Other Name(s): B-Raf
Assay:Inhibition of Protein kinase Raf-B binding in fluorescence polarization assay
Type:IC50
SMILES:Cc1cccc(-c2n[nH]cc2-c2ccc3ncccc3n2)n1
Value:>16000nM
Source:Homo sapiens
Assay:Inhibition bRaf kinase activity
Type:IC50
SMILES:CC(C)(C)c1nc(-c2ccc(F)cc2)c(-c2ccncc2)[nH]1
Value:=900nM
Source:Homo sapiens
Assay:Inhibition bRaf kinase activity
Type:IC50
SMILES:OCc1cccc(-c2[nH]c(-c3ccccc3)nc2-c2ccncc2)c1
Value:=1585nM
Source:Homo sapiens
Assay:Inhibition bRaf kinase activity
Type:IC50
SMILES:Oc1ccc(-c2[nH]c(-c3ccccc3)nc2-c2ccncc2)cc1
Value:=339nM
Source:Homo sapiens
Assay:Inhibition bRaf kinase activity
Type:IC50
SMILES:CC(C)(CNC(=O)Nc1ccc(Cl)cc1)c1nc(-c2ccc(Cl)c(O)c2)c(-c2ccncc2)[nH]1
Value:=13nM
Source:Homo sapiens
Assay:Inhibition bRaf kinase activity
Type:IC50
SMILES:CC(C)(CNS(C)(=O)=O)c1nc(-c2ccc(Cl)c(O)c2)c(-c2ccncc2)[nH]1
Value:=14nM
Source:Homo sapiens
Assay:Inhibition bRaf kinase activity
Type:IC50
SMILES:CN(C)CCCNC(=O)c1nc(-c2ccc(Cl)c(O)c2)c(-c2ccncc2)[nH]1
Value:=40nM
Source:Homo sapiens
Assay:Inhibition bRaf kinase activity
Type:IC50
SMILES:CC(C)(CN)c1nc(-c2ccc(Cl)c(O)c2)c(-c2ccncc2)[nH]1
Value:=6nM
Source:Homo sapiens
Assay:Inhibition bRaf kinase activity
Type:IC50
SMILES:NCc1ccc(-c2nc(-c3ccc(Cl)c(O)c3)c(-c3ccncc3)[nH]2)cc1
Value:=8nM
Source:Homo sapiens
Assay:Inhibition bRaf kinase activity
Type:IC50
SMILES:Oc1cc(-c2[nH]cnc2-c2ccncc2)ccc1Cl
Value:=33nM
Source:Homo sapiens
Assay:Inhibition bRaf kinase activity
Type:IC50
SMILES:Oc1cc(-c2[nH]c(-c3ccco3)nc2-c2ccncc2)ccc1Cl
Value:=13nM
Source:Homo sapiens
Assay:Inhibition bRaf kinase activity
Type:IC50
SMILES:Oc1cc(-c2[nH]c(-c3cccnc3)nc2-c2ccncc2)ccc1Cl
Value:=6nM
Source:Homo sapiens
Assay:Inhibition bRaf kinase activity
Type:IC50
SMILES:CC(C)(C)c1nc(-c2ccc(Cl)c(O)c2)c(-c2ccncc2)[nH]1
Value:=12nM
Source:Homo sapiens
Assay:Inhibition bRaf kinase activity
Type:IC50
SMILES:Oc1cc(-c2nc(-c3ccccc3)[nH]c2-c2ccncc2)ccc1Cl
Value:=10nM
Source:Homo sapiens
Assay:Binding affinity at bRaf kinase in fluorescent ligand displacement assay
Type:Kd
SMILES:Oc1cc(-c2nc(-c3ccccc3)[nH]c2-c2ccncc2)ccc1Cl
Value:=2.4nM
Source:Homo sapiens
Assay:Binding affinity at bRaf kinase in fluorescent ligand displacement assay
Type:Kd
SMILES:CN(C)CCOc1ccc(-c2nc(-c3ccncc3)c(-c3ccc4c(c3)CC/C4=N\O)[nH]2)cc1
Value:=0.3nM
Source:Homo sapiens
Assay:Binding affinity at bRaf kinase in fluorescent ligand displacement assay
Type:Kd
SMILES:O/N=C1/CCCc2cc(-c3[nH]c(-c4ccccc4)nc3-c3ccncc3)ccc21
Value:=17nM
Source:Homo sapiens
Assay:Binding affinity at bRaf kinase in fluorescent ligand displacement assay
Type:Kd
SMILES:O/N=C1/CCc2cc(-c3[nH]c(-c4ccccc4)nc3-c3ccncc3)ccc21
Value:=1.3nM
Source:Homo sapiens
Assay:Binding affinity at bRaf kinase in fluorescent ligand displacement assay
Type:Kd
SMILES:OC1CCc2cc(-c3[nH]c(-c4ccccc4)nc3-c3ccncc3)ccc21
Value:>200nM
Source:Homo sapiens
Assay:Binding affinity at bRaf kinase in fluorescent ligand displacement assay
Type:Kd
SMILES:N/C(=N\O)c1ccc(-c2[nH]c(-c3ccccc3)nc2-c2ccncc2)cc1
Value:=53nM
Source:Homo sapiens

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