Other Name(s): HTERT, Telomerase Reverse Transcriptase
Assay:In vitro antiproliferative activity of compound against HT-29 (human colon caner ) cell line was determined by SRB assay
Type:IC50
SMILES:N#Cc1ccc(C=O)nc1SCc1c(Cl)cccc1Cl
Value:=113280nM
Source:
Assay:In vitro antiproliferative activity of compound against HT-29 (human colon caner ) cell line was determined by SRB assay
Type:IC50
SMILES:O=Cc1cccc(C(=O)Sc2ccc(Cl)c(Cl)c2)n1
Value:=33090nM
Source:
Assay:Inhibitory activity against Telomerase evaluated by TRAP Assay studies.
Type:IC50
SMILES:CC1(C)CC2CC(C)(CN2CCC(=O)Nc2ccc3cc4ccc(NC(=O)CCN5CC6(C)CC5CC(C)(C)C6)cc4nc3c2)C1
Value:>50000nM
Source:
Assay:Inhibitory activity against Telomerase evaluated by TRAP Assay studies.
Type:IC50
SMILES:O=C(CCN1CCCCC1)Nc1ccc2c(c1)C(=O)c1ccc(NC(=O)CCN3CCCCC3)cc1C2=O
Value:=4500nM
Source:
Assay:Inhibitory activity against Telomerase evaluated by TRAP Assay studies.
Type:IC50
SMILES:O=C(CCN1CCCC1)Nc1ccc2cc3ccc(NC(=O)CCN4CCCC4)cc3nc2c1
Value:=5200nM
Source:
Assay:Inhibitory activity against Telomerase evaluated by TRAP Assay studies.
Type:IC50
SMILES:O=C(CCN1CCCCCCC1)Nc1ccc2cc3ccc(NC(=O)CCN4CCCCCCC4)cc3nc2c1
Value:>50000nM
Source:
Assay:Inhibitory activity against Telomerase evaluated by TRAP Assay studies.
Type:IC50
SMILES:O=C(CCN1CCCCC1)Nc1ccc2cc3ccc(NC(=O)CCN4CCCCC4)cc3nc2c1
Value:=2800nM
Source:
Assay:Inhibitory activity against Telomerase evaluated by TRAP Assay studies.
Type:IC50
SMILES:CC1(C)CC2CC(C)(CN2CCC(=O)Nc2ccc3c(c2)C(=O)c2ccc(NC(=O)CCN4CC5(C)CC4CC(C)(C)C5)cc2C3=O)C1
Value:>50000nM
Source:
Assay:Inhibitory activity against Telomerase evaluated by TRAP Assay studies.
Type:IC50
SMILES:O=C(CCN1CCCCCCC1)Nc1ccc2c(c1)C(=O)c1ccc(NC(=O)CCN3CCCCCCC3)cc1C2=O
Value:>50000nM
Source:
Assay:Inhibitory activity against Telomerase evaluated by TRAP Assay studies.
Type:IC50
SMILES:O=C(CCN1CCCCCC1)Nc1ccc2cc3ccc(NC(=O)CCN4CCCCCC4)cc3nc2c1
Value:=3100nM
Source:
Assay:Inhibitory activity against Telomerase evaluated by TRAP Assay studies.
Type:IC50
SMILES:O=C(CCN1CCCC1)Nc1ccc2c(c1)C(=O)c1ccc(NC(=O)CCN3CCCC3)cc1C2=O
Value:=1800nM
Source:
Assay:Inhibitory activity against Telomerase evaluated by TRAP Assay studies.
Type:IC50
SMILES:O=C(CCN1CCCCCC1)Nc1ccc2c(c1)C(=O)c1ccc(NC(=O)CCN3CCCCCC3)cc1C2=O
Value:=13000nM
Source:
Assay:Inhibitory activity against human telomerase
Type:EC50
SMILES:O=C(CCN1CCCC1)Nc1ccc2cc3ccc(NC(=O)CCN4CCCC4)cc3nc2c1
Value:=5200nM
Source:
Assay:Inhibitory activity against human telomerase
Type:EC50
SMILES:COCCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12
Value:=140nM
Source:
Assay:Inhibitory activity against human telomerase
Type:EC50
SMILES:CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Value:=115nM
Source:
Assay:Inhibitory activity against human telomerase
Type:EC50
SMILES:COc1ccc(Nc2c3cc(NC(=O)CCN4CCCC4)ccc3nc3ccc(NC(=O)CCN4CCCC4)cc23)cc1
Value:=460nM
Source:
Assay:Inhibitory activity against human telomerase
Type:EC50
SMILES:CC(=O)Nc1cccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)c1
Value:=100nM
Source:
Assay:Inhibitory activity against human telomerase
Type:EC50
SMILES:O=C(CCN1CCCC1)Nc1ccc2c(NC3CCCCC3)c3cc(NC(=O)CCN4CCCC4)ccc3nc2c1
Value:=210nM
Source:
Assay:Inhibitory activity against human telomerase
Type:EC50
SMILES:CN(C)c1ccc(Nc2c3cc(NC(=O)CCN4CCCC4)ccc3nc3ccc(NC(=O)CCN4CCCC4)cc23)cc1
Value:=500nM
Source:
Assay:Inhibitory activity against human telomerase
Type:EC50
SMILES:Nc1ccc(Nc2c3cc(NC(=O)CCN4CCCC4)ccc3nc3ccc(NC(=O)CCN4CCCC4)cc23)cc1
Value:=200nM
Source:

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