Disease

MELAS Syndrome

About the Disease
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes, also known as melas syndrome, is related to mitochondrial myopathy and lactic acidosis, and has symptoms including myalgia, hemiparesis and ophthalmoplegia. An important gene associated with Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes is MT-ND6 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6), and among its related pathways/superpathways are "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." and Complex I biogenesis. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and heart, and related phenotypes are eeg abnormality and muscle weakness

Common Targets
MAOA | TRNS1 | PTGS1 | G7295 | COX3 | G23411 | DNA Topoisomerase II (nonspecified subtype) | TRNW | CYTB | XDH | PTPN1 | PPARD | Mitogen-Activated Protein Kinase (nonspecified subtype) | SUCLG2 | DGUOK | SCO1 | POLG | NF-kappaB (NFkB) | NDUFAF6 | ND3 | KCNQ1 | TRNT1 | LOXHD1 | SCN5A | NQO1 | Soluble guanylyl cyclase | ND5 | MYH7 | TRNL1 | KCNQ2 | TRNL2 | Calcium channel (nonspecified subtype) | PPARA | G5243 | COX2

疾病靶点研报
MELAS Syndrome

Note: If you'd like to get a target analysis report for MELAS Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of MELAS Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Paternal Uniparental Disomy Of Chromosome 14 | Anorexia Nervosa | Methylmalonic Aciduria And Homocystinuria, CblC Type | MELAS Syndrome | Ependymoma | Pemphigus Vulgaris | Neurocutaneous Syndromes | Dementia, Vascular | Retinal Dystrophy | Genee-Wiedemann Syndrome | Keratitis-ichthyosis-deafness Syndrome | Hypercalcemia | Cholestasis, Intrahepatic | Thyroid Dyshormonogenesis | Progressive Osseous Heteroplasia | Chronic Myelomonocytic Leukemia | Hypermetropia | Pontocerebellar Hypoplasia Type 2 | Leiomyoma | Bacterial Meningitis | Moyamoya Disease | Chondroma | Frontotemporal Dementia With Amyotrophic Lateral Sclerosis | Familial Mediterranean Fever | Huntington's Disease-like 2 | Autoimmune Polyendocrinopathy Syndrome Type I | Craniolenticulosutural Dysplasia | Hereditary Inclusion Body Myopathy | Hemochromatosis Type 1 | Pure Red Cell Aplasia | Acute Lymphocytic Leukemia | Familial Advanced Sleep Phase Syndrome | Hermansky-Pudlak Syndrome | Hypobetalipoproteinemias | Premature Ejaculation | Cardiac Sarcoidosis | Wilson's Disease | Robinow Syndrome | Dermatitis Herpetiformis | Pain | Lymphedema | Lewy Body Dementia | Diabetes Gestational | TARP Syndrome | Central Retinal Artery Occlusion | Pitt-Hopkins Syndrome | Herpes Genitalis | Lissencephaly 2 | Beta-Propeller Protein-associated Neurodegeneration | Tetanus | Osteogenesis Imperfecta Type II | Chromosome 5q Deletion Syndrome | Hypertension, Portal | Pfeiffer Syndrome | Diamond-Blackfan Anemia | Cancer, Lung | Androgen Insensitivity | Fibromuscular Dysplasia | Nephronophthisis | Asthma, Exercise-induced | Pyruvate Kinase Deficiency | Primary Sclerosing Cholangitis | Cat Eye Syndrome | Hydronephrosis | Tay-Sachs Disease | Distal Myopathy | Pituitary Dwarfism | Esotropia | Congenital Adrenal Hyperplasia | Waardenburg Syndrome Type 4 | Achromatopsia | Cervical Dystonia | Periodontitis | C3 Glomerulopathy | Transcobalamin Deficiency | Dementia | Citrullinemia | Malnutrition | Gitelman Syndrome | Sleep Apnea | Retinal Coloboma | Centronuclear Myopathy | Cholera | Lysosomal Acid Lipase Deficiency | Ectopia Lentis, Isolated, Autosomal Recessive | Antiphospholipid Syndrome | Thin Basement Membrane Disease | Intestinal Hypomagnesemia 1 | Lattice Corneal Dystrophy Type 1 | Compartment Syndrome | Mucolipidosis | Kidney Stones | Combined Deficiency Of Factor V And Factor VIII | Angioedema | Spinal Muscular Atrophy Type 2 | Pseudoexfoliation Syndrome | Melnick-Needles Syndrome | Kohlschutter-Tonz