Other Name(s): Anaplastic Lymphoma Kinase
Assay:Inhibitory activity against ALK
Type:IC50
SMILES:CN1CCN(CCc2ccc(NC(=O)c3cc(-c4ccc5c(c4)OCO5)cnc3O)cc2)CC1
Value:=400nM
Source:
Assay:Inhibitory activity against ALK
Type:Ki
SMILES:CN1CCN(CCc2ccc(NC(=O)c3cc(-c4ccc5c(c4)OCO5)cnc3O)cc2)CC1
Value:=200nM
Source:
Assay:Inhibitory activity against ALK
Type:IC50
SMILES:CN1CCN(Cc2ccc(NC(=O)c3cc(-c4ccc5c(c4)OCO5)cn(C)c3=O)cc2)CC1
Value:>40000nM
Source:
Assay:Inhibitory activity against ALK
Type:IC50
SMILES:CN1CCN(Cc2ccc(NC(=O)c3cc(-c4ccc5c(c4)OCO5)cnc3Cl)cc2)CC1
Value:=26800nM
Source:
Assay:Inhibitory activity against ALK
Type:IC50
SMILES:COc1ncc(-c2ccc3c(c2)OCO3)cc1C(=O)Nc1ccc(CN2CCN(C)CC2)cc1
Value:=20300nM
Source:
Assay:Inhibitory activity against ALK
Type:IC50
SMILES:Cc1cc(CN2CCN(C)CC2)ccc1NC(=O)c1cc(-c2ccc3c(c2)OCO3)cnc1O
Value:=14500nM
Source:
Assay:Inhibitory activity against ALK
Type:IC50
SMILES:COc1cc(CN2CCN(C)CC2)ccc1NC(=O)c1cc(-c2ccc3c(c2)OCO3)cnc1O
Value:=13800nM
Source:
Assay:Inhibitory activity against ALK
Type:IC50
SMILES:CN1CCN(Cc2ccc(N(C)C(=O)c3cc(-c4ccc5c(c4)OCO5)cnc3O)cc2)CC1
Value:=3700nM
Source:
Assay:Inhibitory activity against ALK
Type:IC50
SMILES:CN1CCN(Cc2ccc(NC(=O)c3cc(-c4ccncc4)cnc3O)cc2)CC1
Value:=19500nM
Source:
Assay:Inhibitory activity against ALK
Type:IC50
SMILES:COc1cc(-c2cnc(O)c(C(=O)Nc3ccc(CN4CCN(C)CC4)cc3)c2)cc(OC)c1OC
Value:=7500nM
Source:
Assay:Inhibitory activity against ALK
Type:IC50
SMILES:CN1CCN(Cc2ccc(NC(=O)c3cc(-c4ccc5nccnc5c4)cnc3O)cc2)CC1
Value:=5500nM
Source:
Assay:Inhibitory activity against ALK
Type:IC50
SMILES:Cc1nc2cc(-c3cnc(O)c(C(=O)Nc4ccc(CN5CCN(C)CC5)cc4)c3)ccc2s1
Value:=3800nM
Source:
Assay:Inhibitory activity against ALK
Type:IC50
SMILES:COc1ccc(-c2cnc(O)c(C(=O)Nc3ccc(CN4CCN(C)CC4)cc3)c2)cn1
Value:=3000nM
Source:
Assay:Inhibitory activity against ALK
Type:IC50
SMILES:CN1CCN(CCCc2ccc(NC(=O)c3cc(-c4ccc5c(c4)OCO5)cnc3O)cc2)CC1
Value:=1300nM
Source:
Assay:Inhibitory activity against ALK
Type:Ki
SMILES:CN1CCN(CCCc2ccc(NC(=O)c3cc(-c4ccc5c(c4)OCO5)cnc3O)cc2)CC1
Value:=1100nM
Source:
Assay:Inhibitory activity against ALK
Type:IC50
SMILES:CN1CCN(Cc2ccc(NC(=O)c3cc(-c4ccc5c(c4)OCO5)cnc3O)cc2)CC1
Value:=900nM
Source:
Assay:Inhibitory activity against ALK
Type:Ki
SMILES:CN1CCN(Cc2ccc(NC(=O)c3cc(-c4ccc5c(c4)OCO5)cnc3O)cc2)CC1
Value:=500nM
Source:
Assay:Inhibitory activity against ALK
Type:IC50
SMILES:CN1CCN(c2ccc(NC(=O)c3cc(-c4ccc5c(c4)OCO5)cnc3O)cc2)CC1
Value:=700nM
Source:
Assay:Inhibitory activity against ALK
Type:Ki
SMILES:CN1CCN(c2ccc(NC(=O)c3cc(-c4ccc5c(c4)OCO5)cnc3O)cc2)CC1
Value:=600nM
Source:
Assay:Decrease in ALK phosphorylation in human Karpas299 cells after 4 hrs
Type:IC50
SMILES:COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1
Value:<10nM
Source:Homo sapiens

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