(S(=O)(=O)c3ccccc3C(C)(C)C)cc2)c(O)c(O)c1O
Value:=260nM
Source:Homo sapiens
Assay:Displacement of FAM-Bid from human Mcl1 by FP assay
Type:IC50
SMILES:CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C
Value:=52nM
Source:Homo sapiens
Assay:Displacement of FAM-Bid from human Mcl1 by FP assay
Type:IC50
SMILES:CC(C)c1ccccc1Cc1cc(C(=O)Nc2ccc(S(=O)(=O)c3ccccc3C(C)(C)C)cc2)c(O)c(O)c1O
Value:=1030nM
Source:Homo sapiens
Assay:Displacement of FAM-Bid BH3 peptide from human Mcl1 by FP-based binding assay
Type:Ki
SMILES:CN(CCCc1ccccc1)S(=O)(=O)c1cc(C(=O)N2CCc3ccc(S(=O)(=O)NCCc4ccccc4)cc3C2)c(O)c(O)c1O
Value:=150nM
Source:Homo sapiens
Assay:Displacement of biotinylated Bim BH3 peptide from recombinant His-tagged Mcl1 by ELISA assay
Type:IC50
SMILES:CN(CCCc1ccccc1)S(=O)(=O)c1cc(C(=O)N2CCc3ccc(S(=O)(=O)NCCc4ccccc4)cc3C2)c(O)c(O)c1O
Value:=39nM
Source:Homo sapiens
Assay:Displacement of FAM-Bim peptide from human Mcl1 by fluorescence polarization assay
Type:Ki
SMILES:Cc1oc2c(CC(C)C)c(O)c(O)c(O)c2c(=O)c1-c1ccccc1
Value:=400nM
Source:Homo sapiens
Assay:Displacement of FAM-Bim peptide from human Mcl1 by fluorescence polarization assay
Type:Ki
SMILES:Cc1cc2c(C(C)C)c(O)c(O)c(C=O)c2c(O)c1-c1c(C)cc2c(C(C)C)c(O)c(O)c(C=O)c2c1O
Value:=280nM
Source:Homo sapiens
Assay:Displacement of FAM-Bim peptide from human Mcl1 by fluorescence polarization assay
Type:Ki
SMILES:Cc1oc2c(CC(C)C)c(O)c(O)c(O)c2c(=O)c1-c1ccc(-c2c(C)oc3c(CC(C)C)c(O)c(O)c(O)c3c2=O)cc1
Value:=18nM
Source:Homo sapiens
Assay:Displacement of FAM-Bim peptide from human Mcl1 by fluorescence polarization assay
Type:Ki
SMILES:Cc1cc(=O)c2c(O)c(O)c(O)c(CC(C)C)c2o1
Value:=1690nM
Source:Homo sapiens
Assay:Inhibition of human Mcl-1 protein by fluorescence polarization assay
Type:IC50
SMILES:CC(C)c1cc(C(=O)c2ccccc2)c(O)c(O)c1O
Value:=36490nM
Source:Homo sapiens
Assay:Inhibition of human Mcl-1 protein by fluorescence polarization assay
Type:Ki
SMILES:CC(C)c1cc(C(=O)c2ccccc2)c(O)c(O)c1O
Value:=4600nM
Source:Homo sapiens
Assay:Inhibition of human Mcl-1 protein by fluorescence polarization assay
Type:IC50
SMILES:O=C(c1ccc(Oc2ccccc2)cc1)c1cc(C(=O)c2nc3ccccc3s2)c(O)c(O)c1O
Value:=310nM
Source:Homo sapiens
Assay:Inhibition of human Mcl-1 protein by fluorescence polarization assay
Type:Ki
SMILES:O=C(c1ccc(Oc2ccccc2)cc1)c1cc(C(=O)c2nc3ccccc3s2)c(O)c(O)c1O
Value:=37nM
Source:Homo sapiens
Assay:Inhibition of human Mcl-1 protein by fluorescence polarization assay
Type:IC50
SMILES:O=C(c1ccc(Oc2ccccc2)cc1)c1cc(C(=O)c2cccc3ccccc23)c(O)c(O)c1O
Value:=1200nM
Source:Homo sapiens
Assay:Inhibition of human Mcl-1 protein by fluorescence polarization assay
Type:Ki
SMILES:O=C(c1ccc(Oc2ccccc2)cc1)c1cc(C(=O)c2cccc3ccccc23)c(O)c(O)c1O
Value:=150nM
Source:Homo sapiens
Assay:Inhibition of human Mcl-1 protein by fluorescence polarization assay
Type:IC50
SMILES:CC(C)C(=O)c1cc(C(=O)c2ccc(Oc3ccccc3)cc2)c(O)c(O)c1O
Value:=2670nM
Source:Homo sapiens
Assay:Inhibition of human Mcl-1 protein by fluorescence polarization assay
Type:Ki
SMILES:CC(C)C(=O)c1cc(C(=O)c2ccc(Oc3ccccc3)cc2)c(O)c(O)c1O
Value:=340nM
Source:Homo sapiens

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