Hypotrichosis Simplex

About the Disease
Hypotrichosis Simplex, also known as hereditary hypotrichosis simplex, is related to hypotrichosis 1 and hypotrichosis 3. An important gene associated with Hypotrichosis Simplex is APCDD1 (APC Down-Regulated 1), and among its related pathways/superpathways are WNT Signaling and Canonical Wnt Pathway. The drugs Anti-Infective Agents and Gentamicins have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are alopecia and sparse body hair

Common Targets
CENPU | FRG1-DT | SORBS2 | DSG4 | CYP4V2 | SNRPE | F11-AS1 | ANKRD37 | DSP | RPL21 | LSS | LPAR6 | HR | F11 | CDH3 | PTGER1 | ENPP6 | LIPH | ZC3H3 | PRIMPOL

Note: If you'd like to get a target analysis report for Hypotrichosis Simplex, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Hypotrichosis Simplex at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Chylomicron Retention Disease | Albinism | Triple A Syndrome | Gliosarcoma | Sjogren Syndrome | Colon Adenoma | Epilepsy, Generalized | Ovarian Hyperstimulation Syndrome | Lattice Corneal Dystrophy Type 1 | Acute Anterior Uveitis | Acquired Partial Lipodystrophy | Alpha-thalassemia Myelodysplasia Syndrome | Transcobalamin Deficiency | Sepiapterin Reductase Deficiency | LRBA Deficiency | Retinopathy Of Prematurity | Pityriasis Rubra Pilaris | Guillain-Barre Syndrome | Spinocerebellar Ataxia Type 7 | Glomerulonephritis, Membranous | Infantile Liver Failure Syndrome 1 | Infantile Neuroaxonal Dystrophy | Melanoma, Uveal | Pontocerebellar Hypoplasia Type 7 | Coronary Heart Disease | Retinal Detachment | Trichomegaly | Keratoacanthoma | Galloway-Mowat Syndrome | Chondrodysplasia Punctata 1, X-linked Recessive | Fascioliasis | WAGR Syndrome | Spina Bifida | Varices | Glycogen Storage Disease Type 6 | Craniometaphyseal Dysplasia | Anterior Segment Dysgenesis | Infantile Spasm | Antisocial Personality Disorder | Arthritis, Psoriatic | Hypercalciuria | Colitis, Microscopic | Impetigo | Yellow Fever | Inflammatory Joint Disease | Osteochondroma | Hypotension, Orthostatic | Diabetes Type 1 | Tinea Versicolor | Spinal Muscular Atrophy Type 3 | Hypogonadism | Usher Syndrome Type III | Carcinoid Tumor | Infantile Nephropathic Cystinosis | Metabolic Diseases | Thymoma, Malignant | Antenatal Bartter Syndrome Type 1 | Epidermolysis Bullosa Simplex, Localized | Congenital Nystagmus | Cholesteryl Ester Storage Disease | Granular Corneal Dystrophy Type 1 | Miyoshi Myopathy | Parkinsonism | Vitamin K Deficiency | Eclampsia | Anorectal Fistula | Early Infantile Epileptic Encephalopathy 28 | ADNP Syndrome | Stevens-Johnson Syndrome | Periodic Limb Movement Disorder | Van Der Knaap Disease | Pierre Robin Syndrome | Blepharospasm | Takotsubo Cardiomyopathy | Tay-Sachs Disease | Autosomal Recessive Congenital Ichthyosis | Familial Partial Lipodystrophy | Hidradenitis Suppurativa | Gilbert Syndrome | Cramp Fasciculation Syndrome | Orotic Aciduria | Goiter | Pyruvate Decarboxylase Deficiency | Hypersomnia | Glycogen Storage Disease Type 0 | Duchenne Muscular Dystrophy | Hepatopulmonary Syndrome | Proteus Syndrome | Autoimmune Autonomic Ganglionopathy | Hyperandrogenemia | Veno-occlusive Disease | Pilomatrix Carcinoma | Stroke, Ischemic | Granular Corneal Dystrophy | Myotonic Disorders | Pseudoachondroplasia | Sotos Syndrome | Shprintzen-Goldberg Syndrome | Hyperthyroidism | Choriocarcinoma | Barrett Esophagus | Membranous Nephropathy | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Fibromuscular Dysplasia | Esotropia | Craniopharyngioma | Atelosteogenesis Type 1 | Paraplegia | Cardiac Arrest | Neutrophilia | Spinal Muscular Atrophy | Combined Malonic And Methylmalonic Acidemia | Epidermolysis Bullosa Acquisita | Charcot-Marie-Tooth Disease