 | | Assay: | Binding affinity to His-tagged PD-L1 (unknown origin) assessed as inhibition of interaction with PD1 preincubated for 15 mins followed by PD1 addition measured after 15 mins by HTRF assay | | Type: | IC50 | | SMILES: | COc1cc(OCc2cccc(-c3ccccc3)c2C)cc(OC)c1CNC(CO)(CO)CO | | Value: | =6nM | | Source: | Homo sapiens |
|
 | | Assay: | Binding affinity to His-tagged PD-L1 (unknown origin) assessed as inhibition of interaction with PD1 preincubated for 15 mins followed by PD1 addition measured after 15 mins by HTRF assay | | Type: | IC50 | | SMILES: | COc1cc(OCc2cccc(-c3ccccc3)c2C#N)cc(OC)c1CN1CCCC[C@H]1C(=O)O | | Value: | =6nM | | Source: | Homo sapiens |
|
 | | Assay: | Binding affinity to His-tagged PD-L1 (unknown origin) assessed as inhibition of interaction with PD1 preincubated for 15 mins followed by PD1 addition measured after 15 mins by HTRF assay | | Type: | IC50 | | SMILES: | Cc1c(COc2ccc(CNCC3CCC(=O)N3)cc2)cccc1-c1ccccc1 | | Value: | =1010nM | | Source: | Homo sapiens |
|
 | | Assay: | Binding affinity to His-tagged PD-L1 (unknown origin) assessed as inhibition of interaction with PD1 preincubated for 15 mins followed by PD1 addition measured after 15 mins by HTRF assay | | Type: | IC50 | | SMILES: | Cc1c(COc2ccc(CN[C@H](C)C(=O)O)cc2Cl)cccc1-c1ccccc1 | | Value: | =6nM | | Source: | Homo sapiens |
|
 | | Assay: | Binding affinity to His-tagged PD-L1 (unknown origin) assessed as inhibition of interaction with PD1 preincubated for 15 mins followed by PD1 addition measured after 15 mins by HTRF assay | | Type: | IC50 | | SMILES: | Cc1cc(CN2CCC(C(=O)NCCO)CC2)ccc1OCc1cccc(-c2ccccc2)c1C | | Value: | =110nM | | Source: | Homo sapiens |
|
 | | Assay: | Binding affinity to His-tagged PD-L1 (unknown origin) assessed as inhibition of interaction with PD1 preincubated for 15 mins followed by PD1 addition measured after 15 mins by HTRF assay | | Type: | IC50 | | SMILES: | COc1cc(OCc2cccc(-c3ccccc3)c2C)cc(OC)c1CN1CCCC[C@H]1C(=O)O | | Value: | =6nM | | Source: | Homo sapiens |
|
 | | Assay: | Binding affinity to 15N-labeled human PD-L1 (18 to 134 residues) expressed in Escherichia coli BL21(DE3) by 1H-15N 2D HMQC NMR spectroscopic analysis | | Type: | Kd | | SMILES: | COc1cc(OCc2cccc(-c3ccccc3)c2C)cc(OC)c1CNCCNC(C)=O | | Value: | <1000nM | | Source: | Homo sapiens |
|
 | | Assay: | Binding affinity to 15N-labeled human PD-L1 (18 to 134 residues) expressed in Escherichia coli BL21(DE3) by 1H-15N 2D HMQC NMR spectroscopic analysis | | Type: | Kd | | SMILES: | Cc1c(COc2cc(F)c(CNC[C@@H](O)CC(=O)O)cc2F)cccc1-c1ccc2c(c1)OCCO2 | | Value: | <1000nM | | Source: | Homo sapiens |
|
 | | Assay: | Binding affinity to His-tagged PD-L1 (unknown origin) assessed as reduction in PD-L1/PD1-Ig interaction preincubated with PD-L1 for 15 mins followed by addition of PD1-Ig measured after 15 mins by HTRF assay | | Type: | IC50 | | SMILES: | COc1cc(OCc2cccc(-c3ccccc3)c2C)cc(OC)c1CNCCNC(C)=O | | Value: | =6nM | | Source: | Homo sapiens |
|
 | | Assay: | Binding affinity to His-tagged PD-L1 (unknown origin) assessed as reduction in PD-L1/PD1-Ig interaction preincubated with PD-L1 for 15 mins followed by addition of PD1-Ig measured after 15 mins by HTRF assay | | Type: | IC50 | | SMILES: | Cc1c(COc2ccc(CN3CCCCC3C(=O)O)cc2Br)cccc1-c1ccccc1 | | Value: | =146nM | | Source: | Homo sapiens |
