Triphalangeal Thumb-polysyndactyly Syndrome

About the Disease
Polydactyly, Preaxial Ii, also known as polydactyly of a triphalangeal thumb, is related to triphalangeal thumb with polysyndactyly and colobomatous microphthalmia. An important gene associated with Polydactyly, Preaxial Ii is LMBR1 (Limb Development Membrane Protein 1), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Hedgehog signaling pathway. Affiliated tissues include bone, t cells and heart, and related phenotypes are preaxial hand polydactyly and opposable triphalangeal thumb

Common Targets
GLRB | FBXO8 | GRIA2 | LMBR1 | PDGFC

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