Disease

Pseudohypoparathyroidism Type 1A

About the Disease
Pseudohypoparathyroidism, Type Ia, also known as albright's hereditary osteodystrophy, is related to hyperphosphatemia and congenital hypothyroidism, and has symptoms including seizures An important gene associated with Pseudohypoparathyroidism, Type Ia is GNAS (GNAS Complex Locus), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Theophylline and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and thyroid, and related phenotypes are pseudohypoparathyroidism and precocious puberty

Common Targets
GNAS

疾病靶点研报
Pseudohypoparathyroidism Type 1A

Note: If you'd like to get a target analysis report for Pseudohypoparathyroidism Type 1A, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Pseudohypoparathyroidism Type 1A at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Adenoma, Pituitary | Hepatitis B, Chronic | Cyst | Tietze Syndrome | Varicocele | Sclerosteosis 2 | Pernicious Anemia | Congenital Heart Block | Glycogen Storage Disease | Marshall-Smith Syndrome | Proximal Symphalangism | Kawasaki Disease | Mycosis Fungoides | Hyperlipidemia | Acquired Partial Lipodystrophy | H Syndrome | Double Outlet Right Ventricle | Pseudo-pseudohypoparathyroidism | Wolff-Parkinson-White Syndrome | Multifocal Motor Neuropathy | Alpha-mannosidosis | Cabezas Syndrome | Exotropia | Constipation | Cenani-Lenz Syndactyly Syndrome | Hereditary Elliptocytosis | Hypokalemia | Disseminated Superficial Actinic Porokeratosis | Hidradenitis | Transthyretin-related Amyloidosis | Keratosis | Tuberculosis | Epidermolysis Bullosa Simplex, Localized | Glycogen Storage Disease Type 1 | Creatine Deficiency Syndrome Due To AGAT Deficiency | Macrophage Activation Syndrome | Long QT Syndrome Type 3 | Primary Torsion Dystonia | Diabetes Type 2 | Myotonic Disorders | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Generalized Epilepsy With Febrile Seizures Plus | Neurofibromatosis-Noonan Syndrome | Retinal Dystrophy | Spinocerebellar Ataxia Type 20 | Leprosy | Measles | Harlequin Ichthyosis | Pigment Dispersion Syndrome | Proopiomelanocortin Deficiency | Cyclic Vomiting Syndrome | Chronic Beryllium Disease | Nasodigitoacoustic Syndrome | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Optic Neuropathy, Anterior Ischemic | Corticobasal Syndrome | Peeling Skin Syndrome, Acral Type | Gigantism | Chronic Idiopathic Myelofibrosis | Myofibromatosis | Galactosialidosis | Wolfram Syndrome 2 | Nanophthalmos | CEDNIK Syndrome | Duodenal Atresia | Medium-chain Acyl-CoA Dehydrogenase Deficiency | B-cell Chronic Lymphocytic Leukemia | Skin Papilloma | Progressive Myoclonic Epilepsy | Microtia | Agammaglobulinemia | ICF Syndrome | Atelosteogenesis Type 2 | Neuromyotonia | Sickle Cell Anemia | Lymphoproliferative Disease, X-linked | Craniopharyngioma | Combined Malonic And Methylmalonic Acidemia | Strabismus | Amenorrhea | Renal Medullary Carcinoma | Hidradenitis Suppurativa | Proteus Syndrome | Blood Protein Disorders | Fanconi Syndrome | Chronic Enteropathy Associated With SLCO2A1 Gene | Chronic Leukemia | Chanarin-Dorfman Syndrome | Transient Bullous Dermolysis Of The Newborn | Pyelonephritis | Vogt-Koyanagi-Harada Syndrome | Yellow Fever | Bardet-Biedl Syndrome | Tic Disorder | Cat Eye Syndrome | Neonatal Progeroid Syndrome | Gastric Atrophy | Ventricular Septal Defect | Stuttering | Erythromelalgia | Epicondylitis | Spondylosis | Non-Hodgkin Lymphoma | Metachromatic Leukodystrophy | Phosphoglycerate Dehydrogenase Deficiency | Bacterial Meningitis | Ganglioglioma | Albinism | Macrodactyly | Encephalitis | GATA2 Deficiency | Galactosemia | Usher Syndrome Type