MELAS Syndrome

About the Disease
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes, also known as melas syndrome, is related to mitochondrial myopathy and lactic acidosis, and has symptoms including myalgia, hemiparesis and ophthalmoplegia. An important gene associated with Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes is MT-ND6 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6), and among its related pathways/superpathways are "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." and Complex I biogenesis. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and heart, and related phenotypes are eeg abnormality and muscle weakness

Common Targets
MAOA | TRNS1 | PTGS1 | G7295 | COX3 | G23411 | DNA Topoisomerase II (nonspecified subtype) | TRNW | CYTB | XDH | PTPN1 | PPARD | Mitogen-Activated Protein Kinase (nonspecified subtype) | SUCLG2 | DGUOK | SCO1 | POLG | NF-kappaB (NFkB) | NDUFAF6 | ND3 | KCNQ1 | TRNT1 | LOXHD1 | SCN5A | NQO1 | Soluble guanylyl cyclase | ND5 | MYH7 | TRNL1 | KCNQ2 | TRNL2 | Calcium channel (nonspecified subtype) | PPARA | G5243 | COX2

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Other Diseases

Stargardt Disease | Hydrocephalus, Normal Pressure | Combined Pituitary Hormone Deficiency | Aspartylglycosaminuria | Ocular Surface Squamous Neoplasia | Vitelliform Macular Dystrophy | Fundus Albipunctatus | Primary Carnitine Deficiency | Van Der Knaap Disease | Hypotension, Orthostatic | Myocardial Infarction | Anorectal Fistula | Congenital Hemolytic Anemia | Marshall-Smith Syndrome | Oligoasthenoteratozoospermia | Carcinoma In Situ | Bartsocas-Papas Syndrome | Acanthosis Nigricans | Congenital Adrenal Hyperplasia 1 | Barrett Esophagus | Choroiditis | Chronic Neutrophilic Leukemia | Torticollis | Rolandic Epilepsy | Hereditary Mixed Polyposis Syndrome | Leprosy | Acute Lymphocytic Leukemia | Aicardi-Goutieres Syndrome | Scleroderma, Diffuse | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Microphthalmia | Cholelithiasis | Fatty Aldehyde Dehydrogenase Deficiency | Androgen Insensitivity | Tendinitis | Uremia | Erythematotelangiectatic Rosacea | Charcot-Marie-Tooth Disease Type 4D | Hepatitis, Alcoholic | Stickler Syndrome | Hypertension, Essential | Tyrosinemia | Idiopathic Pulmonary Fibrosis | Eczema | Neurotoxicity | Renal Failure | Dyslexia | Orotic Aciduria | Alopecia Areata | HUPRA Syndrome | Chorioretinitis | Primary Lateral Sclerosis | Open-angle Glaucoma | Erectile Dysfunction | Cataplexy | Pouchitis | Raine Syndrome | Paraganglioma, Carotid Body | Anxiety Disorders | Rhinitis | Obesity | Carcinoma, Merkel Cell | Antithrombin III Deficiency | Pseudoexfoliation Syndrome | Anorexia Nervosa | Tonsillitis | Pierson Syndrome | Abetalipoproteinemia | Hypolipoproteinemia | Lymphoma Lymphoblastic | Gitelman Syndrome | Trichomegaly | Rheumatic Heart Disease | Nemaline Myopathy 8 | Carney-Stratakis Syndrome | Shprintzen-Goldberg Syndrome | Cancer, Prostate | Distal Myopathy | Thalassemia | Sickle Cell Disease | Desmosterolosis | Tibial Muscular Dystrophy | Hepatitis C, Chronic | Plasmacytoma | Acne Vulgaris | Spondylo-ocular Syndrome | Osteogenesis Imperfecta | Central Pain Syndrome | Sandhoff Disease | Alpha-thalassemia Myelodysplasia Syndrome | Aldosteronism | Diamond-Blackfan Anemia | Urolithiasis | Progressive Encephalopathy-optic Atrophy Syndrome | Vitamin B12 Deficiency | Treacher Collins Syndrome | Porphyria | Klinefelter Syndrome | Hereditary Hemorrhagic Telangiectasia Type 2 | Erdheim-Chester Disease | Disseminated Intravascular Coagulation | Intestinal Tuberculosis | Diabetic Nephropathy | Adenomatoid Tumor | Giant Cell Glioblastoma | Hemoglobinopathies | Congenital Myasthenic Syndrome | SAPHO Syndrome | Glycogen Storage Disease Type 3 | PASLI Disease | Temtamy Preaxial Brachydactyly Syndrome | CDKL5 Deficiency Disorder | Crouzon Syndrome With Acanthosis Nigricans | Pulmonary Veno-occlusive Disease | NDH Syndrome | Diabetic Neuropathy | Oculocutaneous Albinism | Distal Spinal Muscular Atrophy | Colitis, Microscopic | Schwannoma | Saul-Wilson Syndrome | Hypothyroidism | Necrobiosis Lipoidica | Stevens-Johnson Syndrome | Osteomyelitis | Congenital Diaphragmatic Hernia | Sensorineural Hearing Loss | Hamartoma | Spinocerebellar Ataxia Type 16 | Chiari Malformation Type I | Fontaine Progeroid Syndrome | Congenital Hypofibrinogenemia | Arts Syndrome | Schistosomiasis | Epidermolysis Bullosa Simplex With Mottled Pigmentation | Metatropic Dysplasia | Fibrosarcoma | Sclerosing Cholangitis | Roberts Syndrome | Irritable Bowel Syndrome | Myotonia | Basal Cell Nevus Syndrome | Pulmonary Capillary Hemangiomatosis | Erythromelalgia | Hypothalamic Obesity | Heart Septal Defects | Sarcosinemia | Netherton Syndrome | Alexander Disease | Pyoderma Gangrenosum | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Lafora Disease | Diabetic Encephalopathy | Familial Advanced Sleep Phase Syndrome | Moyamoya Disease | Tetraplegia | Lymphopenia | Panniculitis | Leukocyte Adhesion Deficiency Type 1 | Best Macular Dystrophy | Retinitis | Personality Disorders | Antiphospholipid Syndrome | Hyperparathyroidism-jaw Tumor Syndrome | Blepharophimosis Syndrome | Brachydactyly | Ocular Hypertension | Epicondylitis | Hydrops Fetalis | Mosaic Variegated Aneuploidy Syndrome 2 | Acute Lung Injury | Muscular Dystrophy | Bladder Exstrophy | Greig Cephalopolysyndactyly Syndrome | Leishmaniasis, Cutaneous | Cocaine-Related Disorders | Familial Hyperaldosteronism | Spinocerebellar Ataxia Type 40 | Spinocerebellar Ataxia Type 14 | Cherubism | Autism | Trigonocephaly | Ventricular Septal Defect | Carcinoma, Signet Ring Cell | Angiosarcoma Of The Breast | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Asphyxia Neonatorum | Brenner Tumor | Episodic Ataxia | Carotid Artery Disease | Craniofacial Dysostosis | Scoliosis | Renal Tubular Acidosis | Fetal Alcohol Syndrome | Hypertension, Renal | Macrophagic Myofasciitis | Retinal Dystrophy, Early-onset Severe | Wilson's Disease | Epilepsy, Generalized | Osteosarcoma | Angioedema | Isobutyryl-CoA Dehydrogenase Deficiency | Silver-Russell Syndrome | Cole-Carpenter Syndrome | Li-Fraumeni Syndrome | Fuchs Dystrophy | Congenital Adrenal Hyperplasia | Miyoshi Myopathy | Osteochondroma | Kawasaki Disease | Diffuse Palmoplantar Keratoderma | Ureteropelvic Junction Obstruction | Hypobetalipoproteinemias | Granular Corneal Dystrophy Type 1 | Infectious Diarrhea | Primary Ovarian Insufficiency | Duchenne Muscular Dystrophy | Hyperostosis | Charcot-Marie-Tooth Disease, Type 2C | Nijmegen Breakage Syndrome | Mucolipidosis Type III | Dubin-Johnson Syndrome | Shwachman-Bodian-Diamond Syndrome | Primrose Syndrome | Carcinoid Syndrome | Gingivitis | Congenital Poikiloderma | Ovarian Sex Cord-stromal Tumor | Globozoospermia | Adenoid Cystic Carcinoma | Ophthalmoplegia | Reticular Dysgenesis | Erythrokeratodermia Variabilis | Mandibuloacral Dysplasia With Type A Lipodystrophy | Pancytopenia | Purpura, Thrombotic Thrombocytopenic | Recurrent Respiratory Papillomatosis | Trichorhinophalangeal Syndrome | Primary Progressive Nonfluent Aphasia | Progressive Osseous Heteroplasia | Alopecia Totalis | Congenital Tufting Enteropathy | Pseudo-pseudohypoparathyroidism | Actinomycetoma | Atelosteogenesis Type 1 | Narcolepsy | Intracranial Hypertension | Cutis Laxa | DRESS Syndrome | Melanoma, Malignant | Colitis | Sickle Cell Anemia | Nicotine Dependence | Danon Disease | Dyggve-Melchior-Clausen