Type 4B1 | Isobutyryl-CoA Dehydrogenase Deficiency | Pseudohypoparathyroidism Type 1A | Liver Failure | Pancytopenia | Bronchitis, Chronic | Nager Acrofacial Dysostosis | Parvovirus B19 Infection | Acrodysostosis | Retinitis | Osteomalacia | Trichuriasis | Nail Disorder, Nonsyndromic Congenital | N-acetylglutamate Synthase Deficiency | Mood Disorder | Acne Vulgaris | X-linked Myotubular Myopathy | Cystinuria | Encephalopathy, Ethylmalonic | Congenital Tufting Enteropathy | Milk Allergy | Homocystinuria | Congenital Disorders Of Glycosylation Type II | Brugada Syndrome 1 | Meconium Ileus | Benign Familial Infantile Seizures | Lymphoma, Mantle Cell | Gerstmann-Straussler-Scheinker Syndrome | Small Lymphocytic Lymphoma | Persistent Truncus Arteriosus | Hyperlipidemia, Familial Combined | Spinocerebellar Ataxia Type 12 | Antisynthetase Syndrome | Wilson's Disease | Cystitis | Lymphangiomatosis | Proctitis | Multiple Epiphyseal Dysplasia | Ichthyosis Bullosa Of Siemens | Idiopathic Multicentric Castleman Disease | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Endometrial Hyperplasia | Tyrosine Hydroxylase Deficiency | Aspartylglycosaminuria | Joubert Syndrome 2 | Myocardial Infarction | Spinocerebellar Ataxia Type 20 | Chromosome 8q21.11 Deletion Syndrome | Hyperkeratosis | Hemorrhage | Carbamoyl Phosphate Synthetase I Deficiency | Occipital Neuralgia | Nephrotic Syndrome Type 1 | Microcephaly | Ureteropelvic Junction Obstruction | Familial Hemiplegic Migraine | Fibrillation, Atrial | Epidermolysis Bullosa Simplex | Toxic Epidermal Necrolysis | Glycogen Storage Disease Type 1a | Gingivitis | Mitochondrial DNA Depletion Syndrome | Glaucoma, Congenital | Dengue Shock Syndrome | Rash | T-cell Lymphoma, Subcutaneous Panniculitis-like | Leukocyte Adhesion Deficiency | Metachromatic Leukodystrophy | Melanocytic Nevus | Autosomal Recessive Bestrophinopathy | Glaucomatocyclitic Crisis | Diffuse Intrinsic Pontine Glioma | Rotor Syndrome | Leiomyoma | Hydrocephalus, Normal Pressure | Primary Progressive Aphasia | Campomelic Dysplasia | Schamberg Disease | Autoimmune Hemolytic Anemia | Meniere's Disease | Aldosteronism | Gastric Atrophy | Multiple Sulfatase Deficiency | Cardiofaciocutaneous Syndrome | Cysticercosis | Retinitis Pigmentosa 3 | Metabolic Syndrome | Osteoporosis, Postmenopausal | Congenital Dyserythropoietic Anemia Type 4 | Gray Platelet Syndrome | Neurofibroma | Zellweger Syndrome | Myocarditis | Angina Pectoris | Usher Syndrome Type IIC | Panuveitis | Arthritis, Gouty | Hereditary Pyropoikilocytosis | Diabetic Macular Edema | Myotonia | Pulmonary Alveolar Proteinosis | Renal Tubular Dysgenesis | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Acute Generalized Exanthematous Pustulosis | Long QT Syndrome Type 1 | Systemic Mastocytosis | Lymphedema-distichiasis Syndrome | H Syndrome | Harlequin Ichthyosis | Ulcerative Colitis | Oligospermia | Neuropathy | Pleurisy | Rosacea | Neurofibromatosis-Noonan Syndrome | Primary Hyperoxaluria Type 3 | DOCK8 Immunodeficiency Syndrome | Mosaic Variegated Aneuploidy Syndrome 2 | Sick Sinus Syndrome | Autosomal Recessive Spastic Paraplegia Type 75 | Turner's Syndrome | Diabetes Mellitus, Transient Neonatal | Teratozoospermia | Tendinopathy | Dominant Optic Atrophy | Cutaneous Lupus Erythematosus | Carcinoma, Signet Ring Cell | Chronic Beryllium Disease | Hyperparathyroidism, Secondary | Schwannomatosis | Guanidinoacetate Methyltransferase Deficiency | Menkes Disease | Viral Meningitis | Smith-Lemli-Opitz Syndrome | Hernia, Inguinal | C3 Glomerulopathy | Hypopituitarism | Globozoospermia | Trimethylaminuria | Brooke-Spiegler Syndrome | Methylmalonic Acidemia | Carpal Tunnel Syndrome | Hypodontia | Glycogen Storage