MELAS Syndrome

About the Disease
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes, also known as melas syndrome, is related to mitochondrial myopathy and lactic acidosis, and has symptoms including myalgia, hemiparesis and ophthalmoplegia. An important gene associated with Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes is MT-ND6 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6), and among its related pathways/superpathways are "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." and Complex I biogenesis. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and heart, and related phenotypes are eeg abnormality and muscle weakness

Common Targets
MAOA | TRNS1 | PTGS1 | G7295 | COX3 | G23411 | DNA Topoisomerase II (nonspecified subtype) | TRNW | CYTB | XDH | PTPN1 | PPARD | Mitogen-Activated Protein Kinase (nonspecified subtype) | SUCLG2 | DGUOK | SCO1 | POLG | NF-kappaB (NFkB) | NDUFAF6 | ND3 | KCNQ1 | TRNT1 | LOXHD1 | SCN5A | NQO1 | Soluble guanylyl cyclase | ND5 | MYH7 | TRNL1 | KCNQ2 | TRNL2 | Calcium channel (nonspecified subtype) | PPARA | G5243 | COX2

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