Dermatitis

About the Disease
Dermatitis, also known as eczema, is related to irritant dermatitis and dermatitis herpetiformis, and has symptoms including exanthema and pruritus. An important gene associated with Dermatitis is FLG (Filaggrin), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Salicylic acid and Titanium dioxide have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and t cells, and related phenotypes are immune system and hematopoietic system

Common Targets
G595 | CCR10 | G29126 | Interleukin 17 (nonspecified subtype) | G3309 | PROC | IL36RN | G1026 | F2RL1 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | Serine/Threonine Kinase (nonspecified subtype) | PDE4B | IKBKB | NR1H2 | FKBP1A | Interleukin-1 (nonspecified subtype) | CANX | PPARA | TYK2 | ALOX5AP | FLG | IL-10 Receptor | G1029 | TYR | TRPM8 | PPP3R2 | PPP3CC | TRAF6 | DYRK1A | ABCA1 | TNFSF10 | alpha-Adrenoceptor (nonspecified subtype) | IL-4 receptor | CCR2 | TRPV1 | G7124 | SYK | G6772 | PTPN1 | NTRK1 | Neurotrophic Tyrosine Kinase Receptor (TRK) (nonspecified subtype) | GSK3B | NR3C1 | TSLP | Mitogen-Activated Protein Kinase (nonspecified subtype) | Platelet-Derived Growth Factor Receptor (nonspecified subtype) | DSP | IL5 | G4193 | PTGDR2 | NFKBIL1 | VDR | beta-Adrenoceptor (nonspecified subtype) | IL1A | IL2 | Caspase (nonspecified subtype) | Serine protease (nonspecified subtype) | EPHA2 | IFNG | VCP | IL1RL2 | HRH1 | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 (nonspecified protein) | Cyclooxygenase (COX) (nonspecified subtype) | PPP3CB | NAMPT | CYSLTR2 | CLEC12B | PDE4A | PPP3R1 | Retinoid RXR receptor (nonspecified subtype) | APC | IL1B | TNIP1 | LTC4S | IL4 | KRR1 | JAK3 | ALOX5 | CALCR | G3569 | IL-13 receptor | JAK1 | CTNNB1 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | WNT2 | JAK2 | RIPK1 | S1PR1 | IL13 | PIK3CG | G3576 | DSG1 | HRH4 | TGFBR2 | SIK3 | DPYD | G6714 | Superoxide dismutase (SOD) (nonspecified subtype) | G6647 | G5133 | XBP1 | RIPK2 | PDE4D | HSP90B1 | Protein Phosphatase 2B | RORC

Note: If you'd like to get a target analysis report for Dermatitis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Dermatitis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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