Other Name(s): DNMT
Assay:Inhibitory activity against DNA methyl transferase in leukemic NALM6 cells
Type:IC50
SMILES:Cc1ccn2c(CCc3nnc4cc(C)ccn34)nnc2c1
Value:=100000nM
Source:Homo sapiens
Assay:Inhibitory activity against DNA methyl transferase in leukemic NALM6 cells
Type:IC50
SMILES:O=C(O)C(Cc1c[nH]c2ccccc12)N1C(=O)c2ccccc2C1=O
Value:=50000nM
Source:Homo sapiens
Assay:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells
Type:IC50
SMILES:Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O
Value:=2000nM
Source:Homo sapiens
Assay:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells
Type:IC50
SMILES:N[C@@H](CCSC[C@H]1O[C@@H](n2cnc3cncnc32)[C@H](O)[C@@H]1O)C(=O)O
Value:=300000nM
Source:Homo sapiens
Assay:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells
Type:IC50
SMILES:N[C@@H](CCSC[C@H]1O[C@@H](n2cnc3c(=O)[nH]cnc32)[C@H](O)[C@@H]1O)C(=O)O
Value:>1000000nM
Source:Homo sapiens
Assay:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells
Type:IC50
SMILES:Nc1nccc2c1ncn2[C@@H]1O[C@H](CSCCC(N)C(=O)O)[C@@H](O)[C@H]1O
Value:=45000nM
Source:Homo sapiens
Assay:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells
Type:IC50
SMILES:Nc1ncnc2c1ccn2[C@@H]1O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O
Value:=1500nM
Source:Homo sapiens
Assay:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells
Type:IC50
SMILES:Nc1ncnc2c1nnn2[C@@H]1O[C@H](CSCCC(N)C(=O)O)[C@@H](O)[C@H]1O
Value:=8000nM
Source:Homo sapiens
Assay:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells
Type:IC50
SMILES:Nc1ccnc2c1ncn2[C@@H]1O[C@H](CSCCC(N)C(=O)O)[C@@H](O)[C@H]1O
Value:=45000nM
Source:Homo sapiens
Assay:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells
Type:IC50
SMILES:Nc1nc(F)nc2c1ncn2[C@@H]1O[C@H](CSCCC(N)C(=O)O)[C@@H](O)[C@H]1O
Value:=2500nM
Source:Homo sapiens
Assay:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells
Type:IC50
SMILES:Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](CSCCC(N)C(=O)O)[C@@H](O)[C@H]1O
Value:=2900nM
Source:Homo sapiens
Assay:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells
Type:IC50
SMILES:Nc1nc(I)nc2c1ncn2[C@@H]1O[C@H](CSCCC(N)C(=O)O)[C@@H](O)[C@H]1O
Value:=21000nM
Source:Homo sapiens
Assay:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells
Type:IC50
SMILES:Cc1nc(N)c2ncn([C@@H]3O[C@H](CSCCC(N)C(=O)O)[C@@H](O)[C@H]3O)c2n1
Value:=6000nM
Source:Homo sapiens
Assay:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells
Type:IC50
SMILES:COc1nc(N)c2ncn([C@@H]3O[C@H](CSCCC(N)C(=O)O)[C@@H](O)[C@H]3O)c2n1
Value:=75000nM
Source:Homo sapiens
Assay:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells
Type:IC50
SMILES:CSc1nc(N)c2ncn([C@@H]3O[C@H](CSCCC(N)C(=O)O)[C@@H](O)[C@H]3O)c2n1
Value:=216000nM
Source:Homo sapiens
Assay:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells
Type:IC50
SMILES:NC(CCSC[C@H]1O[C@@H](n2cnc3c(Nc4ccccc4)ncnc32)[C@H](O)[C@@H]1O)C(=O)O
Value:=154000nM
Source:Homo sapiens
Assay:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells
Type:IC50
SMILES:NC(CCSC[C@H]1O[C@@H](n2cnc3c(NCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O)C(=O)O
Value:=61000nM
Source:Homo sapiens
Assay:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells
Type:IC50
SMILES:NC(CCSC[C@H]1O[C@@H](n2cnc3c(NCCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O)C(=O)O
Value:=27000nM
Source:Homo sapiens
Assay:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells
Type:IC50
SMILES:NC(CCSC[C@H]1O[C@@H](n2cnc3c(NCCCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O)C(=O)O
Value:=7400nM
Source:Homo sapiens
Assay:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cells
Type:IC50
SMILES:NC(CCSC[C@H]1O[C@@H](n2cnc3c(NCCc4ccc(-c5ccccc5)cc4)ncnc32)[C@H](O)[C@@H]1O)C(=O)O
Value:=5400nM
Source:Homo sapiens

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