MELAS Syndrome

About the Disease
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes, also known as melas syndrome, is related to mitochondrial myopathy and lactic acidosis, and has symptoms including myalgia, hemiparesis and ophthalmoplegia. An important gene associated with Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes is MT-ND6 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6), and among its related pathways/superpathways are "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." and Complex I biogenesis. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and heart, and related phenotypes are eeg abnormality and muscle weakness

Common Targets
MAOA | TRNS1 | PTGS1 | G7295 | COX3 | G23411 | DNA Topoisomerase II (nonspecified subtype) | TRNW | CYTB | XDH | PTPN1 | PPARD | Mitogen-Activated Protein Kinase (nonspecified subtype) | SUCLG2 | DGUOK | SCO1 | POLG | NF-kappaB (NFkB) | NDUFAF6 | ND3 | KCNQ1 | TRNT1 | LOXHD1 | SCN5A | NQO1 | Soluble guanylyl cyclase | ND5 | MYH7 | TRNL1 | KCNQ2 | TRNL2 | Calcium channel (nonspecified subtype) | PPARA | G5243 | COX2

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Other Diseases

Hereditary Xerocytosis | Hemophagocytic Lymphohistiocytosis | Nicotine Dependence | Hypokalemia | Mitochondrial Cytopathy | Pontocerebellar Hypoplasia Type 7 | Coronary Artery Disease | Hyperprolactinemia | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Spinocerebellar Ataxia Type 13 | Primary Torsion Dystonia | Dentinogenesis Imperfecta | Pyruvate Dehydrogenase Deficiency | Myhre Syndrome | Esophageal Adenocarcinoma | Spinal Muscular Atrophy | Lyme Disease | Oligoasthenoteratozoospermia | Cryptococcal Meningitis | Peeling Skin Syndrome Type B | Erdheim-Chester Disease | Osteoarthritis | Mosaic Variegated Aneuploidy Syndrome 2 | Osteonecrosis Of The Jaw | Pneumoconiosis | Hartnup Disease | Mucolipidosis | Alveolar Capillary Dysplasia | Premenstrual Syndrome | Platelet Disorders | Alpha-1 Antitrypsin Deficiency | Pachyonychia Congenita | Histiocytosis | Primary Pigmented Nodular Adrenocortical Disease | Cerebrotendinous Xanthomatosis | Microcephaly, Seizures, And Developmental Delay | Tietze Syndrome | Optic Atrophy 2 | Vitamin A Deficiency | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Homocystinuria | Fascioliasis | Keratitis-ichthyosis-deafness Syndrome | Kaposiform Hemangioendothelioma | Hepatic Adenomatosis | Primary Hyperoxaluria Type 3 | Glutaric Aciduria Type 1 | Hypermethioninemia | Lymphangioleiomyomatosis | Ectopia Lentis, Isolated, Autosomal Recessive | Erysipelas | Hemolytic Anemia | Transthyretin-related Amyloidosis | Cat Eye Syndrome | Blepharo-cheilo-odontic Syndrome | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | ADNP Syndrome | Coronary Restenosis | Milk Allergy | Ollier Disease | Adenoma, Villous | Fabry's Disease | Twin-to-twin Transfusion Syndrome | Multicystic Renal Dysplasia | Small Lymphocytic Lymphoma | Waardenburg Syndrome Type 1 | Sickle Cell Anemia | Transient Bullous Dermolysis Of The Newborn | Addison Disease | Granular Corneal Dystrophy | Takotsubo Cardiomyopathy | Neurocutaneous Syndromes | Thyroid Dysgenesis | Osteochondrosis | Spondylo-ocular Syndrome | Skin Fragility-woolly Hair Syndrome | Spitz Nevus | Osteosarcoma | Ehlers-Danlos Syndrome | Cholangiocarcinoma | Amyotrophic Lateral Sclerosis, Juvenile | Optic Nerve Hypoplasia, Bilateral | Multisystemic Smooth Muscle Dysfunction Syndrome | Overactive Bladder | Megaloblastic Anemia | Reflex Epilepsy | Bipolar Disorder | Glycogen Storage Disease Type 1 | Epilepsy Of Infancy With Migrating Focal Seizures | Vitelliform Macular Dystrophy | Chromosome 5q Deletion Syndrome | Spinocerebellar Ataxia Type 6 | Proopiomelanocortin Deficiency | Giant Cell Glioblastoma | Congenital Bilateral Absence Of Vas Deferens | Marinesco-Sjogren Syndrome | Nail-Patella Syndrome | Rubeosis Iridis | Hennekam