Major Depression

About the Disease
Major Depressive Disorder, also known as seasonal affective disorder, is related to anxiety and endogenous depression, and has symptoms including affective symptoms, behavioral symptoms and schizophrenic language. An important gene associated with Major Depressive Disorder is HTR2A (5-Hydroxytryptamine Receptor 2A), and among its related pathways/superpathways are Signal Transduction and Neuroscience. The drugs Fluvoxamine and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and cortex, and related phenotypes are depression and behavior/neurological

Common Targets
ACTA2 | ABCA13 | Glutamate Receptor Ionotropic AMPA Receptor | ZNF366 | CSNK1E | ANKRD12 | CX3CL1 | NF2 | DDC | CNTN5 | HRH3 | MIRLET7I | CHN2 | GPR139 | Microtubule-Associated Protein (nonspecified subtype) | G3620 | ITIH1 | 5-Hydroxytryptamine Receptor 3 (5-HT3 receptor) (nonspecified subtype) | GNAI3 | TMEM106B | PLCD4 | TENM2 | Nicotinic alpha4beta2alpha5 Receptor | CD247 | FFAR4 | BDNF | MIP | SEMA5A | NF-kappaB (NFkB) | MAD1L1 | SLC7A6OS | TOMM40 | Corticotropin-Releasing Factor (CRF) Receptor (nonspecified subtype) | MTERF2 | EFR3B | FADS2 | Nicotinic alpha6beta2alpha4beta2beta3 receptor | ELL2 | RBFOX1 | SP4 | TACR2 | NGFR | PCYT1B | GABRA4 | GCH1 | TTC12 | ELOC | SLC18A2 | GRIK1 | GRM5 | NR3C2 | STIP1 | CRY2 | CYP2D6 | RAI1 | CYP2C19 | ITIH3 | G7099 | MYT1L | LOC101927825 | NOS1 | OPRK1 | PDE4B | RGS13 | MTNR1A | SKA2 | IL2RA | Folate Receptor (nonspecified subtype) | ANO4 | SRR | THRB | SYNE2 | CAVIN3 | OPRM1 | ADRA1A | DRD4 | NCAM1 | G5594 | HSD17B10 | AKR1C2 | CDC73 | GNB3 | LRFN5 | ACE | YWHAE | DAOA | PTPRZ1 | Neuropeptide Y receptor (NPY-R) (nonspecified subtype) | G1950 | GAL | MGLL | PDE8B | NRG1 | T-Type Calcium Channel | CYP17A1 | ALDH2 | GRIA1 | G1432 | PDE6A | SIGMAR1 | IL19 | KCNQ3 | PPARA | AVPR1B | CRH | ABCB6 | DROSHA | Alpha-2 Adrenergic receptors (nonspecified subtype) | ZEB2 | TRPC5 | IMMP2L | MAPK11 | ITIH4 | SESN2 | GABRB2 | GABRG2 | LOC105373657 | RCL1 | MAOA | ESR2 | PDE1C | LOC105373659 | MTHFS | CHRM1 | BCR | DRD2 | NDUFV2 | TSNAX-DISC1 | RSRC1 | CDKAL1 | MCTP1 | ANKK1 | COMT | TRPM1 | EHD3 | SORCS3 | GRIK2 | MIR34B | WWOX | DISC1 | ABCG1 | HTR4 | TCF4 | DAOA-AS1 | PDE10A | DBH | SPECC1L-ADORA2A | CACNB2 | LOC105377864 | HCRTR1 | KCNK2 | HTR1A | ARRB1 | RPS6KL1 | SLC6A15 | GRIA2 | GRM2 | SLC6A2 | RERE | GALR3 | PPP3CC | Glutamate Transporter (nonspecified subtype) | G23411 | FPGT-TNNI3K | G1385 | HOATZ | PDE9A | CDKN2B-AS1 | DNAJC15 | DOK7 | HS3ST1 | HTR2B | Neurotrophic Factor (nonspecified subtype) | CNR1 | EFCAB13-DT | METTL14 | CLU | Nicotinic alpha3beta4 Receptor | FHIT | BICC1 | STEAP2-AS1 | Opioid receptor (nonspecified subtype) | PDE6C | CACNA1C | TNNI3K | NPY2R | UCHL5 | TIMELESS | SOD2 | CRHBP | GABA(A) receptor | RFK | GLS | GRM7 | HSD11B1 | CHRNA7 | Nicotinic alpha4beta2 receptor | ADRB3 | HTR5A | G4137 | PTGS1 | MIR34C | MTNR1B | ITGA11 | PIPOX | BRD1 | RIMS2 | TRHDE | ADORA2A | ADRA2A | MIR124-1 | PCDH9 | TOX2 | LINC01876 | SYT9 | FAM24B | RAPGEF4 | BTN3A2 | SEPSECS | GIPR | LOC107983986 | NRGN | GRIA4 | OXT | PPFIA4 | TTTY14 | OPRL1 | Tubulin | ACHE | SHISA9 | GSK3B | NPY | FKBP5 | CLIC4 | Voltage-Gated Sodium Channel Complex | ATXN7L2 | RORA | RGS18 | ATG9A | GABRP | GRIN2A | SOX5 | DLG4 | ZNF804A | TSPO | FGFR1 | PRL | GABRB3 | PLAT | TFAP2B | OPRD1 | MIR124-2 | AGPAT4 | Mitogen-Activated Protein Kinase (nonspecified subtype) | EYS | VIPR2 | GABRA1 | sigma Receptor (nonspecified subtype) | ADRB1 | BDNF-AS | MAML2 | HCRTR2 | NR3C1 | G7124 | PTTG1IP | SORCS2 | TPH2 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | KDM1A | ENOX1 | GABBR2 | CYP1A2 | GABRQ | OLFM4 | DCANP1 | POLR3B | Sodium channel (nonspecified subtype) | ANKS1B | CAMK2D | CTDSPL | COL6A1 | FAAH | CHIA | LINC02210-CRHR1 | G5743 | BTG4 | COL26A1 | CUX1 | LOC101927164 | MIR124-3 | ACSM1 | TSHR | PDE2A | SYT8 | GRM3 | IL2 | Dopamine receptor (nonspecified subtype) | PREX2 | HSD11B2 | S100A10 | CRYBA1 | TAL1 | G5243 | KCNQ1 | TPH1 | SRRM4 | FASLG | CRHR1 | SNAP25 | SLC2A1-DT | NBAS | PLEK2 | HTR6 | PAUPAR | SLC6A4 | VDR | S1PR5 | GJA1 | RO60 | GRK5 | TSNAX | GABRA5 | ADH5 | SLC2A1 | SLC6A1 | PDE5A | CHL1 | ITGB3 | IL10 | PAX8 | PDE11A | GABRD | POLA1 | AS3MT | HTR1B | TH | MIR4646 | BCKDK | SLC30A9 | 5-Hydroxytryptamine Receptor 2 (5-HT2) (nonspecified subtype) | TSPYL1 | SLC5A1 | MTHFR | FAS | HRH1 | P2RX2 | ASIC1 | NMDA receptor | TLL2 | SYNE1 | ZSWIM5 | TACR1 | PGBD1 | HTR2A | APP | NOS2 | LOC105378797 | ALKBH5 | SEMA3A | LOC105378798 | GJD2 | PHF3 | GAD1 | UTP25 | LOC105372371 | LINC01465 | CSGALNACT1 | LOC105378800 | BMP5 | NR1D1 | Gap Junction Protein (nonspecified subtype) | G7422 | ACSS3 | GMPR | RGS1 | FGF14 | P2RX7 | SDC3 | 5-Hydroxytryptamine Receptor (nonspecified subtype) | MIR659 | GGH | ABCC1 | FTO | ASTN2 | LEMD2 | ANK3 | RGS21 | GRM4 | GCSAM | IL6R | ADRA1B | HTR2C | CRY1 | CSNK1D | FRS3 | DRD3 | FRZB | NPC1 | SLC17A7 | CAVIN2 | HCG20 | KIAA0040 | RGS2 | OPCML | PDE1A | NLRP3 Inflammasome | GABRA6 | WTAP | APOE | Neuronal acetylcholine receptor alpha2beta2 receptor | MYRF | G596 | PRKCE | ANKRD27 | NEGR1 | CHRNB2 | CPM | CRHR2 | MAOB | LINC02796 | OXTR | CUX2 | GAP43 | PER3 | SLC6A3 | SLIT3 | HOTAIR | IKBKE | DENND1A | TAAR1 | SLC1A2 | NLGN1 | TMEM161B-DT | FABP2 | NVL | CHRM2 | SLC2A4 | GPR55 | MAPK8IP1 | IL18 | KCNN2 | HTR1D | IL1B | DCC | CLOCK | RUNDC3B | FADS1 | NGF | NTF3 | L3MBTL2 | GABRG1 | GAD2 | G3569 | JAK2 | TCF7L2 | GRIN2B | G114548 | KCNQ2 | HSD17B3 | SSPOP | Nicotinic alpha1beta1deltaepsilon Receptor | CAPN2 | AGBL4 | RAB27B | NTRK2 | GABRB1 | LHPP | GRIK4 | ZNF34 | PGAP2 | MAP2K5 | PDLIM5 | Phosphodiesterase (nonspecified subtype) | PCSK1 | PER2 | PTPRR | LINGO2 | GDNF | METTL3 | HTR7 | SCN2A

Note: If you'd like to get a target analysis report for Major Depression, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Major Depression at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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