I | Angioedema, Acquired | Poikiloderma With Neutropenia | Marfan Syndrome | Spondyloepiphyseal Dysplasia Tarda, X-linked | Echinococcosis | Retinopathy Of Prematurity | Trachoma | Porphyria | Lymphoma, B-cell | Behcet's Disease | Giant Axonal Neuropathy | Chondrosarcoma | Brachial Plexus Neuropathy | Bruck Syndrome | Dermatitis | Hypotonia-cystinuria Syndrome | Osteopetrosis | Stickler Syndrome | Specific Granule Deficiency | Myofibrillar Myopathy | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | ACTH-independent Macronodular Adrenal Hyperplasia | Trichorhinophalangeal Syndrome | Hepatopulmonary Syndrome | Hypolipoproteinemia | Ghosal Syndrome | Allan-Herndon-Dudley Syndrome | Thanatophoric Dysplasia | Liver Diseases | Thalassemia | Histiocytic Sarcoma | Sporadic Inclusion Body Myositis | Snyder-Robinson Syndrome | Mitochondrial Myopathy | Diabetes Gestational | Congenital Generalized Lipodystrophy | Peeling Skin Syndrome Type B | Sensorineural Hearing Loss | Moyamoya Disease | Hereditary Coproporphyria | Pulmonary Alveolar Proteinosis | Malignant Peripheral Nerve Sheath Tumor | Lassa Fever | Asphyxia Neonatorum | Non-Langerhans Cell Histiocytosis | Triple A Syndrome | Antisocial Personality Disorder | Congenital Ichthyosiform Erythroderma | Scapuloperoneal Myopathy, X-linked Dominant | Riboflavin Transporter Deficiency Neuronopathy | Diabetes Mellitus, Transient Neonatal | Lattice Corneal Dystrophy | Retinitis Pigmentosa | Nevus | Schistosomiasis Mansoni | Periventricular Nodular Heterotopia | Microphthalmia, Syndromic 7 | Hypertension, Renovascular | Birk-Barel Syndrome | Bronchitis, Chronic | Epilepsy, Generalized | Granular Corneal Dystrophy | 3-methylglutaconic Aciduria Type I | Progressive Familial Intrahepatic Cholestasis Type 3 | Astrocytoma | Sarcoma, Alveolar Soft Part | Cutaneous Angiosarcoma | Primary Progressive Aphasia | Mohr-Tranebjaerg Syndrome | Hypogammaglobulinemia | Seizures-scoliosis-macrocephaly Syndrome | Tatton-Brown-Rahman Syndrome | Spinocerebellar Ataxia Type 10 | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Fontaine Progeroid Syndrome | Gangliosidosis, GM1 | Enterocolitis, Necrotizing | Spasticity | Oligodendroglioma | Fraser Syndrome | Acne Vulgaris | Spermatocele | Fuchs Heterochromic Iridocyclitis | Hypervalinemia | Avian Influenza | Glutaric Aciduria Type 1 | Acrodermatitis Enteropathica | Stiff-man Syndrome | Bernard-Soulier Syndrome | Acute Tubular Necrosis | Chronic Thromboembolic Pulmonary Hypertension | Pseudohypoaldosteronism | Wiedemann-Steiner Syndrome | Exocrine Pancreatic Insufficiency | Astrocytoma, Anaplastic | Hereditary Sensory Neuropathy Type 1 | Hypotension, Orthostatic | Leukemia-lymphoma, Adult T-cell | Spinocerebellar Ataxia | Hartnup Disease | Acute Leukemia | Schnitzler Syndrome | Behavioral Variant Of Frontotemporal Dementia | Uveitis | Multiple Myeloma | Fatty Aldehyde Dehydrogenase Deficiency | Congenital Hypofibrinogenemia | Dwarfism | Burn-McKeown Syndrome | Primary Carnitine Deficiency | HANAC Syndrome | Hyperuricemia | Takayasu's Arteritis | Low Tension Glaucoma | Urea Cycle Disorder | Retinal Detachment | Sleep Apnea | Long QT Syndrome Type 1 | Autosomal Recessive Bestrophinopathy | Leishmaniasis, Cutaneous | Chromosome 17q21.31 Deletion Syndrome | Lymphomatoid Granulomatosis | Hepatitis, Chronic | Camurati-Engelmann Disease | Globozoospermia | Anorexia Nervosa | Arthritis, Psoriatic | Thromboembolism | Metanephric Adenoma | Autism | Neuronal Ceroid Lipofuscinosis | Colorectal Adenoma | Hypertriglyceridemia | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Familial Retinal Arterial Macroaneurysm | Keratitis | Dentinogenesis Imperfecta | Angina Pectoris | Hypertelorism | Dystonia | Analgesia | Chronic Granulomatous Disease, X-linked | Pierre Robin Syndrome | Mucolipidosis Type IV | Oligoastrocytoma | Glanzmann Thrombasthenia | Oculocutaneous Albinism Type 4 | Leri Pleonosteosis | Carney-Stratakis Syndrome | Spastic Paraplegia Type 7 | Rhabdomyosarcoma, Embryonal | Melnick-Needles Syndrome | Patent Foramen Ovale | Mandibuloacral Dysplasia With Type A Lipodystrophy | Stuve-Wiedemann Syndrome | Congenital Adrenal Hyperplasia | Vascular Cognitive Impairment | Necrobiosis Lipoidica | CHOPS Syndrome | Premenstrual Syndrome | Chronic Mucocutaneous Candidiasis | Esthesioneuroblastoma | Cardiospondylocarpofacial Syndrome | Desmosterolosis | Kaposiform Hemangioendothelioma | Neurogenic Bladder | Depression | Juvenile Hyaline Fibromatosis | Steel Syndrome | Toxoplasmosis | Liebenberg Syndrome | Carbohydrate Metabolism Disorders | Histiocytosis | SAPHO Syndrome | Pouchitis | Pancytopenia | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Van Der Knaap Disease | Orotic Aciduria | Cerebral Cavernous Malformations | Leukoplakia | Chondroma | Charcot-Marie-Tooth Disease, Type 2C | Plasmacytoma | Spinal Muscular Atrophy Type 3 | Pseudohypoparathyroidism Type 2 | Endophthalmitis | Fibromyalgia | Choroiditis | Familial Digital Arthropathy-brachydactyly | Silicosis | Hypopituitarism | Cancer, Breast | Leukoplakia, Oral | Glycogen Storage Disease Type 4 | Myoclonus | Peyronie's Disease | Coenzyme Q10 Deficiency | Colitis | Intellectual Disability, Autosomal Dominant 5 | Persistent Hyperplastic Primary Vitreous | MELAS Syndrome | Rubeosis Iridis | Atopic Dermatitis | Blepharoconjunctivitis | Thrombophlebitis | Malaria | Fowler's Syndrome | Infectious Diarrhea | Lamellar Ichthyosis | Osteonecrosis Of The Jaw | IMAGe Syndrome | Charcot-Marie-Tooth Disease Type 4E | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Pancreatitis, Chronic | Sclerosing Cholangitis | Spondylolisthesis | Brachydactyly | Pseudohypoparathyroidism Type 1C | Hyperthyroidism | Prediabetes | Schwartz-Jampel-Aberfeld Syndrome | Osteomyelitis | Pierson Syndrome | Hypercholesterolemia, Familial | Kashin-Beck Disease | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Glomerulonephritis, Membranoproliferative | Insulin Resistance | Familial Advanced Sleep Phase Syndrome | Anal Fissure | Colon Adenoma | Infertility, Male | Fucosidosis | LEOPARD Syndrome | Myositis | Hemangioendothelioma | Reye Syndrome | Hypertension, Portal | Pure Autonomic Failure | 3C Syndrome | Sotos Syndrome | Hypothyroidism | Amblyopia | Androgen Insensitivity | Pontocerebellar Hypoplasia | Adams-Oliver Syndrome | Metabolic Diseases | X-linked Sideroblastic Anemia | Gerstmann-Straussler-Scheinker Syndrome | DRESS Syndrome | Nephrocalcinosis | Tinea Versicolor | Gitelman Syndrome | Pemphigus Foliaceus | Essential Fructosuria | Knobloch Syndrome | Hypohidrotic Ectodermal Dysplasia, X-linked | Amelogenesis Imperfecta | Retinal Coloboma | Hypotrichosis | Leiomyosarcoma | Hypercalciuria | Encephalopathy, Glycine | Hyperinsulinism-hyperammonemia Syndrome | Familial Mediterranean Fever | Ataxia-ocular Apraxia 2 | Congenital Torticollis | Familial Exudative Vitreoretinopathy | Charcot-Marie-Tooth Disease | Hashimoto Thyroiditis | Netherton Syndrome | Glycogen Storage Disease Type 5 | Dupuytren Disease | Aplasia Cutis Congenita | Trichuriasis | Phenylketonuria | Papilloma | Neural Tube Defect | Hypoalbuminemia | Prolidase Deficiency | Gastroenteritis | Cerebrotendinous Xanthomatosis | Basal Ganglia Disease | Hyperacusis | Light Chain Amyloidosis | Dubin-Johnson Syndrome