Budd-Chiari Syndrome

About the Disease
Budd-Chiari Syndrome, also known as hepatic vein thrombosis, is related to esophageal varix and varicose veins. An important gene associated with Budd-Chiari Syndrome is JAK2 (Janus Kinase 2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Protein C and Atezolizumab have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and heart, and related phenotypes are splenomegaly and portal hypertension

Common Targets
PROC | MASP2 | F2 | MTHFR | F5 | JAK2

Note: If you'd like to get a target analysis report for Budd-Chiari Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Budd-Chiari Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Bietti Crystalline Dystrophy | Charcot-Marie-Tooth Disease, Type 2C | Geleophysic Dysplasia | Tardive Dyskinesia | Emery-Dreifuss Muscular Dystrophy | Guanidinoacetate Methyltransferase Deficiency | Osteochondroma | Onchocerciasis | Familial Mediterranean Fever | Noonan Syndrome | Acute Anterior Uveitis | Congenital Nystagmus | Fibromyalgia | Spinocerebellar Ataxia Type 42 | Stiff-man Syndrome | Ocular Albinism Type 1 | Primary Biliary Cholangitis | Microtia | Peters-plus Syndrome | Hypopituitarism | Hypothalamic Obesity | Pancytopenia | Familial Pheochromocytoma-paraganglioma | Autonomic Neuropathy | Spondylosis | Spinocerebellar Ataxia Type 6 | Chordoma | Chronic Kidney Disease | Esophagitis, Eosinophilic | Astrocytoma | Sclerosing Cholangitis | Potocki-Shaffer Syndrome | Proximal Symphalangism | Trichothiodystrophy | Transient Bullous Dermolysis Of The Newborn | Hemangioma | Hashimoto Thyroiditis | Pseudoexfoliation Syndrome | Bronchiolitis | Sarcoma, Endometrial Stromal | Rash | Diabetic Encephalopathy | Osteogenesis Imperfecta Type VI | Cholera | Encephalitis | PASLI Disease | Carcinoma In Situ | Cholelithiasis | Ichthyosis, X-linked | CHARGE Syndrome | Brachydactyly | Ileitis | CREST Syndrome | Diverticulitis | Holt-Oram Syndrome | Albinism | Brachial Plexus Neuropathy | Coloboma | Ameloblastoma | Chronic Mucocutaneous Candidiasis | Photosensitivity | Spinocerebellar Ataxia Type 8 | Amelanotic Melanoma | Angioedema | Whipple's Disease | Congenital Myopathy | Acral Lentiginous Melanoma | Acromicric Dysplasia | Hemochromatosis Type 1 | Otitis Externa | Thrombosis | Choroiditis | Optic Nerve Hypoplasia, Bilateral | Spinocerebellar Ataxia Type 28 | Cousin Syndrome | Sensorineural Hearing Loss | Specific Granule Deficiency | Marshall-Smith Syndrome | Hepatitis D | Chordoid Glioma | Dupuytren Disease | Raynaud Phenomenon | LRBA Deficiency | Liver Failure, Acute Infantile | Lipid Storage Diseases | Colorectal Adenoma | Membranous Nephropathy | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Autism | Malonyl-CoA Decarboxylase Deficiency | Influenza | Glycogen Storage Disease Type 1 | Macular Degeneration | Hypertensive Nephropathy | Pantothenate Kinase-associated Neurodegeneration | Tylosis With Esophageal Cancer | Schaaf-Yang Syndrome | Encephalopathy, Glycine | Esthesioneuroblastoma | Cocaine-Related Disorders | Bipolar Disorder | Spinocerebellar Ataxia Type 23 | Generalized Epilepsy And Paroxysmal Dyskinesia | Erysipelas | Enterocolitis, Necrotizing | Olmsted Syndrome | Phenylketonuria | Fontaine Progeroid Syndrome | Snyder-Robinson Syndrome | Hamartoma | Familial Thoracic Aortic Aneurysm | Schwannoma | Veno-occlusive Disease | Toxic Epidermal Necrolysis | Peripheral T-cell Lymphoma | Juvenile Xanthogranuloma | Keratopathy | Hyperbilirubinemia, Neonatal | Autosomal Recessive Congenital Ichthyosis | Pulverulent Zonular Cataract | Cervicitis | Glomerulonephritis, Membranous | Hepatitis | Spondylocostal Dysostosis | Persistent Truncus Arteriosus | Retinitis | Achromatopsia | Proteasome-associated Autoinflammatory Syndrome 2 | Schwannomatosis | Hydrocephalus | Poikiloderma With Neutropenia | Thyroid Dyshormonogenesis | Retinoblastoma | Restrictive Dermopathy | Mevalonate Kinase Deficiency | Gangliosidosis, GM1 | Congenital Heart Block | Stickler Syndrome | Familial Advanced Sleep Phase Syndrome | Schizophrenia, Paranoid | 3C Syndrome | Acute Lung Injury | Aldosterone Deficiency | Pyruvate Kinase Deficiency | Hepatic Adenomatosis | Hypotrichosis Simplex | Pouchitis | Stroke, Ischemic | Rotor Syndrome | Apparent Mineralocorticoid Excess Syndrome | Fabry's Disease | Cystinosis | Charcot-Marie-Tooth Disease Type 2T | Cardiospondylocarpofacial Syndrome | Conjunctivitis, Allergic | Erythematotelangiectatic Rosacea | Lattice Corneal Dystrophy Type 1 | Argininosuccinic Aciduria | Pseudomyxoma Peritonei | Barrett Esophagus | Panniculitis | Nicotine Dependence | Osteogenesis Imperfecta Type III | Diabetes Insipidus, Neurogenic | Congenital Bilateral Absence Of Vas Deferens | Hypophosphatasia | Glioblastoma | Moyamoya Disease | Dyslipidemia | Erythromelalgia | Unverricht-Lundborg Syndrome | CDKL5 Deficiency Disorder | Thalassemia, Beta | Precocious Puberty | Liddle Syndrome | Pure Autonomic Failure | Small Lymphocytic Lymphoma | Overactive Bladder | Leukemia | Congenital Diaphragmatic Hernia | Epilepsy Of Infancy With Migrating Focal Seizures | Hypersomnia | DICER1 Syndrome | Osteoporosis | Charcot-Marie-Tooth Disease Type 2E | Learning Disability | Early Infantile Epileptic Encephalopathy 1 | Hypobetalipoproteinemias | Allan-Herndon-Dudley Syndrome | Gangliosidosis | Trigonocephaly | Hypercholesterolemia, Familial | Charcot-Marie-Tooth Disease Type 3 | Gastrointestinal Disorders | Distal Myopathy | Platelet Disorders | Sclerosteosis | Thrombophlebitis | Exocrine Pancreatic Insufficiency | Syncope | HUPRA Syndrome | Vitamin B12 Deficiency | Malaria, Cerebral | Hypertension, Pulmonary | Autoimmune Autonomic Ganglionopathy | Left Ventricular Noncompaction | Hepatic Steatosis | Joubert Syndrome | Mycosis Fungoides | Apraxia | Paraganglioma | Histiocytic Sarcoma | Multicentric Carpotarsal Osteolysis Syndrome | Lipid Metabolism Disorders | Fibronectin Glomerulopathy | Neurodermatitis | Scoliosis | Congenital Dyserythropoietic Anemia Type 4 | Basal Ganglia Disease | Palsy, Cerebral | Retinitis Pigmentosa | Pulmonary Capillary Hemangiomatosis | Menetrier Disease | Okihiro Syndrome | Rhizomelic Chondrodysplasia Punctata | Hypercalciuria | Hermansky-Pudlak Syndrome | Stomatitis | Mitochondrial Encephalomyopathy | Chondroma | Headache | Hypermethioninemia | Blau Syndrome | Endometriosis | Nemaline Myopathy | Myositis | ICF Syndrome | Progressive Familial Intrahepatic Cholestasis | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Sarcoidosis | Varicocele | Sjogren Syndrome | Glioblastoma Multiforme | Pseudohypoaldosteronism | Cryopyrin-associated Periodic Syndromes | Blue Rubber Bleb Nevus Syndrome | Lentigo | Hairy Cell Leukemia | Thyroiditis | Tinea Versicolor | Peyronie's Disease | Tenosynovial Giant Cell Tumor | Basal Cell Nevus Syndrome | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Diffuse Palmoplantar Keratoderma | Colitis, Microscopic | Charcot-Marie-Tooth Disease Type 2D | Lupus Erythematosus | Situs Inversus | Infantile Nephropathic Cystinosis | Spinocerebellar