 | | Assay: | Inhibition of human recombinant TRX-1 up to 60 mins by insulin reduction assay | | Type: | Ki | | SMILES: | CC(C)=CCC[C@]1(C)C=Cc2c(O)c3c(c(CC=C(C)C)c2O1)O[C@]12C(=C[C@@H]4C[C@H]1C(C)(C)O[C@@]2(C/C=C(/C)C(=O)O)C4=O)C3=O | | Value: | =3110nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of human recombinant thioredoxin-mediated TG2 activation expressed in T84 cells assessed as blockade of 5-biotinamidopentylamine incorporation after 3 hrs by fluorescence microscopic analysis | | Type: | IC50 | | SMILES: | Nn1c(SSC2CCCCC2)nnc1-c1ccccc1 | | Value: | =540nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of human recombinant thioredoxin-mediated TG2 activation expressed in T84 cells assessed as blockade of 5-biotinamidopentylamine incorporation after 3 hrs by fluorescence microscopic analysis | | Type: | IC50 | | SMILES: | c1ccc(-c2cnc(SSC3CCCCC3)[nH]2)cc1 | | Value: | =450nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of human recombinant thioredoxin-mediated TG2 activation expressed in T84 cells assessed as blockade of 5-biotinamidopentylamine incorporation after 3 hrs by fluorescence microscopic analysis | | Type: | IC50 | | SMILES: | Nc1nc(O)c2[nH]c(SSC3CCCCC3)nc2n1 | | Value: | =290nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of human recombinant thioredoxin-mediated TG2 activation expressed in T84 cells assessed as blockade of 5-biotinamidopentylamine incorporation after 3 hrs by fluorescence microscopic analysis | | Type: | IC50 | | SMILES: | O=C(c1ccccc1)c1ccc2nc(SSC3CCCCC3)[nH]c2c1 | | Value: | =240nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of human recombinant thioredoxin-mediated TG2 activation expressed in T84 cells assessed as blockade of 5-biotinamidopentylamine incorporation after 3 hrs by fluorescence microscopic analysis | | Type: | IC50 | | SMILES: | O=[N+]([O-])c1ccc2nc(SSC3CCCCC3)[nH]c2c1 | | Value: | =90nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of human recombinant thioredoxin-mediated TG2 activation expressed in T84 cells assessed as blockade of 5-biotinamidopentylamine incorporation after 3 hrs by fluorescence microscopic analysis | | Type: | IC50 | | SMILES: | Fc1cc2nc(SSC3CCCCC3)[nH]c2cc1Cl | | Value: | =170nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of human recombinant thioredoxin-mediated TG2 activation expressed in T84 cells assessed as blockade of 5-biotinamidopentylamine incorporation after 3 hrs by fluorescence microscopic analysis | | Type: | IC50 | | SMILES: | c1ccc2sc(SSC3CCCCC3)nc2c1 | | Value: | =510nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of human recombinant thioredoxin-mediated TG2 activation expressed in T84 cells assessed as blockade of 5-biotinamidopentylamine incorporation after 3 hrs by fluorescence microscopic analysis | | Type: | IC50 | | SMILES: | CC(C)(C)SSc1nc2ccccc2[nH]1 | | Value: | =7310nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of human recombinant thioredoxin-mediated TG2 activation expressed in T84 cells assessed as blockade of 5-biotinamidopentylamine incorporation after 3 hrs by fluorescence microscopic analysis | | Type: | IC50 | | SMILES: | CCSSc1nc2ccccc2[nH]1 | | Value: | =340nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of human recombinant thioredoxin-mediated TG2 activation expressed in T84 cells assessed as blockade of 5-biotinamidopentylamine incorporation after 3 hrs by fluorescence microscopic analysis | | Type: | IC50 | | SMILES: | CCC(C)SSc1ncc[nH]1 | | Value: | =2110nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of TR (unknown origin) assessed as reduction in enzyme-mediated bovine insulin aggregation after 30 mins by turbidimetric assay | | Type: | IC50 | | SMILES: | CCOC(=O)C1(CCOc2ccccc2)CCN(Cc2ccc(O)cc2)CC1 | | Value: | >30000nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of TR (unknown origin) assessed as reduction in enzyme-mediated bovine insulin aggregation after 30 mins by turbidimetric assay | | Type: | IC50 | | SMILES: | O=C(Nc1ccccc1)C1(CCOc2ccccc2)CCN(Cc2ccc(O)c(Cl)c2)CC1 | | Value: | >30000nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of TR (unknown origin) assessed as reduction in enzyme-mediated bovine insulin aggregation after 30 mins by turbidimetric assay | | Type: | IC50 | | SMILES: | O=C(NC1CCCC1)C1(CCOc2ccccc2)CCN(Cc2ccc(O)c(Cl)c2)CC1 | | Value: | >30000nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of TR (unknown origin) assessed as reduction in enzyme-mediated bovine insulin aggregation after 30 mins by turbidimetric assay | | Type: | IC50 | | SMILES: | CCN(C)C(=O)C1(CCOc2ccccc2)CCN(Cc2ccc(O)c(Cl)c2)CC1 | | Value: | >30000nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of TR (unknown origin) assessed as reduction in enzyme-mediated bovine insulin aggregation after 30 mins by turbidimetric assay | | Type: | IC50 | | SMILES: | CC(C)(C)OC(=O)C1(CCOc2ccccc2)CCN(Cc2ccc(O)c(Cl)c2)CC1 | | Value: | >30000nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of TR (unknown origin) assessed as reduction in enzyme-mediated bovine insulin aggregation after 30 mins by turbidimetric assay | | Type: | IC50 | | SMILES: | CC(C)OC(=O)C1(CCOc2ccccc2)CCN(Cc2ccc(O)c(Cl)c2)CC1 | | Value: | >30000nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of TR (unknown origin) assessed as reduction in enzyme-mediated bovine insulin aggregation after 30 mins by turbidimetric assay | | Type: | IC50 | | SMILES: | CCOC(=O)C1(CCOc2ccccc2)CCN(C(=O)c2ccc(O)c(Cl)c2)CC1 | | Value: | >30000nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of TR (unknown origin) assessed as reduction in enzyme-mediated bovine insulin aggregation after 30 mins by turbidimetric assay | | Type: | IC50 | | SMILES: | CCOC(=O)C1(CCOc2ccccc2)CCN(Cc2ccc(OC)c(Cl)c2)CC1 | | Value: | >30000nM | | Source: | Homo sapiens |
|
 | | Assay: | Inhibition of TR (unknown origin) assessed as reduction in enzyme-mediated bovine insulin aggregation after 30 mins by turbidimetric assay | | Type: | IC50 | | SMILES: | CCOC(=O)C1(CCOc2ccccc2)CCN(Cc2ccc(O)c(Cl)c2)CC1 | | Value: | >30000nM | | Source: | Homo sapiens |
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