Disease

Diabetes Type 2

About the Disease
Type 2 Diabetes Mellitus, also known as insulin resistance, is related to diabetes mellitus and maturity-onset diabetes of the young, type 8, with exocrine dysfunction, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Type 2 Diabetes Mellitus is IRS1 (Insulin Receptor Substrate 1), and among its related pathways/superpathways are Nervous system development and Angiopoietin-like protein 8 regulatory pathway. The drugs Glipizide and Glycopyrronium have been mentioned in the context of this disorder. Affiliated tissues include Pancreas and Adipose, and related phenotypes are type ii diabetes mellitus and insulin resistance

Common Targets
TNKS | NPY4R2 | MIR503 | Cyclin B (nonspecified subtype) | MIR486-1 | CX3CL1 | SLC5A2 | SNCA | SREBF1 | TERF2 | NDUFA9 | MLXIP | TUBG2 | CDH13 | IL12B | DDC | MIR30C2 | FAP | HDAC6 | KSR2 | MYO5C | CNTN5 | CDK2 | AVP | CD36 | HRH3 | TRIM66 | G3620 | STN1 | FBXO33 | UGT1A10 | RORC | MFAP2 | UCP3 | FGFR2 | ELP5 | CBR3 | MIR4432HG | CETP | PROKR2 | FMO4 | PRDX1 | MACF1 | APPL1 | EMC10 | G5599 | YKT6 | LOC107986598 | EIF4A3 | NF-kappaB (NFkB) | TLR5 | TNFRSF11B | LOC105375199 | Protein Phosphatase 2A | SMARCC1 | LPL | LTK | BTK | MAP3K12 | PDHX | TMEM106B | APOM | MED23 | Diacylglycerol Acyltransferase (DGAT) (nonspecified subtype) | ATXN7 | LMF1 | PASK | ALPL | MIR374B | HNF1A-AS1 | GSR | ERLIN1 | MALT1 | G595 | BDNF | INPPL1 | ZBTB16 | EPM2A | MIR301B | AMPD1 | TERF2IP | SRP54-AS1 | HIF1A | TENM2 | Carbonic Anhydrase (nonspecified subtype) | MFGE8 | PHACTR1 | NPTX1 | TRIM72 | OGDH | ZBTB38 | PTPN2 | FFAR4 | GPBAR1 | TNFRSF1B | FSCN3 | P2RY1 | MAD1L1 | TFRC | GDAP1L1 | PHGDH | FBXO34 | PPP4R3A | TOMM40 | LOC105372988 | SEMA6A | COL8A1 | Glucosidase (nonspecified subtype) | FN3K | ITGA1 | SLC9A1 | CENPW | DUSP3 | TGFB1 | MTERF2 | GARS1 | MIR1185-2 | LOC100506236 | GPR35 | UVSSA | RGS7 | IL1RN | AMP-activated protein kinase (AMPK) | UBA1 | EFR3B | ATF7IP2 | HFE | HSD17B2 | cAMP Phosphodiesterase (nonspecified subtype) | Prolyl 4-hydroxylase | SLC22A1 | TYW1B | RABEP2 | PDE8A | FADS2 | CFB | GPR119 | RTN4R | SSTR2 | MIR133A1 | TCEA2 | TTR | ZNF76 | FOXO1 | MTCL1 | FOLR2 | KCNAB2 | SEC16B | CDK6 | PRC1 | RAC1 | DNAI2 | MINK1 | ANGPTL4 | TMEM175 | TTLL6 | LINC02576 | Carnitine O-Palmitoyltransferase 1 (CPT-1) (nonspecified subtype) | Tyrosine-Protein Kinases Src (nonspecified subtype) | MARVELD2 | DIO2 | MYD88 | ZNF385D | ATP6V0C | ZFAND6 | PLUT | IGF2R | CYP2A6 | TACR2 | IL37 | ALDH1A2 | TENT5C | LINC00824 | GRB10 | Calpain (nonspecified subtype) | SLC25A25 | RPS6KA2 | IKZF4 | HORMAD2 | MIR133A2 | G207 | FAIM2 | SCAANT1 | PTPRD | INSIG1 | PDK1 | UBE2Q2 | Kainate Receptor (GluR) (nonspecified subtype) | ASB5 | KCNA3 | MOGAT2 | LCORL | GHRL | TAB1 | PURG | ADAMTS6 | TRMT9B | POTEC | CRTC2 | CISD2 | GBA1 | GHSR | ZPR1 | CCND2 | RALGPS2 | CPT1C | SREBF2 | SORBS2 | MKNK2 | MAP2K7 | GDF15 | CRY2 | MIR411 | OVOL1 | POU2F1 | KIF9-AS1 | TIMD4 | LOC105375490 | SAMD12 | HAPLN4 | MIR421 | TNRC6A | TMPRSS15 | PITPNM2 | L-type voltage-dependent calcium channel complex | Voltage-gated K(v) channel (nonspecified subtype) | G7099 | SCAF8 | CA5A | MADD | PTPRS | BMAL1 | DNMT3A | SMG6 | LARS2 | KCNK16 | RAI1 | HP | SGCG | SLC12A3 | EIF2S1 | EXT2 | TRIB1 | GRB14 | LOC105375494 | RASA1 | RYR1 | LRRC74A | MIR124-1HG | SLC16A13 | SLC16A9 | CDK4 | GTF2I | PLSCR4 | TMEM135 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | G673 | MIR23A | TCF12 | TOP1 | WARS1 | PDE4B | CASP5 | UGT1A8 | TSPAN2 | LOC101927825 | PRKCZ | SRSF10 | G59272 | IKBKB | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | CYP7A1 | LGALS3 | NR1H2 | AQP10 | ABCA7 | ZNRD2 | LOC105377462 | THRB | NDUFS2 | DDHD2 | DGAT1 | SLC6A20 | CCNH | CTNNA3 | GSS | LOC105370832 | C3orf49 | CHST8 | GLIS3 | MTNR1A | OPRM1 | GPSM1 | IL2RA | ACE | OXCT1 | PDZK1 | FFAR1 | ABCC12 | P2Y purinoceptor (nonspecified subtype) | AQP9 | LRMDA | CERT1 | MYOM2 | CYSLTR1 | PKIG | RARA | CDK5/p25 | TTC7B | CAVIN3 | G6PC2 | APOA5 | Mitogen-Activated Protein Kinase (MAP Kinase)-Activated Protein Kinase (nonspecified subtype) | SRR | CHST6 | SYNE2 | SLC19A3 | DNMT3L | LOC105375508 | Glycogen phosphorylase (nonspecified subtype) | DRD4 | LDLRAD4 | SH2B1 | RAB11B | NOS1AP | PTGER3 | Protein kinase C (nonspecified subtype) | NFKB2 | F11R | CMIP | ZC3H12C | SLC7A7 | AURKB | CELF1 | SPPL3 | GUSBP1 | G7295 | CADM2 | NAT2 | NAE1 | RTN4RL2 | VOR Complex | CYB5A | CYP21A2 | CA1 | IP6K2 | POR | GNB3 | TSPAN8 | FDFT1 | IL6-AS1 | AAMDC | BMAL2 | ADRA2B | NPY1R | ACP1 | P4HA3 | FAM13A | TXNRD2 | GGT6 | CNR2 | ITGA2 | KCNK1 | LTA | TGM1 | MGAT2 | PDXDC1 | RASGRP1 | TENM2-AS1 | LOC107987099 | SUGP1 | MGLL | CD200R1L | G598 | LAG3 | G1950 | EPHX2 | G4780 | G1029 | ADIPOQ | G1/S-specific cyclin-E (nonspecified subtype) | COBLL1 | TMEM163 | PDE8B | FBRSL1 | JARID2 | SLC39A11 | NDUFV1 | RGS17 | PKN2-AS1 | NOD1 | NPC1L1 | G1432 | CYP17A1 | PNPLA3 | PPARA | Calcium channel (nonspecified subtype) | DENND2C | NAIF1 | UBE2D3 | SLC7A11 | CDKN2B | G3479 | AGT | ALDH2 | CES2 | IPO9-AS1 | TM4SF4 | MNT | SPHKAP | ALOX12 | CAMK2G | DSTYK | ARPIN-AP3S2 | CD69 | KLB | SPAM1 | FNDC5 | IRS2 | FTX | SBNO1 | DUSP22 | HLA-DQA1 | LRFN2 | mTOR complex 1 | CTSS | BMX | DRD2 | ESR2 | REEP3 | CTDSP2 | UBA3 | SLC17A3 | TCF19 | MYO10 | G5563 | MMS22L | NR1H3 | PPM1K-DT | ZEB2 | TDRP | DNA Topoisomerase II (nonspecified subtype) | NLRC3 | CCDC92 | PDK2 | GH1 | GIP | ADCY3 | HS3ST4 | HRH2 | SCD | EGR1 | MAP3K5 | MT1A | DGAT2 | GCK | POMC | MAPK11 | CHRM1 | Lipoxygenase (nonspecified subtype) | MAOA | ANGPTL3 | CDK5 | EGFEM1P | Mucin (nonspecified subtype) | CDK9/Cyclin T1 | ST6GAL1 | Serine palmitoyltransferase | TMEM131 | PKLR | LOC105375716 | BEND3 | AP3S1 | COMT | APLNR | UGCG | HMGA2 | PDE1C | SENP2 | IL-1 Receptor (nonspecified subtype) | LINC00261 | PRICKLE2 | UBE2E2 | CALM1 | CASR | PDCD4 | CDKAL1 | CDKL2 | PTPRF | LINC03019 | CTSE | LINC02603 | C11orf65 | ASXL3 | EHF | UBE3C | USP19 | Casein kinase I (nonspecified subtype) | RECQL | CPT1A | G142 | Estrogen receptor (nonspecified subtype) | LRP5 | MS4A18 | ACSL1 | TMCC1 | TNIK | BRD4 | JAZF1-AS1 | PROCR | RTN4 | TSHZ3 | MYSM1 | UGT1A7 | PAPSS1 | SCARB1 | EHD4 | KEAP1 | BAK1 | SLC22A3 | TBCD | PRKRIP1 | RBFOX2 | PIP5K1B | PGR | PIK3CD | HDAC5 | HSF1 | SLC22A12 | ADP-Ribosyl Cyclase/cyclic ADP-Ribose Hydrolase (ADPRC) (nonspecified subtype) | Integrin alpha4beta7 (LPAM-1) receptor | Sodium-Glucose Cotransporter (SGLT) (nonspecified subtype) | FBXL13 | YWHAH | MEX3A | TXNIP | GALNTL6 | ACAD10 | PEG3 | CCKBR | PRKD1 | PDE10A | MIRLET7BHG | TCF4 | MLXIPL | ABCG1 | HMGCR | KIF12 | HTR4 | IMPA2 | TMOD1 | RPSAP52 | JMJD1C | OGG1 | WWOX | HTR1A | ICAM1 | SSTR3 | PIM3 | FARSA | MKNK1 | TNFSF11 | HDAC3 | LOC105377858 | TEX14 | RALY | KDSR | GFPT1 | SETD5 | HCRTR1 | DOCK6 | Protein Tyrosine Phosphatase (PTP) (nonspecified subtype) | KHK | TMPRSS6 | G7157 | CCDC88B | CHFR | LOC105375745 | HADHB | CD44 | CLK4 | RPS6KB1 | ADORA2B | SLC6A2 | IL17REL | P2RX3 | NOX4 | BACE2 | ADORA1 | NOD2 | HHIP | TRAF6 | NAPEPLD | HDAC1 | PTPRG | SLC1A5 | UBE2Z | G23411 | GALR3 | CDK9 | TNFRSF19 | SHBG | ADAM17 | MRC1 | PDE9A | SORBS3 | NAV1 | PAK5 | G1385 | MIR24-2 | RERE | G2475 | FPGT-TNNI3K | TSBP1-AS1 | PDZRN4 | LAMB3 | EYA2 | PAX4 | GALNT2 | BARX2 | CDKN2B-AS1 | ADIPOQ-AS1 | ATF7 | NR4A1 | AKAP13 | SINHCAF | Liver Bile Transporters (LBAT) (nonspecified subtype) | ARG1 | TBCE | MIR375 | ZFP91 | WAC | CHCHD6 | PINX1 | HTR2B | AMP-activated protein kinase alpha2beta1gamma1 | ARX | TMEFF2 | NXPH1 | HLA-DOB | TREH | SHROOM3 | CNR1 | CTRB1 | MIR122 | EVC | MGAT4FP | POU5F1 | DOK7 | PSMC3IP | CELF4 | SAT2 | ATP2A1 | FMO5 | ERRFI1 | IMP3 | LOC105369367 | BMP8A | ABCA1 | IGFBP2 | MICB | ADAM19 | SMARCAD1-DT | ANK1 | MIR181D | RNF10 | PTPN9 | Chloride channel (nonspecified subtype) | SMPD1 | DACH1 | SUPV3L1 | FHIT | PCSK2 | NR5A2 | PPARG | ANGPT2 | TRANK1 | NADH dehydrogenase (Complex I) | CDK8/Cyclin C | Opioid receptor (nonspecified subtype) | LOC100630923 | ZNHIT3 | AMP-activated protein kinase alpha1beta1gamma1 | CACNA1C | SBF2 | ELP1 | LOC100287329 | NR1I2 | ILDR1 | SELENOS | DPP7 | TIRAP | NANOS3 | COL5A1 | CCN2 | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | DYRK1A | NPY2R | GINS2 | PCSK9 | CIZ1 | TXN2 | CCHCR1 | ACVR2A | FGD6 | PSMD9 | GPR142 | IL-4 receptor | Oxysterols receptor LXR (nonspecified subtype) | Acetylcholine Receptors (Nicotinic) (nAChR) (nonspecified subtype) | ATP8A1 | HSD11B1 | AMP-activated protein kinase alpha2beta2gamma2 | GABA(A) receptor | NTRK3 | TNNI3K | CAPN3 | EPPK1 | PFKFB3 | HHEX | LINC01122 | MIR133B | ATP1B2 | CDHR18P | MIR23AHG | PYGB | Tyrosine Kinase (nonspecified subtype) | Reverse transcriptase (Telomerase) | KIF3C | SOD2 | CCR2 | UBE2N | VCAM1 | Gap junction Connexin ( (nonspecified subtype) | MARCHF10 | ALCAM | TAS1R2 | G5595 | PSMA6 | SEPTIN9 | RCN1 | SARS1 | AMP-activated protein kinase alpha2beta1gamma2 | CYP2C8 | STX12 | PRKAG2 | VPS53 | IAPP | APOC3 | PGAM5-KEAP1-NRF2 Complex | HAPLN3 | SHC1 | BAIAP2L2 | PIP4K2B | SNORA70F | GPX1 | LOC105377989 | CD38 | PTGS1 | CHRNA7 | NEK7 | TPTEP1 | EHBP1 | ARID5B | B4GALNT1 | TM6SF2 | PDCD6IP | PPARD | DPP8 | CCNT1 | TBC1D4 | CCAR2 | ADRB3 | TRPV1 | CPT2 | GADD45A | DPP4 | MIR21 | MTNR1B | GLO1 | DLEU1 | STK11 | MLX | TGM2 | G2099 | PDK4 | C7orf50 | CACNA1C-AS4 | BCHE | ADORA2A | ADRA2A | ARNT | ST7 | AMHR2 | XKR6 | REV3L | Chaperone (nonspecified subtype) | INSR | ABCB10 | Amylin receptor | G3605 | SELP | MIR181C | WDR7 | PRICKLE2-AS2 | G9429 | Casein kinase II (CKII) | UGT1A4 | CDC123 | PYGL | MIR124-1 | DNMT3B | PKHD1 | TET2 | LOC105369612 | LOC105371356 | RHEBL1 | G3480 | RPS10 | RTN1 | UBQLNL | SLC16A1 | CYP24A1 | GIPR | EIF2S2 | RCCD1 | MAP3K13 | GSTT1 | ARAP1 | Neurotrophic Tyrosine Kinase Receptor (TRK) (nonspecified subtype) | ABCB9 | IL27 | VPS26A | MIR518B | PTPN1 | KCNC3 | KCNE1 | FLI1 | TET1 | CACNA1C-IT2 | TXNDC9 | PPP1R3A | FFAR2 | ZNF641 | EPO | NPPA | OXT | IRAK4 | TNKS2 | RBM6 | AKT2 | MAP1LC3B | RETREG3 | ACHE | AKR1B1 | CLMP | ACP5 | LOC100129175 | MAPKAPK2 | FDX2 | ADH1B | cAMP-Dependent protein kinase (PKA) | SLC22A2 | SERPINE1 | NPPA-AS1 | GSK3B | SPTY2D1 | TKT | POLK | CASP4 | BIN3 | Voltage-Gated Sodium Channel Complex | CSMD1 | F2 | MUC5B | XDH | XRCC3 | GCKR | SUSD4 | LOC105369705 | MAP4K4 | CES1 | USP3 | ZFAND3 | CELSR2 | PC | CTSH | PHOSPHO1 | MIR338 | FGFR1 | CPEB3 | NPY | LRRC31 | JADE2 | TNFRSF12A | GTF2I-AS1 | SYNGR1 | GADD45G | BIRC6 | RORA | EBF2 | NADK | DNAH8 | MIR26A2 | PIKFYVE | G2309 | TKTL1 | VPS33B | HMG20A | CNTF | NDUFAF6 | DAPK1 | P2RX4 | UGT1A6 | CWF19L1 | MAPK9 | ELMO1 | COL1A2 | MIR26B | ZHX3 | ORC4 | KCNMB3 | TRIM59-IFT80 | SOCS3 | RNPC3 | LOC105369709 | LOC105378088 | CXCL12 | AKAP1 | TSKU | UGT1A9 | Orexin receptor (nonspecified subtype) | USF1 | ENDOD1 | POT1 | C1orf167 | PCSK7 | ADCY5 | G3630 | MEN1 | FABP5 | R3HDM1 | PRL | AATK | RB1CC1 | 15-Lipoxygenase (nonspecified subtype) | BACH2 | HIGD1C | LOC157273 | ZBED3-AS1 | PCBD1 | SLC2A10 | G836 | KIAA0825 | NFE2L3 | COL5A2 | CCL13 | P4HB | PRKCD | SLC6A19 | SLC5A4 | STAT2 | TLR2 | G7124 | MYH2 | NPPB | NPY5R | TINF2 | RBMS1 | KCNA5 | C1QA | OPRD1 | UBR2 | STK32C | NPY4R | UHRF1 | LOC105371642 | SLC2A7 | EVI2B | NFE2L1 | GGA3 | QSER1 | AFF2 | PLA2G6 | OTULINL | GRM8 | NEDD8-activating enzyme E1 | LYPLAL1 | ADORA3 | TFAP2B | TRPC6 | MX1 | ZNF771 | PCLO | GRK4 | NUS1 | COMMD1 | Mitogen-Activated Protein Kinase (nonspecified subtype) | TLE1 | G4318 | SF1 | P2RX5 | MTCH2 | KIFBP | GATAD2A | FAM135A | K(ATP) Channel (nonspecified subtype) | FBXO36 | XRRA1 | SKOR1 | NAGA | JAZF1 | SUGCT | SMIM6 | GRID1 | NR3C1 | CD7 | CYP2R1 | CDK1/Cyclin B | DHCR24 | SMAD2 | WFS1 | CALCA | ADIPOR1 | FOCAD | LOC101929457 | IARS2 | NR1H4 | AMZ1 | BLTP1 | KLF11 | HAVCR1 | DDX56 | SUCNR1 | HMGA1 | Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) (nonspecified subtype) | ALMS1 | CDKN2C | CTNNBL1 | MRPL3 | Glucagon-like peptide receptor (GLP-R) (nonspecified subtype) | SLC10A1 | LIPC | TNR | ESRRA | GOLM1 | ITLN1 | ACVR2B | UBAP2 | ARHGEF11 | MAP Kinase-Interacting Serine/Threonine-Protein Kinase (nonspecified subtype) | ADRB1 | Triacylglycerol Lipase (TG Lipase) (nonspecified subtype) | PSORS1C1 | LRP1 | AMPD2 | PEMT | HCRTR2 | Pyruvate dehydrogenase kinase (nonspecified subtype) | OSBPL7 | RBP1 | KCNK3 | Glycogen synthase kinase 3 (GSK-3) (nonspecified subtype) | MBL2 | G2033 | BDNF-AS | TRIM46 | FRMD5 | BCL2L11 | GPX3 | FHOD1 | SLC19A2 | KMT2A | FOLH1 | G6PC1 | LINC02451 | G9734 | BICD1 | MTTP | AKR1C3 | UGT1A5 | CDH11 | BCAT1 | FSD2 | G367 | STS | ANKDD1B | NFKBIL1 | KLF7 | NADSYN1 | CHRM3 | RARB | ABCG8 | STK3 | CACNA1D | ASCC2 | GPR84 | ADAMTS9-AS2 | SRPRB | RTN4RL1 | SLC17A1 | MIR27A | G4193 | ELAVL4 | ATP2A3 | SLC22A18AS | FIS1 | MTA2 | HDAC4 | CHUK | OR2T11 | Sodium channel (nonspecified subtype) | G4233 | NAGLU | PAM | HERC1 | NRXN1 | Class III phosphatidylinositol 3-kinase (PI3-kinase) sub-complex | CTLA4 | MARK3 | CLUAP1 | TNFRSF11A | PABPC4-AS1 | S100A9 | POC5 | SNAI1 | LEPR | FBXO38 | FAM234A | ABTB2 | HMGA2-AS1 | EIF2AK1 | GLUD1 | LINC02060 | SLC40A1 | KCNQ1OT1 | NUAK1 | PTPRT | HSD17B13 | Prostanoid TP receptor (nonspecified subtype) | SMARCD3 | BPTF | PDE3B | PIK3CA | CCNT2-AS1 | HCAR1 | LOC646736 | SPTBN1 | ABCC8 | KDM2B | KCNE3 | CCNE1 | PPP5C | G5743 | GLT6D1 | BLK | CYP3A5 | STAT4 | SYMPK | CALCRL | RXRA | SLC47A2 | CCDC80 | GOLT1B | PDE6D | PDE1B | CNDP1 | PRC1-AS1 | CTDSPL | PIK3C3 | FEM1B | CPQ | ERI3 | CCDC170 | ARRDC2 | LRRC8A | NPEPPS | PNPLA2 | PDX1 | SFTPD | FASN | DDR1 | DGKD | PRKCI | HBB | ELOVL5 | EDN1 | LIN28A | PIM1 | LOC105371814 | OGA | ADCYAP1R1 | COPB1 | CDK2/Cyclin A | HNF1A | FLT3 | HSD17B12 | SNAP25-AS1 | AP3S2 | CCNQ | PSMC2 | TP53RK | CCDC68 | KCNE4 | PEPD | LOC100507156 | ARL15 | DLL1 | HTR3B | IL1A | MLL/SET1 Complex | STK33 | VDR | SIK2 | PDE2A | G5243 | PTPRN2 | Carnitine O-palmitoyltransferase 2 (nonspecified subtype) | KCNQ1 | NEUROG3 | ZBTB20 | STX18 | NBPF20 | LOC101929615 | MOGAT1 | ACMSD | MSMO1 | NUAK Family SNF1-like Kinase (nonspcified subtype) | Heat shock protein 70 (nonspecified subtype) | Dopamine receptor (nonspecified subtype) | Glycine receptor | CYP26A1 | NOS3 | MAPRE1 | NUCB2 | KARS1 | PEBP4 | MIR194-1 | SCARA3 | CYB5R1 | MRI1 | UNC5C | ANKH | FAM99A | HSD11B2 | SLC22A4 | SGMS2 | MTHFR | FBP1 | ZNF365 | CRTC1 | LINC02740 | CDC25A | MMP2 | ESRRB | UCHL1 | FGF1 | ACP6 | NUTF2 | FASLG | OLR1 | AMT | LOC105369781 | HOOK2 | NRXN2 | Sterol O-acyltransferase (ACAT) (nonspecified subtype) | APOC1 | CPE | SLC6A4 | SLC16A11 | TXNRD1 | SEM1 | AOPEP | PTPRU | LAMA1 | CYP26B1 | CLK1 | AQP5 | Poly [ADP-ribose] polymerase (nonspecified subtype) | DPP6 | GGT1 | LOC100288637 | CDKN1B | LPIN2 | PTPN4 | HTR6 | G5970 | CNIH3 | L-Type calcium channel (nonspecified subtype) | STK4 | CYTH1 | GYS1 | GMEB1 | RAB1A | CRYBA2 | TRHR | CLEC16A | CARMIL1 | PROKR1 | SCYL1 | PLEKHA1 | Vasopressin Receptor (nonspecified subtype) | BDKRB1 | SLC34A1 | LYN | ERBB4 | CA2 | USP44 | CNTNAP2 | GRK5 | CXCR2 | Cryptochrome (nonspecified subtype) | MIR215 | PDE5A | LOC101929698 | ABR | LRRC38 | CPNE4 | IFIH1 | MBNL1 | PAX6 | TAOK3 | SLC10A7 | MSTN | LOC105372130 | FAF1 | IL10 | SLC2A1 | ADIPOR2 | PON1 | LANCL2 | NFAT5 | ZNF800 | FANCF | GC | SLCO4A1 | DYRK1B | HK2 | SP7 | MOGAT3 | MRPS35 | AFF3 | G1786 | ERN1 | FBXO31 | EP300-AS1 | KCNE2 | Adenosine receptor (nonspecified subtype) | MIR29A | ENPP1 | FGFRL1 | HYDIN | AKAP3 | ACACB | PTH1R | APOA1 | SHROOM1 | KDR | Cannabinoid receptor (nonspecified subtype) | LINC02232 | PAX8 | PAK1 | PDE11A | TNFRSF10D | GIN1 | LOC101929710 | NMUR1 | TP53INP1 | CRYZL2P-SEC16B | CHRM5 | CREBRF | G672 | MAN2A2 | TH | TTN | TPCN2 | NOX3 | PCK1 | OASL | MAPK10 | SLC9B2 | SLC5A1 | MDGA2 | SCD5 | MIR4709 | MSI2 | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | CYP2C9 | TRPS1 | SRGAP2 | CCKAR | BCKDK | INTS8 | LINC02456 | RBL2 | NMDA receptor | SPRED2 | SETX | AGBL2 | RTBDN | AHI1-DT | RMC1 | SDCCAG8 | Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase (SERCA) (nonspecified subtype) | SDHAF4 | NOL4L | AMTN | MIR146A | TALDO1 | ALDOC | DMXL2 | SCHLAP1 | BMF | IGF2BP3 | JAML | RNF6 | ZNF664 | G1956 | AFF1 | GAA | TBL2 | LOC105369944 | METAP2 | Fructose-Bisphosphate Aldolase (nonspecified subtype) | KCNS3 | ADRB2 | Fatty Acid Binding Protein (nonspecified subtype) | TOP2A | NFYC | TLCD3B | UNC80 | Cyclooxygenase (COX) (nonspecified subtype) | SLC10A2 | GLB1 | PATJ | HTT | CYSLTR2 | HTR2A | IFNG | ACD | DTNB | G3082 | CORIN | CDK2/Cyclin E | DAGLA | PLA2G2D | CISD1 | HPSE | RXRB | SSR1 | CCSER1 | LRP2 | MIR296 | NAMPT | BCAS3 | GLP2R | A1CF | MASP1 | MIR299 | AGTR1 | NOTCH2 | SLMAP | PTGES2 | MAEA | PRKCQ | LOC105374756 | CHD4 | AGMO | SSTR5 | TACR1 | ESRRG | SLC2A9 | CA5B | TRIB3 | INS-IGF2 | KIF6 | PLA2G7 | SIRT4 | WT1-AS | G6PD | SLC43A1 | PABPC4 | RPS10-NUDT3 | SOCS2 | HCAR3 | LOC105374778 | SLCO1B1 | Cyclin A (nonspecified subtype) | FBXO32 | Mitochondrial pyruvate carrier complex (MPC) | Cytochrome P450 4A (nonspecified subtype) | LIPE | AGER | ANKRD28 | TRPA1 | BAZ1B | Phospholipase A2, Secretory (sPLA2) (nonspecified subtype) | CCR5 | CREBBP | CPEB1 | KCNH1 | Histone deacetylase (nonspecified subtype) | SGIP1 | GDF9 | IFNL4 | LOC105372326 | HSD17B1 | Large Conductance BK(Ca) Potassium Channel (Maxi K+ Channel) (nonspecified subtype) | CIDEC | MC4R | CFAP69 | CADM1 | EML3 | LINC00907 | LOC101928417 | GSTM1 | STARD10 | NUDT6 | GBA2 | AGTR2 | PDILT | ALB | G7422 | RFX6 | ITIH5 | ANKFY1 | FYN | GJD2 | HNF4A | ARID4A | SGCZ | TNRC18 | KCNK17 | Uncharacterized LOC101928423 | CAGE1 | FST | G3146 | PTPN11 | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | Sphingolipid delta(4)-desaturase (nonspecified subtype) | ZNF408 | KRTAP4-3 | EPB41L4B | CERS5 | GSTP1 | BTBD9 | Proteasome Complex | VDAC1 | ACLY | TNFRSF10C | NR1D1 | APOB | SELENOP | CYP19A1 | DGKB | SPDEF | WSCD2 | PTPMT1 | HMGB4 | PPARGC1B | Glycogen synthase (nonspecified subtype) | CASP1 | UGT1A1 | PROX1 | CEP350 | NUDT3 | Gap Junction Protein (nonspecified subtype) | CDK7/Cyclin H | SRSF12 | Integrin alphavbeta1 | Angiotensin receptor (AT) (nonspecified subtype) | TBXA2R | MEIS2 | P2RX7 | DNM3 | GATA3 | APBA1 | MIF | R3HDM2 | FTO | ARID1A | CHD6 | APLN | CFH | ZNF704 | NADPH Oxidase Complex | DEFB1 | HAUS6 | TEP1 | ABCC1 | MIR657 | ATF6 | ZC3H4 | LOC101927394 | C5orf67 | CALCOCO2 | CREB5 | PARK7 | HCAR2 | TSHZ2 | MIR29B1 | TNRC6C | HIVEP3 | VWA3A | SPOCK1 | MSRA | MTIF3 | ZNF229 | TNRC6B | PDGFA | PIP4K2A | CCL2 | SLC2A2 | FOXO4 | DDAH2 | GCG | PNLIP | GRM4 | MINDY1 | HTR2C | CTDSP1 | RXRG | Retinoid RXR receptor (nonspecified subtype) | ADRA1B | RCAN1 | COL27A1 | IGF2BP2 | RETN | IRAK1 | PRDX2 | FABP4 | UCP1 | ABO | CTBP1 | CYP4A11 | MIR196A2 | CALCR | MADCAM1 | RXFP4 | CRY1 | SLCO1A2 | PCNT | CTDSPL2 | RNU5E-1 | SND1 | LOC105374968 | IDE | RAP1B | LPA | AHSG | MYBL2 | PID1 | RBPJL | APOE | alpha-Amylase (nonspecified subtype) | TSPO2 | NPC1 | TMEM165 | FSTL1 | MAP4K2 | SLC30A8 | ALOX5 | TLE1-DT | LOC105378980 | Fibroblast Growth Factor Receptor (FGFR) (nonspecified subtype) | Ras GTPase (nonspecified subtype) | DEGS2 | CLDN7 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | MIR128-1 | PROX1-AS1 | TREML4 | GPR39 | PSMD6 | IL4 | TNFRSF1A | XRCC1 | CRBN | DOCK7 | DEGS1 | MAML3 | LRRFIP2 | TSBP1 | CDK1 | FMN1 | NLRP3 Inflammasome | ZZEF1 | LOC101928499 | WSB2 | SPOCK2 | CSMD2 | PLEKHM3 | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | MIR29B2 | NNMT | ZNF236 | OPCML | THOC7 | GALR2 | WBP1L | LINC02537 | TBK1 | ACACA | 11beta-Hydroxysteroid Dehydrogenase (nonspecified subtype) | KIF9 | SERPING1 | PITPNC1 | MICA | G596 | Potassium Channels (nonspecified subtype) | BOP1 | CTTNBP2 | GLP1R | DPP9 | CCND2-AS1 | PRKCE | Voltage-Gated Calcium Channel alpha-2/delta (nonspecified subtype) | MBOAT4 | Mitogen-activated protein kinase (JNK) (nonspecified subtype) | GRK2 | CYP11B2 | MTHFD2L | AUTS2 | RSPO3 | TRUB2 | PARL | BARX1 | PTPRC | RREB1 | UNC5D | JAK3 | SLC6A3 | Rho kinase (ROCK) (nonspecified subtype) | MAOB | ALDH1A3 | OXTR | DOCK9 | LOC105379030 | PPARGC1A | G8878 | CDKN1C | HNF4G | CRHR2 | KCNA2 | DCUN1D4 | PRKN | G5347 | PON2 | AMY2B | LOC105372666 | Ribosomal Protein S6 Kinase, 70kDa (p70S6K) (nonspecified subtype) | IL1B | IRS1 | METTL15 | PCK2 | HOTAIR | MCHR1 | NHERF1 | LINC02571 | TAAR1 | HECW1 | CUX2 | BFSP2 | PNLIPRP1 | NMUR2 | ABL1 | FAM99B | MIR5009 | P4HA2 | CDK7 | DLGAP2 | IKBKE | IP6K1 | DENND1A | NADPH Oxidase (nonspecified subtype) | SLC1A2 | G7015 | PIK3CG | PELO | TMEM161B-DT | CACNA2D3 | GPR55 | PDGFC | MIR499A | ARHGAP22 | HRH4 | IL13 | CXCL11 | CTNND2 | THRA | TXK | FABP2 | NLGN1 | CYBRD1 | RPAP1 | GPR17 | WDR46 | CLCN6 | IGF2 | G3569 | IL18 | IL23R | HNF1B | GRK6 | MAPK8IP1 | LOC107986141 | YTHDC2 | SLC2A4 | CAMK1D | Na+/Ca2+ Exchanger (NCX) (nonspecified subtype) | ROBO2 | ATXN2 | IGF2-AS | ATF7IP | LIPG | LOC105379044 | CHGA | LTB4R | G3576 | Melanin-concentrating hormone (MCH) receptor (nonspecified subtype) | PML | SLC47A1 | RELN | ADAM30 | FADS1 | TCF7L2 | UBR1 | FBXO11 | GAS6 | NPC2 | HMOX1 | NGF | TMC7 | SLC12A8 | MIR1185-1 | PPT1 | G114548 | MIR29C | NR2F6 | BBS10 | CAMK2B | TNFRSF10B | RRN3 | LOC101928635 | LOC107986166 | WDFY2 | KCNB1 | MC5R | ZFR2 | PDE7A | MPHOSPH9 | PCGF3 | ONECUT1 | AURKA | PGM1 | CNTNAP1 | MIR1322 | STRBP | LOC105375043 | RECQL5 | CAMKK2 | CTSD | MIRLET7A3 | DPYD | OR5D18 | UCP2 | GLA | HLA-DQB1 | PTPN6 | THADA | SCN5A | ELOVL6 | CD81-AS1 | LOC107986257 | HOXA5 | IP6K3 | RPS6KA1 | CPA1 | SLC9B1 | NTRK2 | FOXJ2 | ZMIZ1 | RAD51B | DVL1 | SAMM50 | AGBL4 | LOC105370275 | LOC105375047 | Epoxide Hydrolase (nonspecified subtype) | BNIPL | MIRLET7B | NFKB1 | ALOX15 | SIRT6 | TAS1R3 | PLCB3 | ZNF664-RFLNA | CDKL1 | LOC105379185 | CD226 | CARMIL2 | TERF1 | MFSD9 | RIPK2 | GNA12 | RFT1 | INKA2 | DNA-Directed DNA Polymerase Complex | CYP51A1 | Mitogen-activated protein kinase p38 (MAPK p38) (nonspecified subtype) | ETS1 | LPIN1 | GCGR | NOL4 | PPM1G | SHQ1 | G5562 | C17orf58 | KLF4 | LOC105370359 | LOC105375069 | G6774 | MIR30A | UGT1A3 | LIPC-AS1 | MBD5 | RABGGTA | MIR30B | PCSK1 | ZNF34 | PEX14 | ADGRG7 | AHI1 | CNTNAP2-AS1 | GSK3A | SLC22A11 | Phosphodiesterase (nonspecified subtype) | MDM4 | IFT172 | ESRP1 | LOC101928718 | MIR7107 | MAP2K5 | LINC01141 | MIR483 | VAMP2 | PLA2G2A | DCAF5 | TCP11L1 | PKDREJ | HLF | MMP16 | CAT | LINC01978 | LYPLAL1-AS1 | MYNN | CAPN10 | KCNJ11 | LINGO2 | ART3 | CUBN | G5133 | ENPP2 | PTGFRN | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | CYBA | Glutamate Receptor Ionotropic AMPA Receptor | MIR30C1 | TRIM37 | SIRT2 | LIPF | NRXN3 | HLA-DQB1-AS1 | AKR1C4 | CYP3A4 | C4orf50 | CEP68 | RNLS | SORBS1 | LDLR | MIR130B | CASQ1 | SLX4

疾病靶点研报
Diabetes Type 2

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Other Diseases

Familial Exudative Vitreoretinopathy | Sarcoidosis, Pulmonary | Mumps | Hypertensive Retinopathy | 3-methylcrotonyl-CoA Carboxylase Deficiency | Huntington's Disease-like 2 | Von Hippel-Lindau Disease | Congenital Torticollis | Long QT Syndrome Type 1 | Synovitis | Myopia | Hypertension, Pulmonary | Spinocerebellar Ataxia Type 42 | Blood Protein Disorders | Uremia | Multiple Sclerosis | Ectrodactyly | Thrombotic Microangiopathy | Hyperkalemic Periodic Paralysis | Carcinoma, Transitional Cell | GAPO Syndrome | Esthesioneuroblastoma | Cheilitis | Hyperbilirubinemia, Neonatal | Sarcoma | Charcot-Marie-Tooth Disease Type 2E | Polyradiculopathy | Williams Syndrome | Unverricht-Lundborg Syndrome | Lesch-Nyhan Syndrome | Hereditary Inclusion Body Myopathy | Osteonecrosis Of The Jaw | Traboulsi Syndrome | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Diabetic Encephalopathy | N-acetylglutamate Synthase Deficiency | Personality Disorders | Hypomyelination With Atrophy Of Basal 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Deficiency | Polyomavirus Nephropathy | Danon Disease | Inflammatory Myopathy | Ameloblastoma | DRESS Syndrome | Cold-induced Sweating Syndrome | Amyloidosis | Pemphigus Foliaceus | Central Core Disease | Feingold Syndrome | Ollier Disease | Mitochondrial Disease | Sertoli Cell-only Syndrome | Pseudoexfoliation Syndrome | Nevus | Niemann-Pick Disease, Type C | Retinoschisis | Tylosis With Esophageal Cancer | Focal Dermal Hypoplasia | Hypohidrotic Ectodermal Dysplasia, X-linked | Anxiety Disorders | Neuroma | Spinocerebellar Ataxia Type 31 | Familial Hyperaldosteronism | Thrombosis | Raynaud Phenomenon | Congenital Bile Acid Synthesis Defect | Renal-hepatic-pancreatic Dysplasia | Congenital Stationary Night Blindness | Melanoma | Cockayne Syndrome | Myofibrillar Myopathy | Nemaline Myopathy | Tendinopathy | Meningioma | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Diabetes Insipidus, Neurogenic | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Noonan Syndrome-like Disorder With Loose Anagen Hair | Charcot-Marie-Tooth Disease Type 4 | Mannosidase Deficiency Diseases | Acute Kidney Injury | Sick Sinus Syndrome 1 | Erythema Multiforme | Vitamin A Deficiency | Cancer, Prostate | Recurrent Respiratory Papillomatosis | Neurocutaneous Syndromes | Achromatopsia | Schwannomatosis | Cousin Syndrome | Kabuki Syndrome | Xeroderma Pigmentosum | Dyslexia | Esophageal Motility Disorders | Schaaf-Yang Syndrome | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Multiple Sulfatase Deficiency | Pancreatitis, Chronic | Spondylometaphyseal Dysplasia | Carey-Fineman-Ziter Syndrome | Hyperekplexia | Bacterial Meningitis | Paroxysmal Nocturnal Hemoglobinuria | Erythropoietic Protoporphyria | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Demyelinating Diseases | Narcolepsy | Intestinal Hypomagnesemia 1 | Impulse Control Disorder | Essential Fructosuria | Alpha-1 Antitrypsin Deficiency | Hereditary Spastic Paraplegia | Endometrial Hyperplasia | Neurodegeneration With Brain Iron Accumulation | Bronchitis | Alpers Syndrome | Hereditary Hemorrhagic Telangiectasia Type 2 | Restrictive Dermopathy | Vaginitis | Peters-plus Syndrome | Periodic Limb Movement Disorder | Silver-Russell Syndrome | Sleep Apnea, Obstructive | Pelvic Inflammatory Disease | Hypertension, Renovascular | Stiff-man Syndrome | Primary Hyperoxaluria Type 1 | Nager Acrofacial Dysostosis | Arthritis, Psoriatic | Conn Syndrome | Crigler-Najjar Syndrome | CREST Syndrome | Isobutyryl-CoA Dehydrogenase Deficiency | Oligoasthenoteratozoospermia | Polycythemia Vera | Wolcott-Rallison Syndrome | Alzheimer Disease, Late Onset | Placenta Previa | Ophthalmia, Sympathetic | Facioscapulohumeral Muscular Dystrophy | Rhabdomyosarcoma, Embryonal | Retinal Dystrophy | Holoprosencephaly | Poretti-Boltshauser Syndrome | Cocaine-Related Disorders | Centronuclear Myopathy | Pericarditis | Lysosomal Acid Lipase Deficiency | Multiple Epiphyseal Dysplasia | Hypokalemic Periodic Paralysis | Hypercalcemia | Stroke | Autoimmune Polyendocrine Syndrome | Nicotine Addiction | Contact Dermatitis | Epiphyseal Chondrodysplasia, Miura Type | Exfoliative Dermatitis | Familial Isolated Hyperparathyroidism | Acute Coronary Syndrome | Mandibuloacral Dysplasia With Type A Lipodystrophy | Fucosidosis | Borderline Personality Disorder | Arthrogryposis | Chudley-McCullough Syndrome | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Hydrocephalus | Low Tension Glaucoma | Cellulitis | Mountain Sickness | Cardiomyopathy, Dilated, 1L | Neurotoxicity | B-cell Chronic Lymphocytic Leukemia | Congenital Hereditary Endothelial Dystrophy Type I | Trichuriasis | Facioscapulohumeral Muscular Dystrophy Type 1 | Cold Agglutinin Disease | Hypoalbuminemia | Lymphoproliferative Disorders | Amish Infantile Epilepsy Syndrome | Vitelliform Macular Dystrophy | Myeloid Leukemia | Diabetes Insipidus | Paracoccidioidomycosis | Paraganglioma, Carotid Body | Giant Cell Arteritis | Protein S Deficiency | Nutrition Disorders | Esophageal Adenocarcinoma | Phenylketonuria | Epidermodysplasia Verruciformis | Kindler Syndrome | Hemolytic Anemia | Eczema | Intermittent Explosive Disorder | Congenital Hemolytic Anemia | Heterotopic Ossification | CHOPS Syndrome | Primrose Syndrome | Partington Syndrome | Paget's Disease Of The Breast | Anti-NMDA Receptor Encephalitis | Ventricular Septal Defect | Pneumothorax | Pemphigoid | Hyperlipidemia, Familial Combined | Intracerebral Hemorrhage | Primary Lateral Sclerosis | Goldenhar Syndrome | Asphyxia Neonatorum | Reflex Epilepsy | Nijmegen Breakage Syndrome | Poikiloderma With Neutropenia | Pathological Gambling | Focal Segmental Glomerulosclerosis | Corneal Dystrophy | Familial Retinal Arterial Macroaneurysm | Optic Atrophy 2 | Neuromyelitis Optica | Congenital Myasthenic Syndrome | Infantile Spasm | Cholestasis, Intrahepatic | Chromosome 16p11.2 Deletion Syndrome | Persistent Fetal Circulation | Ganglioglioma | Johanson-Blizzard Syndrome | Citrullinemia | 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