Other Name(s): HER2, ErbB2, Epidermal Growth Factor Receptor 2
Assay:Inhibition of ligand induced proliferation in human Her-2 (p185erbB) tyrosine kinase expressing 3T3 cells
Type:IC50
SMILES:Cc1cc(C)c(/C=C2\C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c32)[nH]1
Value:=2500nM
Source:Homo sapiens
Assay:Inhibition of ligand induced proliferation in human Her-2 (p185erbB) tyrosine kinase expressing 3T3 cells
Type:IC50
SMILES:Cc1cc(C(=O)N2CCOCC2)[nH]c1/C=C1\C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c21
Value:=1210nM
Source:Homo sapiens
Assay:Inhibition of ligand induced proliferation in human Her-2 (p185erbB) tyrosine kinase expressing 3T3 cells
Type:IC50
SMILES:Cc1cc(C(=O)N2CCOCC2)[nH]c1/C=C1\C(=O)Nc2ncnc(Nc3ccc4c(c3)CCC4)c21
Value:=2780nM
Source:Homo sapiens
Assay:Inhibition of ligand induced proliferation in human Her-2 (p185erbB) tyrosine kinase expressing 3T3 cells
Type:IC50
SMILES:Cc1cc(C(=O)NCCN2CCOCC2)[nH]c1/C=C1\C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c21
Value:=1240nM
Source:Homo sapiens
Assay:Inhibition of ligand induced proliferation in human Her-2 (p185erbB) tyrosine kinase expressing 3T3 cells
Type:IC50
SMILES:CCN1CCN(C(=O)c2cc(C)c(/C=C3\C(=O)Nc4ncnc(Nc5ccc(F)c(Cl)c5)c43)[nH]2)CC1
Value:=350nM
Source:Homo sapiens
Assay:Inhibition of ligand induced proliferation in human Her-2 (p185erbB) tyrosine kinase expressing 3T3 cells
Type:IC50
SMILES:Cc1cc(C(=O)O)[nH]c1/C=C1\C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c21
Value:=49300nM
Source:Homo sapiens
Assay:Inhibition of ligand induced proliferation in human Her-2 (p185erbB) tyrosine kinase expressing 3T3 cells
Type:IC50
SMILES:Cc1cc(C(=O)N2CCN(C)CC2)[nH]c1/C=C1\C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c21
Value:=370nM
Source:Homo sapiens
Assay:Inhibition of ligand induced proliferation in human Her-2 (p185erbB) tyrosine kinase expressing 3T3 cells
Type:IC50
SMILES:C#Cc1cccc(Nc2ncnc3c2/C(=C/c2[nH]c(C(=O)NCCN4CCOCC4)cc2C)C(=O)N3)c1
Value:=500nM
Source:Homo sapiens
Assay:Inhibition of ligand induced proliferation in human Her-2 (p185erbB) tyrosine kinase expressing 3T3 cells
Type:IC50
SMILES:CCN(CC)CCNC(=O)c1cc(C)c(/C=C2\C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c32)[nH]1
Value:=370nM
Source:Homo sapiens
Assay:Inhibition of ligand induced proliferation in human Her-2 (p185erbB) tyrosine kinase expressing 3T3 cells
Type:IC50
SMILES:Cc1cc(C(=O)N2CC(C)NC(C)C2)[nH]c1/C=C1\C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c21
Value:=510nM
Source:Homo sapiens
Assay:Inhibition of ligand induced proliferation in human Her-2 (p185erbB) tyrosine kinase expressing 3T3 cells
Type:IC50
SMILES:Cc1cc(C(=O)NCCN2CCOCC2)[nH]c1/C=C1\C(=O)Nc2ncnc(Nc3ccc4c(ccn4Cc4ccccc4)c3)c21
Value:=1560nM
Source:Homo sapiens
Assay:Inhibition of erbB2 overexpressing BT474 (breast carcinoma) cell line proliferation
Type:IC50
SMILES:CS(=O)(=O)CCNCCCCOc1ccc2ncnc(Nc3ccc(F)c(Cl)c3)c2c1
Value:=1380nM
Source:Homo sapiens
Assay:Inhibition of erbB2 overexpressing BT474 (breast carcinoma) cell line proliferation
Type:IC50
SMILES:C#Cc1cccc(Nc2ncnc3ccc(OCCCCNCCS(C)(=O)=O)cc23)c1
Value:=1680nM
Source:Homo sapiens
Assay:Inhibition of erbB2 overexpressing BT474 (breast carcinoma) cell line proliferation
Type:IC50
SMILES:CS(=O)(=O)CCNCCCCOc1ccc2ncnc(Nc3ccc4c(cnn4Cc4cccc(F)c4)c3)c2c1
Value:=390nM
Source:Homo sapiens
Assay:Inhibition of erbB-2 overexpressing BT474 (Breast) tumor cell proliferation
Type:IC50
SMILES:CS(=O)(=O)CCNc1nc(-c2ccc3ncnc(Nc4ccc(OCc5ccccc5)c(Cl)c4)c3c2)cs1
Value:=280nM
Source:Homo sapiens
Assay:Inhibition of erbB-2 overexpressing BT474 (Breast) tumor cell proliferation
Type:IC50
SMILES:CS(=O)(=O)CCNc1nc(-c2ccc3ncnc(Nc4ccc(OCc5ccccc5)cc4)c3c2)cs1
Value:=860nM
Source:Homo sapiens
Assay:Inhibition of erbB-2 overexpressing BT474 (Breast) tumor cell proliferation
Type:IC50
SMILES:CS(=O)(=O)CCNc1nc(-c2ccc3ncnc(Nc4ccc5c(cnn5Cc5ccccc5)c4)c3c2)cs1
Value:=60nM
Source:Homo sapiens
Assay:Inhibition of erbB-2 overexpressing BT474 (Breast) tumor cell proliferation
Type:IC50
SMILES:CS(=O)(=O)CCNc1nc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(C(F)(F)F)c5)cc4)c3c2)cs1
Value:=15000nM
Source:Homo sapiens
Assay:Inhibition of erbB-2 overexpressing BT474 (Breast) tumor cell proliferation
Type:IC50
SMILES:CS(=O)(=O)CCNc1nc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)cs1
Value:=110nM
Source:Homo sapiens
Assay:Inhibition of erbB-2 overexpressing BT474 (Breast) tumor cell proliferation
Type:IC50
SMILES:CS(=O)(=O)CCNc1nc(-c2ccc3ncnc(Nc4ccc(F)c(Cl)c4)c3c2)cs1
Value:=2400nM
Source:Homo sapiens

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