Ataxia Type 10 | Weill-Marchesani Syndrome | Follicular Dendritic Cell Sarcoma | Multiple Hamartoma Syndrome | Retinitis Pigmentosa 3 | Pathological Gambling | Polycystic Ovary Syndrome | Central Pain Syndrome | Ganglioglioma | Renal Tubular Acidosis | Parkinsonism | Paronychia | Pilomatrix Carcinoma | Amelogenesis Imperfecta | Renal Hypouricemia | Hypereosinophilic Syndrome | Hyperinsulinism-hyperammonemia Syndrome | Psoriasis | Borderline Personality Disorder | Basal Ganglia Cerebrovascular Disease | Ureteropelvic Junction Obstruction | Nicotine Addiction | Glutaric Aciduria Type 3 | Spitzoid Melanoma | Osteosclerosis | Pterygium | Wolcott-Rallison Syndrome | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Williams Syndrome | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic | Mannosidase Deficiency Diseases | Arteriovenous Malformations | Hereditary Hemorrhagic Telangiectasia Type 2 | Otosclerosis | DiGeorge Syndrome | Chronic Myelomonocytic Leukemia | Cranioectodermal Dysplasia | Arthropathy | Osteogenesis Imperfecta Type V | Conduct Disorder | Wolfram Syndrome | Non-proliferative Diabetic Retinopathy | Heart Failure | Myofibromatosis | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | Neurofibromatosis Type 2 | Thin Basement Membrane Disease | Intermittent Explosive Disorder | Cancer, Bladder | Pericarditis | TARP Syndrome | Stevens-Johnson Syndrome | Optic Neuritis | Carbonic Anhydrase VA Deficiency | Primrose Syndrome | Dysthymia | Pierpont Syndrome | Primary Erythromelalgia | Meconium Ileus | Cerebellar Ataxia, Cayman Type | Hemolytic Uremic Syndrome | Alzheimer Disease, Late Onset | Polycythemia Vera | Adenomatoid Tumor | Transthyretin-related Amyloidosis | Deafness, Dystonia, And Cerebral Hypomyelination | Oligodendroglioma | Familial Retinal Arterial Macroaneurysm | Fuchs Heterochromic Iridocyclitis | Neurofibrosarcoma | Localized Scleroderma | Hydrocephalus, Normal Pressure | Beare-Stevenson Syndrome | Lassa Fever | Obsessive-compulsive Disorder | Adrenal Insufficiency | Cockayne Syndrome | Joubert Syndrome 2 | Adrenoleukodystrophy, X-linked | Blue Nevus | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Hepatitis, Chronic | Peripheral Neuropathy | Hernia, Inguinal | Goldenhar Syndrome | Esotropia | Stroke, Hemorrhagic | DNA Ligase IV Deficiency | Primary Aldosteronism | Loeys-Dietz Syndrome | Lathosterolosis | Gnathodiaphyseal Dysplasia | Atrioventricular Septal Defect | McLeod Syndrome | Metaphyseal Chondrodysplasia, Schmid Type | Takenouchi-Kosaki Syndrome | Pelizaeus-Merzbacher Disease | Arthritis, Gouty | Lactose Intolerance | Acrodysostosis | Immunoproliferative Disorders | Epidermal Nevus Syndrome | Neuromyotonia | Inborn Errors Of Metabolism | Pitt-Hopkins Syndrome | Erectile Dysfunction | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Trichomegaly | Intestinal Pseudo-obstruction | Globozoospermia | Hypoplastic Left Heart Syndrome | Hypertriglyceridemia | Filariasis | Orthostatic Intolerance | Gliosarcoma | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Presbyopia | Christianson Syndrome | Fibrosarcoma | Ganglioneuroma | Spinocerebellar Ataxia Type 15 | Primary Lateral Sclerosis | Analgesia | Blepharophimosis Syndrome | Uremia | Megaloblastic Anemia | Hypervalinemia | Gastritis, Atrophic | Hartnup Disease | Dementia | Gastroenteritis, Eosinophilic | Spinocerebellar Ataxia Type 20 | Diamond-Blackfan Anemia | Lymphoma, AIDS-related | Endocarditis | Angioedema, Acquired | Diabetes | Jacobsen Syndrome | Knobloch Syndrome