Disease

Osteoporosis

About the Disease
Bone Mineral Density Quantitative Trait Locus 8, also known as osteoporosis, is related to osteoporosis and bone mineral density quantitative trait locus 15, and has symptoms including angina pectoris, back pain and muscle cramp. An important gene associated with Bone Mineral Density Quantitative Trait Locus 8 is BMND8 (Bone Mineral Density Quantiative Trait Locus 8). The drugs Clobetasol and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spinal cord.

Common Targets
MAOB | VHL | CDK19 | GLP1R | PTGER2 | G5743 | IFNG | SERPINF1 | Monoamine oxidase (MAO) (nonspecified subtype) | GCGR | PIM2 | FLT3 | GSK3A | DCAF13 | NCOR1 | RHOJ | G5347 | PER2 | NADPH Oxidase (nonspecified subtype) | MATN3 | HROB | MTHFR | CYP19A1 | MIR149 | MMP1 | SLC5A2 | YES1 | CAPZB | GPR55 | MST1R | TNKS | COLEC10 | SPP1 | GDF11 | G7422 | FGR | ALPL | HCK | TNFRSF11B | RUNX2 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | LRP6 | HSD17B2 | FFAR4 | Proteasome Complex | GPR119 | G5243 | SDC1 | DPYD | JAK3 | TACR3 | MPO | CCN1 | G6714 | NTRK2 | PKD1 | ZBTB4 | GAPDH | AURKA | Protein farnesyltransferase | JAK1 | THSD4 | Integrin alpha4beta1 (VLA-4) receptor | Calpain (nonspecified subtype) | CRY2 | G3845 | RAC1 | RORC | GRIN2C | PREP | F2RL1 | RYR1 | Interleukin 17 (nonspecified subtype) | ABL1 | DNA-Directed DNA Polymerase Complex | CRBN | CTSF | CHKA | KDR | gamma-Secretase | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | TNFRSF1B | WNT11 | UGT1A8 | G1956 | FFAR1 | HFE | G3576 | L-type voltage-dependent calcium channel complex | Geranylgeranyl transferase type-1 | CDKL5 | GHSR | Carbonic Anhydrase (nonspecified subtype) | THRB | PNRC2 | SPHK2 | SOST | SEC24D | PTPRE | AKR1C2 | ARRB2 | SMO | Tyrosine-Protein Kinases Src (nonspecified subtype) | JAK2 | FNDC5 | ABHD12 | TRPV4 | COL1A1 | Interleukin-1 (nonspecified subtype) | FDFT1 | IKBKB | CSK | Thyroid hormone receptor (nonspecified subtype) | CNOT7 | FGFR2 | LRRK1 | C-X-C Chemokine Receptor CXCR1/CXCR2 (IL-8 Receptor) (nonspecified subtype) | MIR139 | CA6 | VKORC1 | FSHR | G7124 | Acid-Sensing Ion Channel (ASIC) (nonspecified subtype) | PDE4B | PITHD1 | LPAR1 | P2RY4 | BMP2 | AMP-activated protein kinase (AMPK) | ARHGDIA | Steroid 5-alpha-Reductase (nonspecified subtype) | Integrin alphavbeta3 (vitronectin) receptor | Phospholipase A2 (nonspecified subtype) | MAGEB2 | CTSS | CLEC14A | PLS3 | Hedgehog Protein (nonspecified subtype) | PDE1C | SMAD6 | CA1 | BTK | Casein kinase I (nonspecified subtype) | PHB1 | HIF1A | ADAMTS5 | ROCK1 | Heat shock protein 90 (nonspecified subtype) | Phosphodiesterase IV (PDE4) (nonspecified subtype) | G6774 | NAPEPLD | CA12 | IKBKG | MC2R | CTSL | GRIN2D | CNMD | PTK6 | MMP3 | AXL | SHBG | KHK | BMX | ACE | LRP5 | LOC102724428 | SAT2 | Protein Kinase B (PKB/Akt) (nonspecified subtype) | ARRB1 | KCNK2 | GH1 | PIM3 | ALDH2 | G842 | CASR | MIR34B | ATP2A1 | Calcium channel (nonspecified subtype) | LCK | LTA | PPARA | Integrin Receptor (nonspecified subtype) | BMP1 | S1PR2 | G1432 | CNR2 | IL1B | TGFB1 | Lipoxygenase (nonspecified subtype) | Matrix Metalloproteinase (MMP) (nonspecified subtype) | Calcium-Activated K(Ca) Potassium Channel (nonspecified subtype) | ENG | TYR | MAP3K14 | PLVAP | CSF1R | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | PIEZO1 | NPY2R | TNFSF11 | Gap junction Connexin ( (nonspecified subtype) | Protein kinase C (nonspecified subtype) | IAPP | ADORA2B | SFRP4 | TOP1 | KEAP1 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | Oxysterols receptor LXR (nonspecified subtype) | G5133 | G3569 | Adenylate Cyclase (nonspecified subtype) | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | TYK2 | HPGD | IL-20 receptor | Chloride channel (nonspecified subtype) | Raf kinase (nonspecified subtype) | ESR2 | GLO1 | ADORA1 | PCSK9 | Amylin receptor | TRPM8 | KIT | HMGCR | MIR335 | DKK1 | CXXC5 | PGAM5-KEAP1-NRF2 Complex | Arrestin (nonspecified subtype) | G23411 | Neurotrophic Tyrosine Kinase Receptor (TRK) (nonspecified subtype) | G4780 | DOCK5 | ACP5 | MTNR1B | POLL | GPX1 | DYRK3 | GIPR | ZNF267 | MIR21 | FUCA1 | Integrin alphaIIbbeta3 (fibrinogen gpIIb/IIIa) receptor | PGR | SMURF1 | MIR34C | ICAM1 | BRD4 | BCHE | NF-kappaB (NFkB) | DYRK1A | Casein kinase II (CKII) | INSR | Integrin alphavbeta5 receptor | DNA Topoisomerase II (nonspecified subtype) | TNKS2 | CYP24A1 | GABA(A) receptor | Estrogen receptor (nonspecified subtype) | SOX5 | NTRK3 | ADGRV1 | ABCC2 | CCR2 | CNR1 | HSD11B1 | INHBA | LCT | MEGF6 | P4HB | ZNF239 | PPARD | STAT5 (nonspecified subtype) | RORA | XYLT2 | AXIN1 | Bone Morphogenetic Protein Receptor (nonspecified subtype) | IL-6 receptor | PTK2B | COL1A2 | RPL11 | DNAH2 | DPP4 | MMP7 | PTCH1 | WWTR1 | Tyrosine Kinase (nonspecified subtype) | Cysteine Protease (nonspecified subtype) | COL10A1 | G142 | PDGFRB | TGFBR1 | MEN1 | ATP2A2 | ESRRA | AKR1B1 | TPH2 | ADORA2A | SPTBN1 | ACVRL1 | Voltage-Gated Sodium Channel Complex | SYK | CASP8 | FTCDNL1 | G3605 | F2 | HCRTR2 | ADORA3 | 17-beta-Hydroxysteroid dehydrogenase (nonspecified subtype) | GPR183 | GPR84 | CBS | Glycylpeptide N-tetradecanoyltransferase (nonspecified subtype) | FDPS | PTH | XDH | TCIRG1 | Vacuolar H+ ATPase | ACVR1B | MERTK | RPP21 | LINC02075 | STS | NTRK1 | TNFRSF11A | GSK3B | PTGER4 | PTGS1 | PTPN1 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | KMT2A | GHR | MIR214 | G9429 | NR1H4 | SGMS2 | ACHE | TSHR | MLL/SET1 Complex | PPARG | CRTAP | Leukotriene B4 receptor (LTB4-R) (nonspecified subtype) | RXRA | Cytochrome P450 Enzymes (nonspecified subtype) | HSD11B2 | NBAS | PTPN4 | KDM6B | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | TYRO3 | POLR2A | ABCC8 | MMP13 | PER1 | SP7 | MSTN | ADAMTS4 | TPH1 | G2475 | GCA | FAAH | ZIC2 | MIR29A | Caspase (nonspecified subtype) | CA14 | S1PR5 | PDE2A | G2099 | L-Type calcium channel (nonspecified subtype) | GJA1 | G3630 | Integrin alphavbeta6 receptor | Sodium channel (nonspecified subtype) | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 (nonspecified protein) | Cannabinoid receptor (nonspecified subtype) | LGR4 | Adenosine receptor (nonspecified subtype) | CSF2RA | SLC10A2 | FASN | SIK2 | G836 | PTH1R | Poly [ADP-ribose] polymerase (nonspecified subtype) | CPED1 | PIM1 | DYRK1B | Mitogen-Activated Protein Kinase (nonspecified subtype) | DDR1 | FPR2 | CDK8 | GLP2R | Janus Kinase (nonspecified subtype) | TEK | ABLIM2 | CTSK | ASIC1 | PLXNB1 | Gastric H+/K+-ATPase | CA9 | PCDHB7 | SLC5A1 | AP-1 Transcription Factor Complex | PLAU | MMP8 | WNT16 | Neurotensin receptor (nonspecified subtype) | CA2 | HSD17B1 | G196 | G4318 | WNT1 | NMT1 | SNHG12 | ERBB4 | SATB2 | IL20 | SIGLEC15 | METAP2 | HIVEP3 | Angiotensin receptor (AT) (nonspecified subtype) | Gap Junction Protein (nonspecified subtype) | CCR4-NOT transcription complex | Cyclooxygenase (COX) (nonspecified subtype) | ADRB2 | C5AR1 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | TIGIT | GHRHR | Integrin alphavbeta1 | G7157 | alpha1-Adrenoceptor (nonspecified subtype) | SIK1 | IL1R2 | NR4A2 | COL27A1 | ALDH7A1 | ROCK2 | Endothelin receptor (nonspecified subtype) | LYN | SLC6A4 | CRY1 | GAA | HCAR2 | Calcium/calmodulin-dependent protein kinase type II (CaMK-II) | NOX3 | SFRP1 | CTSB | ZNF384 | AGTR2 | CALCR | COL21A1 | PDE5A | DYRK2 | Retinoid RXR receptor (nonspecified subtype) | CASP1 | Parathyroid Hormone Receptors (PTHR) (nonspecified subtype) | IL2 | MIR146A | G3146 | USP7 | NAMPT | Integrin alphavbeta8 Receptor | MMP10 | AGER | HMGB2 | Nitric oxide synthase (NOS) (nonspecified subtype) | Collagenase (nonspecified subtype) | NR3C1 | MMP14 | MMP2 | FSHB | LINC01877 | G367 | G4233 | CD68 | ADAMTS1 | PTGFR | THSD7A | PER3 | CCL2 | CYP11B2 | NADPH Oxidase Complex | TXK | FYN | HTR2A | CLCN7 | MIR196A2 | TNFRSF1A | PTPN11 | Tubulin | G2064 | SIK3 | CLOCK | TRPA1 | TGIF2 | NOTUM | Rho kinase (ROCK) (nonspecified subtype) | P2RX7 | LEKR1 | VDR | NOS2 | IFT172 | HSD17B3 | MIF | MIR499A | ALOX5 | MAP2K5 | RET | OSCAR | S1PR1 | Soluble guanylyl cyclase | INPP5D | BMPR2 | FGF2 | PDGFRA

疾病靶点研报
Osteoporosis

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