Polymyalgia Rheumatica

About the Disease
Temporal Arteritis, also known as polymyalgia rheumatica, is related to myocarditis and arteritic anterior ischemic optic neuropathy, and has symptoms including back pain, exanthema and muscle cramp. An important gene associated with Temporal Arteritis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and eye, and related phenotypes are joint stiffness and fatigue

Common Targets
CCR6 | HSD11B1 | NR3C1 | NOS3 | IL10 | G7422 | JAK2 | JAK1 | IL6R | IRAK1 | TSBP1 | HIF1A | Interleukin 17 (nonspecified subtype)

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