Syndrome | Dermatitis | Aspergillosis | Epiphyseal Chondrodysplasia, Miura Type | Stuve-Wiedemann Syndrome | Heterotopic Ossification | Spondylo-ocular Syndrome | Irritable Bowel Syndrome | Antisocial Personality Disorder | Gastroenteritis, Eosinophilic | Senior-Loken Syndrome | Neurofibromatosis Type 2 | Optic Neuropathy | Sertoli Cell-only Syndrome | 3-hydroxy-3-methylglutaric Aciduria | Spinal Muscular Atrophy | Myofibrillar Myopathy | Esophagitis | Pre-eclampsia | DICER1 Syndrome | Hypohidrotic Ectodermal Dysplasia | Sialidosis Type I | Ocular Hypertension | Pineoblastoma | Roberts Syndrome | Charcot-Marie-Tooth Disease Type 4 | Paraplegia | Glioblastoma Multiforme | Thrombasthenia | Bone Giant Cell Tumor | Liver Diseases | Poikiloderma With Neutropenia | Hemorrhagic Disorders | MIRAGE Syndrome | Spinal Muscular Atrophy Type 3 | Rotor Syndrome | Spondylocarpotarsal Synostosis Syndrome | Triphalangeal Thumb-polysyndactyly Syndrome | Fraser Syndrome | Autism | Waardenburg Syndrome Type 4A | Lymphangioleiomyomatosis | Cancer, Brain | Hypotonia-cystinuria Syndrome | Myelitis, Transverse | Restrictive Dermopathy | Sarcoma, Alveolar Soft Part | Hyperlipidemia Type V | Vestibular Disease | Ectodermal Dysplasia | Acute Leukemia | Hydrops Fetalis | Depression | Nephropathy | Hereditary Multiple Exostoses | Prolactinoma | Spastic Paraplegia Type 7 | Chylothorax, Congenital | Peripheral Neuropathy | Retinitis Pigmentosa | Chronic Enteropathy Associated With SLCO2A1 Gene | Burn-McKeown Syndrome | Neuromyotonia | Primary Pigmented Nodular Adrenocortical Disease | Multicystic Renal Dysplasia | Scapuloperoneal Myopathy, X-linked Dominant | Early Infantile Epileptic Encephalopathy 13 | Premenstrual Syndrome | Thrombotic Microangiopathy | Inflammatory Joint Disease | Muscular Dystrophy | Intestinal Tuberculosis | Tremor | Osteonecrosis Of The Jaw | Primary Cutaneous Amyloidosis | Sjogren Syndrome | Galactosialidosis | Pityriasis Rubra Pilaris | Kabuki Syndrome | Cushing Syndrome | Ileitis | Peutz-Jeghers Syndrome | Histiocytic Sarcoma | ICF Syndrome | Azoospermia | Porokeratosis | Adenylosuccinate Lyase Deficiency | Impetigo | Hepatitis | Pupil Disorders | Paraganglioma, Carotid Body | Anencephaly | Temtamy Preaxial Brachydactyly Syndrome | Hydrocephalus | Neurocutaneous Melanocytosis | Axenfeld-Rieger Syndrome | VEXAS Syndrome | Cysticercosis | Proteus Syndrome | Leukodystrophies | Spinocerebellar Ataxia Type 20 | Creatine Deficiency Syndrome | Best Macular Dystrophy | Fukuyama Congenital Muscular Dystrophy | Meckel-Gruber Syndrome | Polyarteritis Nodosa | Hypoparathyroidism | Parvovirus B19 Infection | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Panniculitis | Alpers Syndrome | Dysgerminoma | Vici Syndrome | Empyema | Delirium | Acromesomelic Dysplasia | Gigantism | Cri-du-chat Syndrome | Congenital Lipoid Adrenal Hyperplasia | Cantu Syndrome | Schistosomiasis | Pseudomyxoma Peritonei | Netherton Syndrome | Deafness, Dystonia, And Cerebral Hypomyelination | Creatine Deficiency Syndrome Due To AGAT Deficiency | Hypophosphatemic Rickets With Hypercalciuria, Hereditary | Weill-Marchesani Syndrome | Pierpont Syndrome | Lymphoma, B-cell | Keratoconjunctivitis | Conjunctivitis | Pituitary Disorders | Schizoaffective Disorder | Fanconi Syndrome | Medulloblastoma | Diabetic Encephalopathy | Renal Hypouricemia | Hypercalciuria | Ectrodactyly | Distal Myopathy 2 | Hypotrichosis Simplex | Bulimia Nervosa | Central Core Disease | X-linked Creatine Transporter Deficiency | Trichuriasis | Branchiootorenal Syndrome | Xeroderma Pigmentosum | Autoimmune Autonomic Ganglionopathy | Angiomyolipoma | Spondyloepiphyseal Dysplasia Tarda, X-linked | Familial Hemiplegic Migraine | Autosomal Recessive Spastic Paraplegia Type 35 | Cone Dystrophy | Wolman