Other Name(s): None
Assay:Inhibition of ligand-induced proliferation in human EGF-R Kinase expressing 3T3 cells
Type:IC50
SMILES:Cc1cc(C)c(/C=C2\C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c32)[nH]1
Value:=7820nM
Source:Homo sapiens
Assay:Inhibition of ligand-induced proliferation in human EGF-R Kinase expressing 3T3 cells
Type:IC50
SMILES:Cc1cc(C(=O)N2CCOCC2)[nH]c1/C=C1\C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c21
Value:=440nM
Source:Homo sapiens
Assay:Inhibition of ligand-induced proliferation in human EGF-R Kinase expressing 3T3 cells
Type:IC50
SMILES:Cc1cc(C(=O)N2CCOCC2)[nH]c1/C=C1\C(=O)Nc2ncnc(Nc3ccc4c(c3)CCC4)c21
Value:=4320nM
Source:Homo sapiens
Assay:Inhibition of ligand-induced proliferation in human EGF-R Kinase expressing 3T3 cells
Type:IC50
SMILES:Cc1cc(C(=O)NCCN2CCOCC2)[nH]c1/C=C1\C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c21
Value:=2050nM
Source:Homo sapiens
Assay:Inhibition of ligand-induced proliferation in human EGF-R Kinase expressing 3T3 cells
Type:IC50
SMILES:CCN1CCN(C(=O)c2cc(C)c(/C=C3\C(=O)Nc4ncnc(Nc5ccc(F)c(Cl)c5)c43)[nH]2)CC1
Value:=7500nM
Source:Homo sapiens
Assay:Inhibition of ligand-induced proliferation in human EGF-R Kinase expressing 3T3 cells
Type:IC50
SMILES:Cc1cc(C(=O)O)[nH]c1/C=C1\C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c21
Value:>50000nM
Source:Homo sapiens
Assay:Inhibition of ligand-induced proliferation in human EGF-R Kinase expressing 3T3 cells
Type:IC50
SMILES:Cc1cc(C(=O)N2CCN(C)CC2)[nH]c1/C=C1\C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c21
Value:=750nM
Source:Homo sapiens
Assay:Inhibition of ligand-induced proliferation in human EGF-R Kinase expressing 3T3 cells
Type:IC50
SMILES:C#Cc1cccc(Nc2ncnc3c2/C(=C/c2[nH]c(C(=O)NCCN4CCOCC4)cc2C)C(=O)N3)c1
Value:=620nM
Source:Homo sapiens
Assay:Inhibition of ligand-induced proliferation in human EGF-R Kinase expressing 3T3 cells
Type:IC50
SMILES:CCN(CC)CCNC(=O)c1cc(C)c(/C=C2\C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c32)[nH]1
Value:=1290nM
Source:Homo sapiens
Assay:Inhibition of ligand-induced proliferation in human EGF-R Kinase expressing 3T3 cells
Type:IC50
SMILES:Cc1cc(C(=O)N2CC(C)NC(C)C2)[nH]c1/C=C1\C(=O)Nc2ncnc(Nc3ccc(F)c(Cl)c3)c21
Value:=2580nM
Source:Homo sapiens
Assay:Inhibition of ligand-induced proliferation in human EGF-R Kinase expressing 3T3 cells
Type:IC50
SMILES:Cc1cc(C(=O)NCCN2CCOCC2)[nH]c1/C=C1\C(=O)Nc2ncnc(Nc3ccc4c(ccn4Cc4ccccc4)c3)c21
Value:=1950nM
Source:Homo sapiens
Assay:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells.
Type:IC50
SMILES:Nc1ccc(Nc2[nH]nc3ncnc(Nc4cccc(Cl)c4)c23)cc1
Value:=500nM
Source:
Assay:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells.
Type:IC50
SMILES:O=[N+]([O-])c1cccc(-c2[nH]nc3ncnc(Nc4cccc(Cl)c4)c23)c1
Value:>100000nM
Source:
Assay:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells.
Type:IC50
SMILES:c1ccc(Nc2nc[nH]c3nnc(Nc4ccccc4)c2-3)cc1
Value:=12000nM
Source:
Assay:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells.
Type:IC50
SMILES:Nc1cccc(-c2[nH]nc3ncnc(Nc4cccc(Cl)c4)c23)c1
Value:=800nM
Source:
Assay:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells.
Type:IC50
SMILES:COc1cccc(Nc2[nH]nc3ncnc(Nc4cccc(Cl)c4)c23)c1
Value:=800nM
Source:
Assay:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells.
Type:IC50
SMILES:COc1ccc(CNc2[nH]nc3ncnc(Nc4cccc(Cl)c4)c23)cc1
Value:=20nM
Source:
Assay:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells.
Type:IC50
SMILES:CN(C)c1ccc(Nc2[nH]nc3ncnc(Nc4cccc(Cl)c4)c23)cc1
Value:=1500nM
Source:
Assay:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells.
Type:IC50
SMILES:Clc1cccc(Nc2[nH]cnc3nnc(NCc4ccccc4)c2-3)c1
Value:=3nM
Source:
Assay:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells.
Type:IC50
SMILES:Nc1[nH]cnc2nnc(Nc3cccc(Cl)c3)c1-2
Value:=35000nM
Source:

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