Other Name(s): Tumor Necrosis Factor
Assay:Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCs
Type:IC50
SMILES:CNC(=O)[C@@H](NC(=O)[C@H](c1ccc(C)cc1)[C@H](CO)C(=O)NO)C(C)(C)C
Value:=269nM
Source:Homo sapiens
Assay:Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCs
Type:IC50
SMILES:CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C
Value:=1001nM
Source:Homo sapiens
Assay:Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCs
Type:IC50
SMILES:CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](CO)C(=O)NO)C(C)(C)C
Value:=1606nM
Source:Homo sapiens
Assay:Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCs
Type:IC50
SMILES:CNC(=O)[C@@H](NC(=O)[C@H](c1ccc(OC)cc1)[C@H](CO)C(=O)NO)C(C)(C)C
Value:=48nM
Source:Homo sapiens
Assay:Inhibitory activity against tumor necrosis factor alpha (TNF-alpha) production in LPS-stimulated human PBMCs
Type:IC50
SMILES:CNC(=O)[C@@H](NC(=O)[C@H](c1ccccc1)[C@H](CO)C(=O)NO)C(C)(C)C
Value:=928nM
Source:Homo sapiens
Assay:TNF-alpha production in PBMC by ELISA method
Type:IC50
SMILES:COc1ccc(C2CNC(=O)C2)cc1OC1CCCC1
Value:=12000nM
Source:
Assay:TNF-alpha production in PBMC by ELISA method
Type:IC50
SMILES:CCCCOc1cc(CC2CNC(=O)N2)ccc1OC
Value:=50000nM
Source:
Assay:TNF-alpha production in PBMC by ELISA method
Type:IC50
SMILES:CCOC(=O)CCCn1c(=O)c2c(nc(Br)n2C)n(C)c1=O
Value:=60000nM
Source:
Assay:TNF-alpha production in PBMC by ELISA method
Type:IC50
SMILES:CCOC(=O)CCCn1c(=O)c2nc(-c3ccccc3)cnc2n(C)c1=O
Value:>200000nM
Source:
Assay:TNF-alpha production in PBMC by ELISA method
Type:IC50
SMILES:Cn1c(=O)n(CCCC(=O)O)c(=O)c2nccnc21
Value:>200000nM
Source:
Assay:TNF-alpha production in PBMC by ELISA method
Type:IC50
SMILES:Cn1c(=O)n(CCCC(=O)O)c(=O)c2ccccc21
Value:>200000nM
Source:
Assay:TNF-alpha production in PBMC by ELISA method
Type:IC50
SMILES:CCCCCn1c(=O)n(CCCC(=O)OCC)c(=O)c2nccnc21
Value:=16000nM
Source:
Assay:TNF-alpha production in PBMC by ELISA method
Type:IC50
SMILES:CCCn1c(=O)n(CCCC(=O)OCC)c(=O)c2nccnc21
Value:=5000nM
Source:
Assay:TNF-alpha production in PBMC by ELISA method
Type:IC50
SMILES:CCOC(=O)CCCn1c(=O)c2nccnc2n(Cc2ccccc2)c1=O
Value:=175000nM
Source:
Assay:TNF-alpha production in PBMC by ELISA method
Type:IC50
SMILES:COC(=O)/C=C\Cn1c(=O)c2nccnc2n(C)c1=O
Value:=25000nM
Source:
Assay:TNF-alpha production in PBMC by ELISA method
Type:IC50
SMILES:CCCn1c(=O)n(CCCC(=O)O)c(=O)c2nccnc21
Value:>200000nM
Source:
Assay:TNF-alpha production in PBMC by ELISA method
Type:IC50
SMILES:CCOC(=O)CCCn1c(=O)c2nsnc2n(C)c1=O
Value:=25000nM
Source:
Assay:TNF-alpha production in PBMC by ELISA method
Type:IC50
SMILES:CCOC(=O)CCn1c(=O)c2c(ncn2C)n(C)c1=O
Value:=10000nM
Source:
Assay:TNF-alpha production in PBMC by ELISA method
Type:IC50
SMILES:CCOC(=O)CCCn1c(=O)c2nccnc2n(C)c1=O
Value:=12000nM
Source:
Assay:TNF-alpha production in PBMC by ELISA method
Type:IC50
SMILES:CCCCn1c(=O)n(CCCC(=O)OCC)c(=O)c2nccnc21
Value:=15000nM
Source:

Note: If you'd like to learn how our AI-powered BDE-Chem can help design therapeutic molecules against the TNF target, that break through the existing patents, at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai

Molecules for More Common Targets

ABCB1 | ABCG2 | ACE2 | AHR | AKT1 | ALK | AR | ATM | BAX | BCL2 | BCL2L1 | BRAF | BRCA1 | CASP3 | CASP9 | CCL5 | CCND1 | CD274 | CD4 | CDKN1A | CXCL8 | CXCR4 | DNMT1 | EGF | EGFR | EP300 | ERBB2 | ESR1 | EZH2 | FN1 | FOXO3 | HDAC9 | HGF | HMGB1 | HSP90AA1 | HSPA5 | IDO1 | IGF1 | IGF1R | IL17A | IL6 | INS | JUN | KRAS | MAPK1 | MAPK14 | MAPK3 | MAPK8 | MAPT | MCL1 | MMP9 | MTOR | MYC | NFE2L2 | NLRP3 | NOTCH1 | PARP1 | PCNA | PDCD1 | PLK1 | PRKAA1 | PRKAA2 | PTEN | PTGS2 | PTK2 | RELA | SIRT1 | SRC | STAT1 | STAT3 | STAT5A | TERT | TLR4 | TNF | TP53 | TXN | VEGFA | YAP1