Disease | Crouzon Syndrome With Acanthosis Nigricans | Raynaud Phenomenon | Emery-Dreifuss Muscular Dystrophy | Papillon-Lefevre Syndrome | Rosacea | Hypoglycemia | Autoimmune Hemolytic Anemia | Sarcoidosis, Pulmonary | Chondrodysplasia Punctata 2, X-linked Dominant | Fascioliasis | Hyperparathyroidism, Primary | Alopecia | Osmotic Demyelination Syndrome | Paroxysmal Nocturnal Hemoglobinuria | Chiari Malformation Type I | Heterotaxy | Metanephric Adenoma | Schuurs-Hoeijmakers Syndrome | Light Chain Amyloidosis | Pneumonia, Bacterial | Osteomyelitis | Glaucoma, Congenital | Retinitis | Dengue Hemorrhagic Fever | Cenani-Lenz Syndactyly Syndrome | Endometritis | Occipital Neuralgia | Partington Syndrome | Chromosome 16p11.2 Deletion Syndrome | Encephalopathy, Ethylmalonic | Conduct Disorder | Choroiditis | Hypogonadism | Learning Disability | Fibronectin Glomerulopathy | Pontocerebellar Hypoplasia Type 7 | Polymyositis | Congenital Myasthenic Syndrome | Charcot-Marie-Tooth Disease Type 3 | Antisynthetase Syndrome | Spinocerebellar Ataxia Type 12 | Toxoplasmosis | Hypertensive Retinopathy | Spinocerebellar Ataxia Type 21 | Lipodystrophy | Parkinsonism | Early Infantile Epileptic Encephalopathy 28 | Kearns-Sayre Syndrome | Thanatophoric Dysplasia Type 1 | B-cell Chronic Lymphocytic Leukemia | Schnitzler Syndrome | Endocarditis | Placenta Previa | Renal Failure | Atelosteogenesis Type 2 | Polydactyly | Gout | Aldosterone Synthase Deficiency | Batten Disease | Gastroenteritis | Neurofibromatosis Type 1 | Ganglioneuroma | Hyperostosis | Neutrophilia | Epithelial-myoepithelial Carcinoma | Huntington's Disease | Miyoshi Myopathy | Arteriovenous Malformations | Schamberg Disease | Bloom Syndrome | Oculopharyngeal Muscular Dystrophy | Pelizaeus-Merzbacher Disease | Neuromuscular Disorders | Omenn Syndrome | Beckwith-Wiedemann Syndrome | Homocystinuria | Granuloma Annulare | Infantile Liver Failure Syndrome 1 | Glycogen Storage Disease | Diabetes Type 1 | Hereditary Spherocytosis | Keratosis, Actinic | Heart Failure | Spinocerebellar Ataxia Type 8 | Cryoglobulinemia | Epidermolysis Bullosa Acquisita | Pseudohermaphroditism | Currarino Syndrome | CHARGE Syndrome | Pulmonary Tuberculosis | Congenital Hemolytic Anemia | Fibrosarcoma | Hereditary Sensory And Autonomic Neuropathy | Chronic Periodontitis | Glutathione Synthetase Deficiency | Metachondromatosis | Pemphigus Foliaceus | Sponastrime Dysplasia | Epithelioid Hemangioma | Usher Syndrome | Galactosemia | Schwartz-Jampel-Aberfeld Syndrome | Hypermethioninemia | Dystonia | Esophageal Carcinoma | Autosomal Recessive Spastic Paraplegia Type 75 | Syncope | Brenner Tumor | Dengue Shock Syndrome | Mitochondrial DNA Depletion Syndrome | Sclerocornea | Hyperparathyroidism-jaw Tumor Syndrome | Hypospadias | Richter's Syndrome | CDKL5 Deficiency Disorder | Epidermolysis Bullosa Simplex, Dowling-Meara Type | Oral Lichen Planus | Wieacker-Wolff Syndrome | Canavan Disease | Hypoproteinemia, Hypercatabolic | McLeod Syndrome | Turner's Syndrome | Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy | Acute Motor Axonal Neuropathy | Major Depression | Adrenoleukodystrophy, X-linked | Werner's Syndrome | Sarcomatoid Carcinoma Of The Lung | Hypoalbuminemia | Hemangioma | Heart Block | Aldosteronism | Chondrodysplasia Punctata | Hepatic Veno-occlusive Disease | Essential Fructosuria | Corneal Dystrophies, Hereditary | Benign Hereditary Chorea | Stroke, Hemorrhagic | Familial Male-limited Precocious Puberty | Heavy Chain Disease | Malonyl-CoA Decarboxylase Deficiency | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Cutis Laxa | Renal-hepatic-pancreatic Dysplasia | Milk Allergy | Adenoma, Pleomorphic | Cardiofaciocutaneous Syndrome | Hereditary Sensory Neuropathy Type 1 | Liebenberg Syndrome