Other Name(s): AMPK
Assay:Average Binding Constant for PRKAA1; NA=Not Active at 10 uM
Type:Kd
SMILES:CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C
Value:=52nM
Source:Homo sapiens
Assay:Average Binding Constant for PRKAA1; NA=Not Active at 10 uM
Type:Kd
SMILES:CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1
Value:=6600nM
Source:Homo sapiens
Assay:Average Binding Constant for PRKAA1; NA=Not Active at 10 uM
Type:Kd
SMILES:CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4
Value:=9nM
Source:Homo sapiens
Assay:Average Binding Constant for PRKAA1; NA=Not Active at 10 uM
Type:Kd
SMILES:COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Value:=10000nM
Source:Homo sapiens
Assay:Inhibition of PRKAA1
Type:Kd
SMILES:CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C
Value:=52nM
Source:
Assay:Binding affinity to human AMPKA1
Type:Kd
SMILES:CCS(=O)(=O)Nc1ccc2c(c1)/C(=C(/Nc1ccc(CN3CCCCC3)cc1)c1ccccc1)C(=O)N2
Value:=19nM
Source:Homo sapiens
Assay:Binding constant for AMPK-alpha1 kinase domain
Type:Kd
SMILES:Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1
Value:>10000nM
Source:Homo sapiens
Assay:Binding constant for AMPK-alpha1 kinase domain
Type:Kd
SMILES:CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc21
Value:>10000nM
Source:Homo sapiens
Assay:Binding constant for AMPK-alpha1 kinase domain
Type:Kd
SMILES:CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1
Value:=1400nM
Source:Homo sapiens
Assay:Binding constant for AMPK-alpha1 kinase domain
Type:Kd
SMILES:CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1
Value:>10000nM
Source:Homo sapiens
Assay:Binding constant for AMPK-alpha1 kinase domain
Type:Kd
SMILES:Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1
Value:>10000nM
Source:Homo sapiens
Assay:Binding constant for AMPK-alpha1 kinase domain
Type:Kd
SMILES:CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1
Value:>10000nM
Source:Homo sapiens
Assay:Binding constant for AMPK-alpha1 kinase domain
Type:Kd
SMILES:CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1
Value:=520nM
Source:Homo sapiens
Assay:Binding constant for AMPK-alpha1 kinase domain
Type:Kd
SMILES:Cn1c(Nc2ccc(C(F)(F)F)cc2)nc2cc(Oc3ccnc(-c4ncc(C(F)(F)F)[nH]4)c3)ccc21
Value:=4500nM
Source:Homo sapiens
Assay:Binding constant for AMPK-alpha1 kinase domain
Type:Kd
SMILES:C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1
Value:>10000nM
Source:Homo sapiens
Assay:Binding constant for AMPK-alpha1 kinase domain
Type:Kd
SMILES:C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12
Value:>10000nM
Source:Homo sapiens
Assay:Binding constant for AMPK-alpha1 kinase domain
Type:Kd
SMILES:COCC(=O)NC/C=C/c1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1
Value:>10000nM
Source:Homo sapiens
Assay:Binding constant for AMPK-alpha1 kinase domain
Type:Kd
SMILES:Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1
Value:>10000nM
Source:Homo sapiens
Assay:Binding constant for AMPK-alpha1 kinase domain
Type:Kd
SMILES:CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C
Value:>10000nM
Source:Homo sapiens
Assay:Binding constant for AMPK-alpha1 kinase domain
Type:Kd
SMILES:C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1
Value:>10000nM
Source:Homo sapiens

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ABCB1 | ABCG2 | ACE2 | AHR | AKT1 | ALK | AR | ATM | BAX | BCL2 | BCL2L1 | BRAF | BRCA1 | CASP3 | CASP9 | CCL5 | CCND1 | CD274 | CD4 | CDKN1A | CXCL8 | CXCR4 | DNMT1 | EGF | EGFR | EP300 | ERBB2 | ESR1 | EZH2 | FN1 | FOXO3 | HDAC9 | HGF | HMGB1 | HSP90AA1 | HSPA5 | IDO1 | IGF1 | IGF1R | IL17A | IL6 | INS | JUN | KRAS | MAPK1 | MAPK14 | MAPK3 | MAPK8 | MAPT | MCL1 | MMP9 | MTOR | MYC | NFE2L2 | NLRP3 | NOTCH1 | PARP1 | PCNA | PDCD1 | PLK1 | PRKAA1 | PRKAA2 | PTEN | PTGS2 | PTK2 | RELA | SIRT1 | SRC | STAT1 | STAT3 | STAT5A | TERT | TLR4 | TNF | TP53 | TXN | VEGFA | YAP1