Budd-Chiari Syndrome

About the Disease
Budd-Chiari Syndrome, also known as hepatic vein thrombosis, is related to esophageal varix and varicose veins. An important gene associated with Budd-Chiari Syndrome is JAK2 (Janus Kinase 2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Protein C and Atezolizumab have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and heart, and related phenotypes are splenomegaly and portal hypertension

Common Targets
PROC | MASP2 | F2 | MTHFR | F5 | JAK2

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