Disease

Sitosterolemia

About the Disease
Sitosterolemia, also known as phytosterolemia, is related to sitosterolemia 2 and sitosterolemia 1, and has symptoms including abdominal pain An important gene associated with Sitosterolemia is ABCG5 (ATP Binding Cassette Subfamily G Member 5), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Ezetimibe and Phytosterol have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and liver, and related phenotypes are no effect and no effect

Common Targets
ZFYVE19 | NPC1L1 | TG | PCSK9 | LIPA | ABCG5 | ABCG8 | GPD1 | MEFV | APOE | LPA | ASGR1 | Asialoglycoprotein Receptor (ASGPR) (nonspecified subtype) | ELANE

疾病靶点研报
Sitosterolemia

Note: If you'd like to get a target analysis report for Sitosterolemia, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Sitosterolemia at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Congenital Fiber-type Disproportion Myopathy | Osteogenesis Imperfecta | Hypoglycemia | Hypercalciuria | Anorchia | Thin Basement Membrane Disease | Dermatofibrosarcoma | Long QT Syndrome Type 1 | Wolfram Syndrome 2 | Premenstrual Syndrome | Bipolar Disorder | Hemangioblastoma | Potocki-Shaffer Syndrome | Exfoliative Dermatitis | Depression | Heroin Dependence | Eosinophilia | Osteoglophonic Dysplasia | Bethlem Myopathy | Duchenne Muscular Dystrophy | Carpal Tunnel Syndrome | Hereditary Pyropoikilocytosis | Histiocytic Sarcoma | Hyperlipidemia, Familial Combined | Polymicrogyria | Glioma | Analgesia | Fowler's Syndrome | Juvenile Polyposis | Cerebrotendinous Xanthomatosis | Odonto-onycho-dermal Dysplasia | Metatropic Dysplasia | Granular Corneal Dystrophy Type 1 | LEOPARD Syndrome | Beare-Stevenson Syndrome | Pneumonia, Mycoplasma | Oculocutaneous Albinism Type 4 | Leukoplakia | Acute Coronary Syndrome | Plasma Cell Leukemia | Viral Meningitis | Marshall-Smith Syndrome | Noonan Syndrome | Anxiety Disorders | Rhinitis | Hyperandrogenemia | Trismus-pseudocamptodactyly Syndrome | Prolactinoma | Molybdenum Cofactor Deficiency | Charcot-Marie-Tooth Disease, Type 1A | Turner's Syndrome | Erdheim-Chester Disease | Polyneuropathy | Homocystinuria | B-cell Chronic Lymphocytic Leukemia | Tetraplegia | Cancer, Colon | Ollier Disease | Bladder Exstrophy | Hypertension, Portal | Cancer, Prostate | Macrodactyly | Mitochondrial DNA Depletion Syndrome 13 | Lattice Corneal Dystrophy | Chondrosarcoma | Spondyloarthritis | Addison Disease | Hyperkeratosis | Progressive Myoclonic Epilepsy | Ulcerative Colitis | Autism Spectrum Disorders | Peutz-Jeghers Syndrome | Adenylosuccinate Lyase Deficiency | Infantile Neuroaxonal Dystrophy | Spinocerebellar Ataxia Type 20 | Spinocerebellar Ataxia Type 8 | Kaposiform Hemangioendothelioma | Polycythemia | Ophthalmoplegia | Nance-Horan Syndrome | Uremic Pruritus | Schnyder Crystalline Corneal Dystrophy | Coronary Restenosis | Autoimmune Hemolytic Anemia | Neurodegeneration With Brain Iron Accumulation | Epidermolysis Bullosa Acquisita | Pyoderma Gangrenosum | Shock, Cardiogenic | Schizencephaly | Polycystic Kidney, Autosomal Recessive | Leishmaniasis, Cutaneous | Congenital Generalized Lipodystrophy | Fatty Aldehyde Dehydrogenase Deficiency | Glucagonoma | Hydrolethalus Syndrome | Carcinoma, Small Cell | Spinocerebellar Ataxia Type 13 | Pulmonary Veno-occlusive Disease | Atopic Dermatitis | Eosinophilic Asthma | Corticobasal Syndrome | Melanoma | Alzheimer Disease, Late Onset | Hemimegalencephaly | Diastrophic Dysplasia | Knobloch Syndrome | Acne | Familial Retinal Arterial Macroaneurysm | Panniculitis | T-cell Leukemia | Multiple Myeloma | Waardenburg Syndrome Type 4 | Sclerocornea | SAPHO Syndrome | Mixed Connective Tissue Disease | Epicondylitis | Heterotaxy | Kindler Syndrome | Dystonia | Peroxisomal Disorder | Familial Partial Lipodystrophy | Lipid Storage Diseases | Obesity | Williams Syndrome | Pseudo-pseudohypoparathyroidism | Paronychia | Encephalitis | Posterior Polar Cataract | Waardenburg Syndrome | Partington Syndrome | Imerslund-Grasbeck Syndrome | Myelitis, Transverse | Neurofibromatosis-Noonan Syndrome | Chondromyxoid Fibroma | Platelet Disorders | Mumps | Esophagitis, Eosinophilic | Early Infantile Epileptic Encephalopathy 13 | Congenital Stationary Night Blindness | Endocarditis | Congenital Lipoid Adrenal Hyperplasia | Otopalatodigital Syndrome Type 2 | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Peters-plus Syndrome | Diabetes Insipidus, Neurogenic | Alopecia | Familial Dysautonomia | Hyperferritinemia-cataract Syndrome | Diabetic Neuropathy | Androgenic Alopecia | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Meningioma, Benign | Harlequin Ichthyosis | Narcolepsy | Hypersomnia | Myoclonus-dystonia Syndrome | Amyotrophic Lateral Sclerosis | Periventricular Nodular Heterotopia | Niemann-Pick Disease, Type A | X-linked Creatine Transporter Deficiency | Portal Vein Thrombosis | Benign Familial Infantile Seizures | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Impetigo | Multiple System Atrophy | Polyomavirus Nephropathy | Antley-Bixler Syndrome | Myelomeningocele | Hypertensive Nephropathy | Encephalitis, Tick-borne | Hernia, Inguinal | McKusick Type Metaphyseal Chondrodysplasia | Thymoma, Malignant | Osteomalacia | HANAC Syndrome | Ichthyosis Hystrix, Curth-Macklin Type | Cholestasis, Intrahepatic | Scoliosis | Meningeal Melanocytoma | Hyper IgE Syndrome | Lamellar Ichthyosis | Arthritis, Gouty | Epithelioid Hemangioma | Cervical Dystonia | Fukuyama Congenital Muscular Dystrophy | Episodic Ataxia | Angioedema | Ameloblastic Carcinoma | Cataplexy | Hydrops Fetalis | Coenzyme Q10 Deficiency | Pilomatrix Carcinoma | Cardiomyopathy, Dilated, 1L | Blomstrand Osteochondrodysplasia | Greig Cephalopolysyndactyly Syndrome | Hypotrichosis Simplex | Hereditary Hemorrhagic Telangiectasia Type 2 | Myotonic Disorders | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Scleroderma, Diffuse | WAGR Syndrome | Cleidocranial Dysplasia | Aromatic L-amino Acid Decarboxylase Deficiency | Canavan Disease | Cheilitis | Cyclic Vomiting Syndrome | Mucolipidosis | Meningioma | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Hypertrophy | Chondroma | Larsen Syndrome | Lymphomatoid Granulomatosis | Jaundice, Obstructive | Papillorenal Syndrome | Familial Cerebral Amyloid Angiopathy | Heimler Syndrome | Bartter Syndrome | Clouston Hidrotic Ectodermal Dysplasia | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Cyst | Craniopharyngioma | Epilepsy | Primary Lateral Sclerosis | ADNP Syndrome | Spinocerebellar Ataxia Type 6 | Maternally Inherited Diabetes And Deafness | Fibrosarcoma | Duodenal Atresia | Aneurysm, Thoracic Aortic | Muckle-Wells Syndrome | Intracranial Hypertension | Tumoral Calcinosis | Methemoglobinemia Type IV | Leri-Weill Dyschondrosteosis | Toxic Epidermal Necrolysis | Sarcoma | Microphthalmia | Dystonia-parkinsonism, X-linked | Alkaptonuria | Zellweger Syndrome | Transthyretin-related Amyloidosis | Generalized Epilepsy And Paroxysmal Dyskinesia | Headache | Pelizaeus-Merzbacher Disease | Vitreoretinal Degeneration, Snowflake Type | Erectile Dysfunction | Primary Progressive Aphasia | Nephritis, Interstitial | Thyroid Hormone Resistance | Hypohidrotic Ectodermal Dysplasia | Lymphoma, Mantle Cell | Liver Failure | Hidradenitis Suppurativa | Japanese Encephalitis | Fibromyalgia | Neural Tube Defect | Sclerosing Cholangitis | Inflammatory Linear Verrucous Epidermal Nevus | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Chronic