Disease | Mountain Sickness | Acquired Partial Lipodystrophy | Hyperlipidemia, Familial Combined | Isovaleric Acidemia | Corneal Neovascularization | Lyme Disease | Pneumonia, Bacterial | Spinocerebellar Ataxia Type 3 | Botulism | Graves Disease | Presbycusis | Congenital Myopathy | Bipolar Disorder | Familial Mediterranean Fever | Exocrine Pancreatic Insufficiency | Congenital Absence Of Vas Deferens | Gastric Atrophy | Hemophilia | Majeed Syndrome | Generalized Epilepsy With Febrile Seizures Plus | Histoplasmosis | Acute Anterior Uveitis | Diabetes Type 2 | Chylomicron Retention Disease | Glutaric Aciduria Type 2 | Multisystemic Smooth Muscle Dysfunction Syndrome | Waardenburg Syndrome Type 2 | Rubinstein-Taybi Syndrome | Retinitis Pigmentosa 3 | Pilomatrix Carcinoma | Osteosclerosis | Castleman Disease | Autosomal Recessive Spastic Paraplegia Type 54 | Pontocerebellar Hypoplasia | Retinoblastoma | Mevalonate Kinase Deficiency | Spinocerebellar Ataxia Type 1 | Tylosis With Esophageal Cancer | Albinism | Hypoplastic Left Heart Syndrome | Amish Infantile Epilepsy Syndrome | Cockayne Syndrome | Microcephaly, Seizures, And Developmental Delay | Hemorrhoids | Spinocerebellar Ataxia Type 28 | 3-methylglutaconic Aciduria Type I | Bacterial Meningitis | Exostoses | Asthma, Exercise-induced | Neuronal Ceroid Lipofuscinosis | Binge Eating Disorder | Holt-Oram Syndrome | Carcinoma, Transitional Cell | Restless Legs Syndrome | Anodontia | Diabetes Insipidus, Neurogenic | Coronary Artery Disease | Periventricular Nodular Heterotopia | Hyperthermia, Malignant | Corneal Dystrophies, Hereditary | Mesothelioma, Malignant | Nager Acrofacial Dysostosis | Spondyloepiphyseal Dysplasia Tarda, X-linked | Epilepsy | Myocarditis | Craniofrontonasal Syndrome | Usher Syndrome Type I | Acrodermatitis | Cholestasis, Intrahepatic | Parkinson Disease 6, Autosomal Recessive Early-onset | Thalassemia, Beta | Heart Failure | Hemochromatosis Type 2 | Colorectal Adenoma | Autoimmune Hemolytic Anemia | Intermittent Claudication | Neurofibromatosis | Hyperparathyroidism | Chronic Myelomonocytic Leukemia | Necrotizing Autoimmune Myopathy | Sarcoma, Endometrial Stromal | Cholestasis | Pneumococcal Meningitis | Iron Deficiency Anemia | Fibromuscular Dysplasia | Graft-versus-host Disease | Rothmund-Thomson Syndrome | Intracerebral Hemorrhage | Congestive Heart Failure | Purpura | Celiac Disease | Adenomyosis | Alpha-1 Antitrypsin Deficiency | Leukocyte Adhesion Deficiency | Glycogen Storage Disease Type 1 | Currarino Syndrome | Osteoglophonic Dysplasia | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Smith-Magenis Syndrome | Priapism | Persistent Mullerian Duct Syndrome | Language Disorders | Chordoma | Neurodevelopmental Disorders | Incontinentia Pigmenti | Polycystic Ovary Syndrome | Herpes Simplex Dermatitis | Snyder-Robinson Syndrome | Martsolf Syndrome | Galloway-Mowat Syndrome | Polydactyly | Leigh Syndrome | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Succinic Semialdehyde Dehydrogenase Deficiency | Camurati-Engelmann Disease | Meier-Gorlin Syndrome | Retinoschisis | VEXAS Syndrome | Glycogen Storage Disease Type 1a | REM Sleep Behavior Disorder | Idiopathic Multicentric Castleman Disease | Prostatitis | Blepharospasm | Light Chain Amyloidosis | Cabezas Syndrome | Kaposi Sarcoma | Osteogenesis Imperfecta Type VI | Christianson Syndrome | Spitz Nevus | Prolidase Deficiency | Peroxisomal Disorder | Cushing Syndrome | Common Variable Immunodeficiency | Apraxia | Crigler-Najjar Syndrome | Cryptorchidism | Megalencephaly | Compartment Syndrome | Pineoblastoma | Saethre-Chotzen Syndrome | Schindler Disease | Addison Disease | Tatton-Brown-Rahman Syndrome | Dermatofibrosarcoma | Nephronophthisis