|
 | | Assay: | Binding affinity to His-tagged PD-L1 (unknown origin) assessed as reduction in PD-L1/PD1-Ig interaction preincubated with PD-L1 for 15 mins followed by addition of PD1-Ig measured after 15 mins by HTRF assay | | Type: | IC50 | | SMILES: | COc1nc(OCc2cccc(-c3ccccc3)c2C)ccc1CNCCNC(C)=O | | Value: | =18nM | | Source: | Homo sapiens |
|
 | | Assay: | Binding affinity to His-tagged PD-L1 (unknown origin) assessed as reduction in PD-L1/PD1-Ig interaction preincubated with PD-L1 for 15 mins followed by addition of PD1-Ig measured after 15 mins by HTRF assay | | Type: | IC50 | | SMILES: | COc1cc(OCc2cccc(-c3ccccc3)c2C)cc(OC)c1CN[C@@H](CO)C(C)C | | Value: | =6nM | | Source: | Homo sapiens |
|
 | | Assay: | Binding affinity to His-tagged PD-L1 (unknown origin) assessed as reduction in PD-L1/PD1-Ig interaction preincubated with PD-L1 for 15 mins followed by addition of PD1-Ig measured after 15 mins by HTRF assay | | Type: | IC50 | | SMILES: | Cc1c(COc2cc(F)c(CNC[C@@H](O)CC(=O)O)cc2F)cccc1-c1ccc2c(c1)OCCO2 | | Value: | =80nM | | Source: | Homo sapiens |
|
 | | Assay: | Binding affinity to His-tagged PD-L1 (unknown origin) assessed as reduction in PD-L1/PD1-Ig interaction preincubated with PD-L1 for 15 mins followed by addition of PD1-Ig measured after 15 mins by HTRF assay | | Type: | IC50 | | SMILES: | Cc1cc(CN[C@H](CO)C(=O)O)c(OCc2cccc(C#N)c2)cc1OCc1cccc(-c2ccc3c(c2)OCCO3)c1C | | Value: | =2.25nM | | Source: | Homo sapiens |
|
 | | Assay: | Binding affinity to His-tagged PD-L1 (unknown origin) assessed as reduction in PD-L1/PD1-Ig interaction preincubated with PD-L1 for 15 mins followed by addition of PD1-Ig measured after 15 mins by HTRF assay | | Type: | IC50 | | SMILES: | Cc1c(COc2cc(OCc3cccc(C#N)c3)c(CN3C[C@H](O)C[C@@H]3C(=O)O)cc2Cl)cccc1-c1ccc2c(c1)OCCO2 | | Value: | =1.4nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of PD-L1 (unknown origin) | | Type: | IC50 | | SMILES: | COc1nc(OCc2cccc(-c3ccccc3)c2C)ccc1CNCCNC(C)=O | | Value: | =18nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of PD-L1 (unknown origin) | | Type: | IC50 | | SMILES: | Cc1c(COc2ccc(CN3CCCCC3C(=O)O)cc2Br)cccc1-c1ccccc1 | | Value: | =146nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of PD-L1 (unknown origin) | | Type: | IC50 | | SMILES: | Cc1c(COc2cc(F)c(CNC[C@@H](O)CC(=O)O)cc2F)cccc1-c1ccc2c(c1)OCCO2 | | Value: | =80nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of PD-L1 (unknown origin) | | Type: | IC50 | | SMILES: | CCCC[C@H]1C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NC(C(=O)NCC(N)=O)CSCC(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N2CCCC2C(=O)N[C@@H](CC(C)C)C(=O)NC(=O)N(C)CC(=O)NCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1C | | Value: | =5.2nM | | Source: | Homo sapiens |
|
 | | Assay: | Binding affinity to Fc-labeled human PDL1 expressed in Escherichia coli by SPR spectroscopy | | Type: | Kd | | SMILES: | C[C@@H](O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | | Value: | =510nM | | Source: | Homo sapiens |
|
