Other Name(s): None
Assay:Inhibition of EZH2-mediated proliferation of human LNCaP cells after 6 days by chemiluminescence analysis
Type:IC50
SMILES:CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccnc(N3CCN(C)CC3)c2)cc2c1cnn2C(C)C
Value:=2900nM
Source:Homo sapiens
Assay:Inhibition of EZH2-mediated proliferation of human LNCaP cells after 6 days by chemiluminescence analysis
Type:IC50
SMILES:Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(N4CCN(C)CC4)nc3)cc3c2cnn3C(C)C)c(=O)[nH]1
Value:=4500nM
Source:Homo sapiens
Assay:Inhibition of EZH2-mediated nuclear H3K27 methylation in human HCC1806 cells after 72 hrs by immunofluorescence analysis
Type:IC50
SMILES:CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccnc(N3CCN(C)CC3)c2)cc2c1cnn2C(C)C
Value:=174nM
Source:Homo sapiens
Assay:Inhibition of EZH2-mediated nuclear H3K27 methylation in human HCC1806 cells after 72 hrs by immunofluorescence analysis
Type:IC50
SMILES:Cc1cc(C)c(CNC(=O)c2cc(-c3ccnc(N4CCN(C)CC4)c3)cc3c2cnn3C(C)C)c(=O)[nH]1
Value:=1995nM
Source:Homo sapiens
Assay:Inhibition of EZH2-mediated nuclear H3K27 methylation in human HCC1806 cells after 72 hrs by immunofluorescence analysis
Type:IC50
SMILES:CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCN(C)CC3)nc2)cc2c1cnn2C(C)C
Value:=79nM
Source:Homo sapiens
Assay:Inhibition of EZH2-mediated nuclear H3K27 methylation in human HCC1806 cells after 72 hrs by immunofluorescence analysis
Type:IC50
SMILES:Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(N4CCN(C)CC4)nc3)cc3c2cnn3C(C)C)c(=O)[nH]1
Value:=324nM
Source:Homo sapiens
Assay:Inhibition of EZH2-mediated nuclear H3K27 methylation in human HCC1806 cells after 72 hrs by immunofluorescence analysis
Type:IC50
SMILES:Cc1cc(C)c(CNC(=O)c2cc(C3CC3)cc3c2cnn3C(C)C)c(=O)[nH]1
Value:=2510nM
Source:Homo sapiens
Assay:Inhibition of EZH2-mediated nuclear H3K27 methylation in human HCC1806 cells after 72 hrs by immunofluorescence analysis
Type:IC50
SMILES:Cc1cc(C)c(CNC(=O)c2cc(C3CC3)nc3c2cnn3C(C)C)c(O)n1
Value:=10632nM
Source:Homo sapiens
Assay:Inhibition of wild type EZH2 (unknown origin)
Type:IC50
SMILES:CC1(C)CC(NC(=O)c2ccc(Oc3ccccc3)cc2)CC(C)(C)N1
Value:=51000nM
Source:Homo sapiens
Assay:Inhibition of wild type EZH2 (unknown origin)
Type:IC50
SMILES:CC1(C)CC(NC(=O)c2ccc(COc3ccccc3)cc2)CC(C)(C)N1
Value:=48000nM
Source:Homo sapiens
Assay:Inhibition of wild type EZH2 (unknown origin)
Type:IC50
SMILES:CC1(C)CC(NC(=O)c2ccc(OCc3ccccc3)cc2)CC(C)(C)N1
Value:>80000nM
Source:Homo sapiens
Assay:Inhibition of wild type EZH2 (unknown origin)
Type:IC50
SMILES:CC1(C)CC(NC(=O)c2ccc(Sc3ccccc3)cc2)CC(C)(C)N1
Value:=33000nM
Source:Homo sapiens
Assay:Inhibition of wild type EZH2 (unknown origin)
Type:IC50
SMILES:CC1(C)CC(NC(=O)c2ccc([S+]([O-])c3ccccc3)cc2)CC(C)(C)N1
Value:>80000nM
Source:Homo sapiens
Assay:Inhibition of wild type EZH2 (unknown origin)
Type:IC50
SMILES:CC1(C)CC(NC(=O)c2ccc(S(=O)(=O)c3ccccc3)cc2)CC(C)(C)N1
Value:>80000nM
Source:Homo sapiens
Assay:Inhibition of wild type EZH2 (unknown origin)
Type:IC50
SMILES:CC1(C)CC(NC(=O)c2ccc(C(=O)c3ccccc3)cc2)CC(C)(C)N1
Value:=57000nM
Source:Homo sapiens
Assay:Inhibition of wild type EZH2 (unknown origin)
Type:IC50
SMILES:CC1(C)CC(NC(=O)c2ccc(C(O)c3ccccc3)cc2)CC(C)(C)N1
Value:>80000nM
Source:Homo sapiens
Assay:Inhibition of wild type EZH2 (unknown origin)
Type:IC50
SMILES:CC1(C)CC(NC(=O)c2ccc(Nc3ccccc3)cc2)CC(C)(C)N1
Value:>80000nM
Source:Homo sapiens
Assay:Inhibition of wild type EZH2 (unknown origin)
Type:IC50
SMILES:CN(c1ccccc1)c1ccc(C(=O)NC2CC(C)(C)NC(C)(C)C2)cc1
Value:>80000nM
Source:Homo sapiens
Assay:Inhibition of wild type EZH2 (unknown origin)
Type:IC50
SMILES:CC1(C)CC(NC(=O)c2ccc(Cc3ccccc3)cc2)CC(C)(C)N1
Value:>80000nM
Source:Homo sapiens
Assay:Inhibition of wild type EZH2 (unknown origin)
Type:IC50
SMILES:CC(c1ccccc1)c1ccc(C(=O)NC2CC(C)(C)NC(C)(C)C2)cc1
Value:>80000nM
Source:Homo sapiens

Note: If you'd like to learn how our AI-powered BDE-Chem can help design therapeutic molecules against the EZH2 target, that break through the existing patents, at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai

Molecules for More Common Targets

ABCB1 | ABCG2 | ACE2 | AHR | AKT1 | ALK | AR | ATM | BAX | BCL2 | BCL2L1 | BRAF | BRCA1 | CASP3 | CASP9 | CCL5 | CCND1 | CD274 | CD4 | CDKN1A | CXCL8 | CXCR4 | DNMT1 | EGF | EGFR | EP300 | ERBB2 | ESR1 | EZH2 | FN1 | FOXO3 | HDAC9 | HGF | HMGB1 | HSP90AA1 | HSPA5 | IDO1 | IGF1 | IGF1R | IL17A | IL6 | INS | JUN | KRAS | MAPK1 | MAPK14 | MAPK3 | MAPK8 | MAPT | MCL1 | MMP9 | MTOR | MYC | NFE2L2 | NLRP3 | NOTCH1 | PARP1 | PCNA | PDCD1 | PLK1 | PRKAA1 | PRKAA2 | PTEN | PTGS2 | PTK2 | RELA | SIRT1 | SRC | STAT1 | STAT3 | STAT5A | TERT | TLR4 | TNF | TP53 | TXN | VEGFA | YAP1