Other Name(s): COX-2, Cyclooxygenase-2
Assay:In vitro inhibitory activity against human Prostaglandin G/H synthase 2 (66 nM) using [14C]-AA (50 uM) was determined
Type:IC50
SMILES:COc1ccc2c(c1)c(CC(=O)NCCc1ccccc1)c(C)n2Cc1ccc(Br)cc1
Value:>66000nM
Source:
Assay:In vitro inhibitory activity against human Prostaglandin G/H synthase 2 (66 nM) using [14C]-AA (50 uM) was determined
Type:IC50
SMILES:COc1ccc2c(c1)c(CC(=O)OCCc1ccccc1)c(C)n2Cc1ccc(Br)cc1
Value:>66000nM
Source:
Assay:In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.
Type:IC50
SMILES:CS(=O)(=O)c1ccc(C2=C(c3ccc(F)c(Cl)c3)C(=O)CC2)cc1
Value:=90nM
Source:
Assay:In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.
Type:IC50
SMILES:COc1ccncc1C1=C(c2ccc(S(C)(=O)=O)cc2)CCC1=O
Value:=90nM
Source:
Assay:In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.
Type:IC50
SMILES:CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)CC2)cc1
Value:=190nM
Source:
Assay:In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.
Type:IC50
SMILES:CS(=O)(=O)c1ccc(C2=C(c3cccnc3)C(=O)CC2)cc1
Value:=640nM
Source:
Assay:In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.
Type:IC50
SMILES:CS(=O)(=O)c1ccc(C2=C(Oc3cc(F)cc(F)c3)C(=O)CC2)cc1
Value:=1100nM
Source:
Assay:In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.
Type:IC50
SMILES:CS(=O)(=O)c1ccc(C2=C(c3cc(Br)ccn3)C(=O)CC2)cc1
Value:=470nM
Source:
Assay:In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.
Type:IC50
SMILES:Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1
Value:=1000nM
Source:
Assay:In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.
Type:IC50
SMILES:CS(=O)(=O)c1ccc(C2=C(c3cccc(F)c3)C(=O)CC2)cc1
Value:=340nM
Source:
Assay:In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.
Type:IC50
SMILES:CS(=O)(=O)c1ccc(C2=C(c3ccc(F)c(F)c3)C(=O)CC2)cc1
Value:=210nM
Source:
Assay:In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.
Type:IC50
SMILES:CS(=O)(=O)c1ccc(C2=C(c3ccc(Cl)c(F)c3)C(=O)CC2)cc1
Value:=150nM
Source:
Assay:In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.
Type:IC50
SMILES:CS(=O)(=O)c1ccc(C2=C(c3cc4ccccc4s3)C(=O)CC2)cc1
Value:=80nM
Source:
Assay:In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.
Type:IC50
SMILES:CS(=O)(=O)c1ccc(C2=C(c3cc(F)cc(F)c3)C(=O)CC2)cc1
Value:=620nM
Source:
Assay:In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.
Type:IC50
SMILES:CS(=O)(=O)c1ccc(C2=C(c3cc(Cl)ccn3)C(=O)CC2)cc1
Value:=520nM
Source:
Assay:In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.
Type:IC50
SMILES:Cc1ccncc1C1=C(c2ccc(S(C)(=O)=O)cc2)CCC1=O
Value:=450nM
Source:
Assay:In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.
Type:IC50
SMILES:CS(=O)(=O)c1ccc(C2=C(C#Cc3ccccc3)C(=O)CC2)cc1
Value:=640nM
Source:
Assay:In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.
Type:IC50
SMILES:CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1
Value:=500nM
Source:
Assay:In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.
Type:IC50
SMILES:CS(=O)(=O)c1ccc(C2=C(c3cc(Cl)c(Cl)c(Cl)c3)C(=O)CC2)cc1
Value:=930nM
Source:
Assay:In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.
Type:IC50
SMILES:CC(C)(C)C#CC1=C(c2ccc(S(C)(=O)=O)cc2)CCC1=O
Value:=5200nM
Source:

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