Disease | Paraganglioma, Carotid Body | Leukoencephalopathy, Progressive Multifocal | Restless Legs Syndrome | Blepharo-cheilo-odontic Syndrome | Hyperammonemia | Erectile Dysfunction | Gitelman Syndrome | Ganglioglioma | Neuroleptic Malignant Syndrome | Chronic Granulomatous Disease, X-linked | Thalassemia | Primary Progressive Nonfluent Aphasia | Mitochondrial Disease | Premenstrual Syndrome | Pulmonary Tuberculosis | Wiskott-Aldrich Syndrome | Cancer, Skin | Blastoma, Pleuropulmonary | Cutaneous Angiosarcoma | Protein C Deficiency | Acne | Eczema | Congenital Absence Of Vas Deferens | Mucolipidosis Type IV | Liddle Syndrome | McLeod Syndrome | Central Retinal Artery Occlusion | Primary Torsion Dystonia | Hypercalcemia | Pseudohypoaldosteronism | Duodenal Atresia | Rheumatoid Arthritis | Spinocerebellar Ataxia | Aicardi-Goutieres Syndrome | Dentinogenesis Imperfecta | Still Disease | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | X-linked Creatine Transporter Deficiency | Adenocarcinoma | Frontotemporal Dementia | Ophthalmia, Sympathetic | Neurofibrosarcoma | Hereditary Multiple Exostoses | Inflammatory Myofibroblastic Tumor | Branchiootorenal Syndrome | Sensory Neuropathy | Cholestasis | Tonsillitis | Hereditary Coproporphyria | Huntington's Disease | Tic Disorder | Hemolytic Uremic Syndrome | CHARGE Syndrome | Cold-induced Sweating Syndrome | Muscular Dystrophy | Bietti Crystalline Dystrophy | Hyperuricemic Nephropathy, Familial Juvenile | Progressive Familial Intrahepatic Cholestasis | Oculocutaneous Albinism Type 1 | Cranial Nerve Disease | Beare-Stevenson Syndrome | Angioedema, Acquired | Behavioral Variant Of Frontotemporal Dementia | Peyronie's Disease | Hypophosphatasia | Congenital Torticollis | Bipolar Disorder | Kabuki Syndrome | Pseudohypoparathyroidism Type 2 | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Empyema | Schizophrenia | Chronic Neutrophilic Leukemia | Primary Carnitine Deficiency | Kabuki Syndrome 2 | Trismus-pseudocamptodactyly Syndrome | 3-methylcrotonyl-CoA Carboxylase Deficiency | Adenoma, Pituitary | Low Tension Glaucoma | Paget's Disease Of The Breast | POEMS Syndrome | Rift Valley Fever | Charcot-Marie-Tooth Disease Axonal Type 2N | Chronic Granulomatous Disease | Lung Diseases | Ellis-Van Creveld Syndrome | Optic Atrophy 2 | Hemolytic Uremic Syndrome, Atypical | Cellulitis | Coronary Artery Disease | Vascular Calcification | Methemoglobinemia | Pseudomyxoma Peritonei | Zollinger-Ellison Syndrome | Chondrodysplasia Punctata 2, X-linked Dominant | Dermatitis Herpetiformis | Hairy Cell Leukemia | Smoldering Myeloma | Amyotrophic Lateral Sclerosis, Juvenile | Epithelioid Hemangioma | Carney Triad | Diastrophic Dysplasia | Genitopatellar Syndrome | Retinoschisis | Charcot-Marie-Tooth Disease Type 4 | Tremor | NDH Syndrome | Vestibular Disease | Rhabdomyosarcoma | Infectious Diarrhea | Idiopathic Pulmonary Fibrosis | Spondylocarpotarsal Synostosis Syndrome | Non-Hodgkin Lymphoma | Asthma, Exercise-induced | Necrobiosis Lipoidica | Tuberculous Meningitis | Sezary Syndrome | Open-angle Glaucoma | Lymphedema | Adenomyosis | Tangier Disease | Ichthyosis Hystrix, Curth-Macklin Type | Epicondylitis | Congenital Afibrinogenemia | Neurodegeneration With Brain Iron Accumulation | Spinocerebellar Ataxia Type 23 | Pre-eclampsia | Molybdenum Cofactor Deficiency | Adrenal Insufficiency | Congenital Myopathy | Glucagonoma | Hypopigmentation | Walker-Warburg Syndrome | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Hepatic Veno-occlusive Disease | Chronic Myeloid Leukemia | Carotid Artery Disease | Polyneuropathy | Stomatitis | Congenital Hypofibrinogenemia | Aldosterone Synthase Deficiency | Birk-Barel Syndrome | Castleman Disease