Beryllium Disease | Osteogenesis Imperfecta Type IV | Lassa Fever | Charcot-Marie-Tooth Disease Type 2D | Arthritis, Reactive | Subacute Sclerosing Panencephalitis | Triphalangeal Thumb-polysyndactyly Syndrome | Camptocormia | Synpolydactyly | Early Infantile Epileptic Encephalopathy 4 | Dermatitis | Amish Infantile Epilepsy Syndrome | Kaposi Sarcoma | Microphthalmia, Syndromic 7 | C3 Glomerulopathy | Osteomyelitis | Conjunctivitis, Allergic | Enlarged Vestibular Aqueduct | Feingold Syndrome | Asphyxia Neonatorum | Sensory Neuropathy | Chorioretinitis | Polyarteritis Nodosa | Familial Hyperaldosteronism | Riboflavin Transporter Deficiency Neuronopathy | Hypersensitivity | Lipid Metabolism Disorders | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Hereditary Folate Malabsorption | Blastomycosis | Meningococcal Infections | Urea Cycle Disorder | Hemangioendothelioma | Pulmonary Capillary Hemangiomatosis | Blue Rubber Bleb Nevus Syndrome | Superficial Spreading Melanoma | Idiopathic Pulmonary Fibrosis | Omenn Syndrome | Allergic Contact Dermatitis | Renal Hypouricemia | Shwachman-Bodian-Diamond Syndrome | Leprosy | Interstitial Lung Diseases | Hypermetropia | Familial Thoracic Aortic Aneurysm | Dyslexia | Fahr Disease | Charcot-Marie-Tooth Disease Type 4E | Epidermolysis Bullosa Dystrophica | Dubin-Johnson Syndrome | Geleophysic Dysplasia | Neurogenic Bladder | Osteoarthritis | Gallstones | Central Core Disease | Goiter, Nodular | Enterocolitis, Necrotizing | Growth Hormone Excess | Cardiomyopathy, Restrictive | Urethritis | Behavioral Variant Of Frontotemporal Dementia | Congenital Mirror Movements | Spinocerebellar Ataxia Type 16 | Acral Lentiginous Melanoma | Colitis, Microscopic | Pulmonary Alveolar Proteinosis | Beckwith-Wiedemann Syndrome | Charcot-Marie-Tooth Disease Type 3 | Donnai-Barrow Syndrome | Cerebellar Ataxia, Cayman Type | 3-methylglutaconic Aciduria Type I | AIDS Dementia Complex | Sarcomatoid Carcinoma Of The Lung | Delayed Sleep Phase Syndrome | Niemann-Pick Disease | Antithrombin III Deficiency | Cardiomyopathy, Peripartum | Progressive External Ophthalmoplegia | Blepharophimosis Syndrome | Paternal Uniparental Disomy Of Chromosome 14 | Osteosarcoma | Trichotillomania | Spinocerebellar Ataxia Type 2 | Aneurysm, Abdominal Aortic | Polycystic Ovary Syndrome | Sporadic Inclusion Body Myositis | Progressive Osseous Heteroplasia | Autosomal Recessive Spastic Paraplegia Type 35 | Sorsby Fundus Dystrophy | Macular Corneal Dystrophy | Galactosialidosis | Liver Failure, Acute Infantile | Retinitis | Neurofibromatosis Type 2 | Holoprosencephaly | Nestor-Guillermo Progeria Syndrome | Cornelia De Lange Syndrome | Conjunctivitis | Atrial Septal Defect | Pernicious Anemia | Tardive Dyskinesia | Blastoma, Pleuropulmonary | Chloridorrhea, Congenital | Brooke-Spiegler Syndrome | Protein C Deficiency | Vasculitis | Fanconi Anemia | Ebstein Anomaly | Lathosterolosis | Von Hippel-Lindau Disease | Poirier-Bienvenu Neurodevelopmental Syndrome | Basal Cell Nevus Syndrome | Alopecia Totalis | Hereditary Mixed Polyposis Syndrome | Tendinitis | Angiomyolipoma | Erythromelalgia | Lentigo | Pneumonia, Bacterial | Hypophosphatasia | Esophagitis | Sialidosis | Reye Syndrome | Mabry Syndrome | Thyroid Dyshormonogenesis | T-cell Chronic Lymphocytic Leukemia | Gingivitis | Tay-Sachs Disease | Vitamin A Deficiency | Chondrodysplasia Punctata 2, X-linked Dominant | Inflammatory Myofibroblastic Tumor | HELLP Syndrome | Choroiditis | Synovitis | Waardenburg Syndrome Type 2E | Charcot-Marie-Tooth Disease Type 4B1 | Bainbridge-Ropers Syndrome | Epidermolysis Bullosa | Primary Pigmented Nodular Adrenocortical Disease | Tatton-Brown-Rahman Syndrome