Lymphangiectasia-lymphedema Syndrome | Hemolytic Uremic Syndrome | Sulfite Oxidase Deficiency | Motor Neuron Diseases | Menkes Disease | Panniculitis | Endometriosis | Pigment Dispersion Syndrome | X-linked Acrogigantism | Multiple Sclerosis, Chronic Progressive | Rett Syndrome | Angiosarcoma Of The Breast | Acute Motor Axonal Neuropathy | Glycogen Storage Disease Type 9 | Hyperferritinemia-cataract Syndrome | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Paraganglioma | Gray Platelet Syndrome | Myelomeningocele | Stomatitis | Plasma Cell Leukemia | Clouston Hidrotic Ectodermal Dysplasia | Pyruvate Carboxylase Deficiency Disease | Keloid | Pseudohypoparathyroidism Type 1B | Hyperlipidemia, Familial Combined | Dwarfism | Kearns-Sayre Syndrome | Neuromuscular Disorders | Hypertension, Essential | Atelosteogenesis Type 2 | Cornelia De Lange Syndrome | Cherubism | Corneal Dystrophy And Perceptive Deafness | Desmosterolosis | Meningococcal Meningitis | Lafora Disease | B-cell Chronic Lymphocytic Leukemia | Amish Infantile Epilepsy Syndrome | Coenzyme Q10 Deficiency | Intellectual Disability, Autosomal Dominant 5 | Hemorrhagic Disorders | Ventricular Septal Defect | Heterotopic Ossification | 5-oxoprolinase Deficiency | Zygomycosis | Neurofibroma, Plexiform | Erythematotelangiectatic Rosacea | Macrophage Activation Syndrome | Anthrax | Hermansky-Pudlak Syndrome | Neonatal Progeroid Syndrome | Waardenburg Syndrome | Heroin Dependence | Chronic Idiopathic Myelofibrosis | Hypokalemic Periodic Paralysis | Loeys-Dietz Syndrome | Methylmalonic Acidemia | Hemimegalencephaly | Hypotonia-cystinuria Syndrome | ICF Syndrome | Alzheimer Disease, Late Onset | Epidermolysis Bullosa Simplex, Localized | Niemann-Pick Disease, Type C | Chronic Inflammatory Demyelinating Polyneuropathy | Primary Erythromelalgia | Blood Protein Disorders | Spinocerebellar Ataxia Type 27 | SAPHO Syndrome | Malnutrition | Chondrodysplasia Punctata 1, X-linked Recessive | Inflammatory Myopathy | Joubert Syndrome | Purpura | Benign Familial Pemphigus | Epilepsy | Partington Syndrome | Eclampsia | Paraganglioma, Carotid Body | GNE Myopathy | Hypohidrotic Ectodermal Dysplasia | Shwachman-Bodian-Diamond Syndrome | Guillain-Barre Syndrome | Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Form | Ulcerative Colitis | Necrotizing Autoimmune Myopathy | Esophageal Motility Disorders | Hereditary Multiple Exostoses | Seizures | Autoimmune Polyendocrinopathy Syndrome Type I | Tenosynovial Giant Cell Tumor | Cardiac Arrest | Hydrops Fetalis | Kabuki Syndrome | Adenoma, Pleomorphic | Diarrhea | Adenomyosis | Poretti-Boltshauser Syndrome | Leber Congenital Amaurosis | Cushing Syndrome | Sleep Apnea | Microtia | Syndactyly | Agnathia-Otocephaly Complex | Diabetic Neuropathy | Localized Scleroderma | Pineoblastoma | Ataxia-hypogonadism-choroidal Dystrophy Syndrome | Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia | Treacher Collins Syndrome | Autosomal Recessive Spastic Paraplegia Type 54 | Osteopetrosis | Spondyloepiphyseal Dysplasia Tarda, X-linked | Arthropathy | Primary Familial Brain Calcification | Dyskeratosis Congenita | Conduct Disorder | Primary Sclerosing Cholangitis | Myeloid Leukemia | Colitis | Lewy Body Dementia | Myocardial Infarction | Bullous Pemphigoid | Greig Cephalopolysyndactyly Syndrome | Conjunctivitis, Allergic | Glycogen Storage Disease Type 1b | Cervicitis | Angioedema, Acquired | Primary Carnitine Deficiency | Keratoconus | Glucagonoma | Tinea | Neurogenic Bladder | Osteoglophonic Dysplasia | Sialidosis Type I | Cerebellar Ataxia, Cayman Type | Craniopharyngioma | Otitis Media | Polyomavirus Nephropathy | Dysfibrinogenemia | Creatine Deficiency Syndrome | Raynaud Phenomenon | Trimethylaminuria | Congenital Nystagmus | Polyneuropathy | Leukocyte Adhesion Deficiency | Myelofibrosis | Meningioma | Weill-Marchesani Syndrome | Wagner Disease | Supravalvular