Other Name(s): Estrogen Receptor, Estrogen Receptor, ER
Assay:Transcriptional agonist activity in Chinese hamster ovary cells expressing human Estrogen Receptor alpha
Type:EC50
SMILES:Oc1ccc(-c2cc(-c3ccc(O)cc3)cc(-c3ccc(O)cc3)c2)cc1
Value:=80nM
Source:Homo sapiens
Assay:Transcriptional agonist activity in Chinese hamster ovary cells expressing human Estrogen Receptor alpha
Type:EC50
SMILES:COc1ccc(-c2cccc(-c3ccc(OC)cc3)c2)cc1
Value:>10000nM
Source:Homo sapiens
Assay:Transcriptional agonist activity in Chinese hamster ovary cells expressing human Estrogen Receptor alpha
Type:EC50
SMILES:Oc1ccc(-c2cccc(-c3ccc(O)cc3)c2)cc1
Value:=800nM
Source:Homo sapiens
Assay:Transcriptional agonist activity in Chinese hamster ovary cells expressing human Estrogen Receptor alpha
Type:EC50
SMILES:Oc1ccc(-c2ccc(-c3ccc(O)cc3)cc2)cc1
Value:=1200nM
Source:Homo sapiens
Assay:Transcriptional agonist activity in Chinese hamster ovary cells expressing human Estrogen Receptor alpha
Type:EC50
SMILES:CC1C(=O)c2cc(O)ccc2OC1c1ccc(O)cc1
Value:=4nM
Source:Homo sapiens
Assay:Transcriptional agonist activity in Chinese hamster ovary cells expressing human Estrogen Receptor alpha
Type:EC50
SMILES:COc1ccc(C2Oc3ccc(O)cc3C(=O)C2C)cc1
Value:>10000nM
Source:Homo sapiens
Assay:Effective dose in ERalpha-MCF-7 cells
Type:ED50
SMILES:O=c1c2oc3ccc(O)cc3c2oc2cc(O)cc(O)c12
Value:>500nM
Source:Homo sapiens
Assay:Antiestrogenic activity in MCF-7-2a cells as concentration required to reduce estradiol effect by 50%
Type:IC50
SMILES:Oc1ccc(C(=C(CC(F)(F)F)c2ccccc2)c2ccc(O)cc2)cc1
Value:=9nM
Source:Homo sapiens
Assay:Antiestrogenic activity in MCF-7-2a cells as concentration required to reduce estradiol effect by 50%
Type:IC50
SMILES:Oc1ccc(C(=Cc2ccccc2)c2ccc(O)cc2)cc1
Value:=150nM
Source:Homo sapiens
Assay:Antiestrogenic activity in MCF-7-2a cells as concentration required to reduce estradiol effect by 50%
Type:IC50
SMILES:CC/C(=C(\c1ccccc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
Value:=500nM
Source:Homo sapiens
Assay:Antiestrogenic activity in MCF-7-2a cells as concentration required to reduce estradiol effect by 50%
Type:IC50
SMILES:CCC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1ccccc1
Value:=15nM
Source:Homo sapiens
Assay:Antiestrogenic activity in MCF-7-2a cells as concentration required to reduce estradiol effect by 50%
Type:IC50
SMILES:CCCCC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1ccccc1
Value:=500nM
Source:Homo sapiens
Assay:Antiestrogenic activity in MCF-7-2a cells as concentration required to reduce estradiol effect by 50%
Type:IC50
SMILES:CC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1ccccc1
Value:=30nM
Source:Homo sapiens
Assay:Antiestrogenic activity in MCF-7-2a cells as concentration required to reduce estradiol effect by 50%
Type:IC50
SMILES:CCCC(=C(c1ccc(O)cc1)c1ccc(O)cc1)c1ccccc1
Value:=50nM
Source:Homo sapiens
Assay:Antiestrogenic activity in MCF-7-2a cells as concentration required to reduce estradiol effect by 50%
Type:IC50
SMILES:CC/C(=C(\c1ccccc1)c1ccc(O)cc1)c1ccccc1
Value:=7nM
Source:Homo sapiens
Assay:Affinity for human estrogen receptor alpha
Type:EC50
SMILES:NS(=O)(=O)Oc1ccc2nc(C=C3C4CC5CC(C4)CC3C5)oc2c1
Value:>100000nM
Source:Homo sapiens
Assay:Affinity for human estrogen receptor alpha
Type:EC50
SMILES:C[C@]12CC[C@@H]3c4ccc(OS(N)(=O)=O)cc4CC[C@H]3[C@@H]1CCC2=O
Value:=2600nM
Source:Homo sapiens
Assay:Binding affinity for Estrogen receptor alpha
Type:EC50
SMILES:O=c1c(-c2ccc(O)cc2)c(Sc2ccc(O)cc2)oc2cc(O)ccc12
Value:=1860nM
Source:Homo sapiens
Assay:Binding affinity for Estrogen receptor alpha
Type:EC50
SMILES:O=c1c(-c2ccc(O)cc2)c(Oc2ccc(O)cc2)oc2cc(O)ccc12
Value:=1740nM
Source:Homo sapiens
Assay:Binding affinity for Estrogen receptor alpha
Type:EC50
SMILES:O=c1c(-c2ccc(O)cc2)c(Oc2ccc(OCCN3CCCCC3)cc2)oc2cc(O)ccc12
Value:=200nM
Source:Homo sapiens

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