ACTH-independent Macronodular Adrenal Hyperplasia

About the Disease
Acth-Independent Macronodular Adrenal Hyperplasia, also known as adrenocorticotropic hormone-independent macronodular adrenal hyperplasia, is related to acth-independent macronodular adrenal hyperplasia 1 and premature ovarian failure 7, and has symptoms including agitation and generalized fatigue. An important gene associated with Acth-Independent Macronodular Adrenal Hyperplasia is GNAS (GNAS Complex Locus), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Racepinephrine and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, pituitary and skeletal muscle, and related phenotypes are macronodular adrenal hyperplasia and moon facies

Common Targets
CYP17A1 | CYP21A2 | STAR | CYP11A1 | CYP11B1 | PDE11A | CYP11B2 | ARMC5 | HSD3B1 | HSD3B2

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