Aortic Stenosis | Hypodontia | Erythrokeratodermia Variabilis | Chylomicron Retention Disease | Arrhythmogenic Right Ventricular Cardiomyopathy | Reye Syndrome | Galactosialidosis | Schaaf-Yang Syndrome | Syncope | Epidermolysis Bullosa Dystrophica | Schizophrenia, Paranoid | Diabetes Gestational | Eczema | Cardiospondylocarpofacial Syndrome | Mucormycosis | Viral Meningitis | Neuromyotonia | Protein C Deficiency | Pyloric Stenosis, Infantile Hypertrophic | Cheilitis | Cervical Dystonia | Retinitis Pigmentosa | Urofacial Syndrome | Vitreoretinal Degeneration, Snowflake Type | Toxic Epidermal Necrolysis | Lymphangioma | Alopecia Totalis | Neuromyelitis Optica | Cenani-Lenz Syndactyly Syndrome | Polycystic Ovary Syndrome | Fibromyalgia | Multiple Sclerosis, Relapsing-remitting | Shprintzen-Goldberg Syndrome | VACTERL/VATER Association | Porphyria Cutanea Tarda | Gestational Trophoblastic Disease | Scleritis | Triphalangeal Thumb-polysyndactyly Syndrome | Multiple System Atrophy | Congestive Heart Failure | Porencephaly | Spinocerebellar Ataxia Type 23 | Peyronie's Disease | Antisocial Personality Disorder | Familial Hemiplegic Migraine | McLeod Syndrome | Double Outlet Right Ventricle | Wolfram Syndrome 2 | Choroiditis | Focal Dermal Hypoplasia | Globozoospermia | Diffuse Intrinsic Pontine Glioma | Placenta Previa | Carotid Artery Disease | Cranial Nerve Disease | Blepharitis | Pituitary Stalk Interruption Syndrome | Gangliosidosis | Hydrocephalus | Pompe Disease | Ischemia | Norrie Disease | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Hypertelorism | Neuroma | Ligneous Conjunctivitis | Branchiootorenal Syndrome | Vici Syndrome | Noonan Syndrome | Toxoplasmosis | Plasma Cell Dyscrasia | Diabetes Insipidus, Nephrogenic | Alpha-mannosidosis | Hypercholesterolemia, Familial | Bronchiolitis | Neuronal Ceroid Lipofuscinosis | Contact Dermatitis | Lymphedema | Arteriovenous Malformations | Glutaric Aciduria Type 3 | Muir-Torre Syndrome | Renal Dysplasia | Hemochromatosis Type 2 | Osteogenesis Imperfecta Type IV | Lesch-Nyhan Syndrome | Primary Ovarian Insufficiency | Congenital Adrenal Hyperplasia | Autosomal Recessive Spastic Paraplegia Type 75 | Atopic Dermatitis | Infantile Refsum Disease | Dental Caries | Congenital Hereditary Endothelial Dystrophy Type I | Proteus Syndrome | Behavioral Variant Of Frontotemporal Dementia | Primary Hyperoxaluria | Prader-Willi Syndrome | 3-methylglutaconic Aciduria Type I | Acute Anterior Uveitis | Diverticulitis | Hyper IgE Syndrome | Rheumatoid Arthritis | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Spondylo-megaepiphyseal-metaphyseal Dysplasia | Histiocytic Sarcoma | Neurofibromatosis Type 1 | Protein S Deficiency | Alpha-thalassemia Myelodysplasia Syndrome | Eccrine Porocarcinoma | Barakat Syndrome | Hemangioblastoma | Hypobetalipoproteinemias | Osmotic Demyelination Syndrome | Retinopathy Of Prematurity | Communication Disorders | Fatty Aldehyde Dehydrogenase Deficiency | Alexander Disease | Glomerulonephritis, Membranous | Autism | Frontometaphyseal Dysplasia | Maternally Inherited Diabetes And Deafness | Central Pain Syndrome | Otosclerosis | Geleophysic Dysplasia | Erectile Dysfunction | Myoclonic Atonic Epilepsy | Trichomegaly | Cryoglobulinemia | Cardiomyopathy, Peripartum | Gastritis, Atrophic | Leri Pleonosteosis | Triple A Syndrome | Adrenoleukodystrophy, X-linked | Hydronephrosis | Fuchs Dystrophy | Congenital Poikiloderma | Charcot-Marie-Tooth Disease, Type 1A | Pseudomyxoma Peritonei | LMNA-related Congenital Muscular Dystrophy | Whipple's Disease | Amelanotic Melanoma | C3 Glomerulopathy | Colitis, Microscopic | Benign Familial Infantile Seizures | Trichotillomania | Xeroderma Pigmentosum | POEMS Syndrome | Hyperkeratosis | Sick Sinus Syndrome | Blastoma, Pleuropulmonary | Eiken Syndrome | Seizures-scoliosis-macrocephaly Syndrome | Cardiofaciocutaneous Syndrome