Other Name(s): MDR1, Pgp, P-gp, P-glycoprotein
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:CNc1ccc(-c2[nH]c(-c3ccc(/C=C/C(=O)OC)cc3)nc2-c2ccc(NC(C)C)cc2)cc1
Value:=0.12uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:CCCN(CCC)c1ccc(-c2c[nH]c(-c3ccc(/C=C/COCC)cc3)n2)cc1
Value:=0.28uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:CCOC/C=C/c1ccc(-c2nc(-c3ccc(NC(C)C)cc3)c(-c3ccc(NC)cc3)[nH]2)cc1
Value:=0.05uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:CCOC/C=C/c1ccc(-c2nc(-c3ccc(NC)cc3)c(-c3ccc(N4CCCC4)cc3)[nH]2)cc1
Value:=0.15uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:CCN(CC)c1ccc(-c2[nH]c(-c3ccc(/C=C/C(=O)OC)cc3)nc2-c2cccc(N(CC)CC)c2)cc1
Value:=0.57uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:COC(=O)/C=C/c1ccc(-c2nc(-c3ccc(N)cc3)c(-c3ccc(N(C)C)cc3)[nH]2)cc1
Value:=0.59uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:CCOC/C=C/c1ccc(-c2nc(-c3ccc(N(CC)CC)cc3)c(-c3ccc(N(CC)CC)cc3)[nH]2)cc1
Value:=0.26uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:CNc1ccc(-c2nc(-c3ccc(/C=C/C(=O)OC)cc3)[nH]c2-c2ccc(NC)cc2)cc1
Value:=0.2uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:CCNc1ccc(-c2[nH]c(-c3ccc(/C=C/COCC)cc3)nc2-c2ccc(NC(C)C)cc2)cc1
Value:=0.05uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:COC(=O)/C=C/c1ccc(-c2nc(-c3ccc(N(C)C)cc3)c(-c3ccc(N(C)C)cc3)[nH]2)cc1
Value:=0.3uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:CCOC/C=C/c1ccc(-c2nc(-c3ccc(N4CCOCC4)cc3)c[nH]2)cc1
Value:=0.37uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:C=CCN(CC=C)c1ccc(-c2nc(-c3ccc(/C=C/C(=O)OC)cc3)[nH]c2-c2cccc(N(CC=C)CC=C)c2)cc1
Value:=5.5uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:CCOCC/C=C/c1ccc(-c2nc(-c3ccc(NC)cc3)c(-c3ccc(N(CC)CC)cc3)[nH]2)cc1
Value:=0.06uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:CCN(CC)c1ccc(-c2[nH]c(-c3ccc(/C=C/C(=O)OC)cc3)nc2-c2ccc(NC)cc2)cc1
Value:=0.07uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:CCOC/C=C/c1ccc(-c2nc(-c3ccc(N4CCOCC4)cc3)c(-c3ccc(N4CCOCC4)cc3)[nH]2)cc1
Value:=0.22uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:CCOC/C=C/c1ccc(-c2nc(-c3ccc(NC(C)C)cc3)c(-c3ccc(NC(C)C)cc3)[nH]2)cc1
Value:=0.05uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:COC(=O)/C=C/c1ccc(-c2nc(-c3ccc(N4CCCC4)cc3)c(-c3ccc(N4CCCC4)cc3)[nH]2)cc1
Value:=0.37uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:CCN(CC)c1ccc(-c2[nH]c(-c3ccc(/C=C/C(=O)OC)cc3)nc2-c2ccc(N)cc2)cc1
Value:=0.31uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:CNc1ccc(-c2[nH]c(-c3ccc(/C=C/CCOC)cc3)nc2-c2ccc(N(C)C)cc2)cc1
Value:=0.11uM
Source:Homo sapiens
Assay:Modulation of Pgp (P-glycoprotein) mediated multidrug resistance in CEM / VLB 1000 cell line
Type:ED50
SMILES:CCOC/C=C/c1ccc(-c2nc(-c3ccc(NC(C)C)cc3)c[nH]2)cc1
Value:=0.34uM
Source:Homo sapiens

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