Familial Mediterranean Fever

About the Disease
Familial Mediterranean Fever, also known as periodic fever syndrome, is related to autoinflammation, panniculitis, and dermatosis syndrome and brucellosis, and has symptoms including abdominal pain, arthralgia and fever. An important gene associated with Familial Mediterranean Fever is MEFV (MEFV Innate Immunity Regulator, Pyrin), and among its related pathways/superpathways are Innate Immune System and Disease. The drugs Interleukin 1 Receptor Antagonist Protein and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, b cells and kidney, and related phenotypes are nausea and vomiting and constipation

Common Targets
Interleukin-1 (nonspecified subtype) | IL1B | FAM161A | IL-1 Receptor (nonspecified subtype) | MVK | G114548 | ABCG5 | NLRP3 Inflammasome | ZNF200 | PTPN22 | CXCR2 | MEFV | IL6R | HLA-DRB1 | TNFRSF1A | IL1RN | SAA1 | HLA-B | G5243 | Tubulin | CYP2D6 | MMP3

Note: If you'd like to get a target analysis report for Familial Mediterranean Fever, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Familial Mediterranean Fever at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Spinal And Bulbar Muscular Atrophy | Congenital Tufting Enteropathy | REM Sleep Behavior Disorder | Poretti-Boltshauser Syndrome | Hypohidrotic Ectodermal Dysplasia | DOCK8 Immunodeficiency Syndrome | Asphyxia Neonatorum | Scoliosis | Mucolipidosis Type IV | Carcinoma, Transitional Cell | Urea Cycle Disorder | Anencephaly | Glycogen Storage Disease | Coffin-Siris Syndrome | Adenosine Deaminase Deficiency | Cardiac Sarcoidosis | Hypertension, Pulmonary | Cole-Carpenter Syndrome | Endometriosis | Multiple Sclerosis, Chronic Progressive | Hyperglycemia | Chromosome 8q21.11 Deletion Syndrome | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Uremia | Pericarditis | Spinal Muscular Atrophy Type 2 | Central Retinal Artery Occlusion | Angiomyolipoma | Hyperostosis | Hydrops Fetalis | Esophagitis | Borjeson-Forssman-Lehmann Syndrome | Left Ventricular Noncompaction | C3 Glomerulonephritis | Waardenburg Syndrome Type 2A | X-linked Acrogigantism | Anorexia Nervosa | Woodhouse-Sakati Syndrome | Brachydactyly | Bone Marrow Necrosis | Genitopatellar Syndrome | Urticaria | Feingold Syndrome | Split Hand-foot Malformation | Alexander Disease | Keratitis | Hypohidrotic Ectodermal Dysplasia, X-linked | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Leri Pleonosteosis | Esophagitis, Eosinophilic | Chronic Leukemia | Thalassemia, Beta | Nemaline Myopathy 10 | Polycystic Kidney, Autosomal Dominant | Currarino Syndrome | Anxiety Disorders | Wolfram Syndrome 2 | Arteriosclerosis | Congenital Sodium Diarrhea | Lipoma | Waardenburg Syndrome Type 1 | Sporadic Inclusion Body Myositis | Bronchitis | Osteomyelitis | Peritonitis | Phenylketonuria II | Progressive Familial Intrahepatic Cholestasis Type 2 | Basan Syndrome | CDKL5 Deficiency Disorder | Retinal Diseases | Uveitis | Sickle Cell Anemia | Alopecia Totalis | Hepatic Adenomatosis | Vestibular Disease | Menetrier Disease | Porokeratosis | Mitochondrial DNA Depletion Syndrome 13 | Stroke | Renal Tubular Acidosis | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Waardenburg Syndrome Type 4 | PASLI Disease | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Osteopathia Striata With Cranial Sclerosis | Arthritis, Gouty | Postpartum Depression | Acute Generalized Exanthematous Pustulosis | Coloboma | Glaucomatocyclitic Crisis | Dermatomyositis | Vasculitis | Hypogammaglobulinemia | Congenital Absence Of Vas Deferens | Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis | Cousin Syndrome | Tremor | Primary Aldosteronism | Hereditary Mixed Polyposis Syndrome | Paronychia | Trimethylaminuria | Colon Adenoma | Hereditary Inclusion Body Myopathy | Myofibrillar Myopathy | Diverticulitis | Leukocyte Adhesion Deficiency | Carcinoid Syndrome | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Fuchs Heterochromic Iridocyclitis | Retinal Detachment | Kleine-Levin Syndrome | Behavioral Variant Of Frontotemporal Dementia | Myocardial Infarction | Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress | Methemoglobinemia Type IV | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Combined Malonic And Methylmalonic Acidemia | Myocarditis | Cellulitis | Persistent Mullerian Duct Syndrome | Multiple Hamartoma Syndrome | Hypothyroidism | Sclerocornea | Chanarin-Dorfman Syndrome | Prolymphocytic Leukemia | Tracheal Disorders | Primary Progressive Aphasia | Juvenile Xanthogranuloma | Congenital Generalized Lipodystrophy | Robinow Syndrome | Canavan Disease | L-2-Hydroxyglutaric Aciduria | Costello Syndrome | Poikiloderma With Neutropenia | Eating Disorder | Mohr-Tranebjaerg Syndrome | GNE Myopathy | Retinopathy, Diabetic | Wiskott-Aldrich Syndrome | Citrullinemia | Lymphangioleiomyomatosis | Erythema Multiforme | Niemann-Pick Disease, Type B | Crouzon Syndrome With Acanthosis Nigricans | Androgenic Alopecia | Yellow Fever | Scleritis | Hypertrophy | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Discoid Lupus Erythematosus | Necrobiosis Lipoidica | Takayasu's Arteritis | Meningeal Melanocytoma | Benign Familial Infantile Seizures | TARP Syndrome | Lymphoproliferative Disorders | Holt-Oram Syndrome | Familial Hypobetalipoproteinemia | Alagille Syndrome | Astigmatism | Osteochondrosis | Esophageal Carcinoma | Diarrhea | Protein C Deficiency | Corneal Dystrophies, Hereditary | Familial Pheochromocytoma-paraganglioma | Primary Hyperoxaluria Type 3 | Acrocallosal Syndrome | Oculocutaneous Albinism Type 2 | Porencephaly | Perivascular Epithelioid Cell Tumor | Congenital Fiber-type Disproportion Myopathy | Localized Scleroderma | Shock, Cardiogenic | Antisocial Personality Disorder | Niemann-Pick Disease, Type A | Bardet-Biedl Syndrome | Nephronophthisis | Idiopathic Multicentric Castleman Disease | Endometrial Hyperplasia | Precocious Puberty | Apparent Mineralocorticoid Excess Syndrome | Chordoma | Erectile Dysfunction | Usher Syndrome Type III | DRESS Syndrome | Chronic Myeloid Leukemia | Erythema Nodosum | NGLY1 Deficiency | Presbycusis | Diabetes Insipidus | Chondroma | NDH Syndrome | Hyperkalemic Periodic Paralysis | Nail-Patella Syndrome | Allergic Contact Dermatitis | Ocular Hypertension | Periodontitis | Cerebellofaciodental Syndrome | Progressive Familial Intrahepatic Cholestasis | Glycogen Storage Disease Type 3 | Galactosialidosis | Pitt-Hopkins Syndrome | Hoyeraal-Hreidarsson Syndrome | Thyroid Dysgenesis | Mycosis Fungoides | Hypoproteinemia, Hypercatabolic | Metabolic Diseases | Megalencephaly | Congenital Stationary Night Blindness | Schuurs-Hoeijmakers Syndrome | Nemaline Myopathy | Acute Kidney Injury | Fahr Disease | Seasonal Mood Disorder | Trichorhinophalangeal Syndrome | Neovascular Glaucoma | Cleidocranial Dysplasia | Papillorenal Syndrome | Abetalipoproteinemia | Heart Septal Defects | Spinocerebellar Ataxia Type 27 | Marfan Syndrome | Priapism | Ileitis | ICF Syndrome | Johanson-Blizzard Syndrome | Diamond-Blackfan Anemia | Hyperinsulinemia | Cutaneous Angiosarcoma | Herpes Genitalis | Hypercalcemia | Familial Hypertrophic Cardiomyopathy | Chitayat Syndrome | X-linked Creatine Transporter Deficiency | Acrodermatitis | Glomerulonephritis, Membranoproliferative | Metabolic Syndrome | Autoimmune Hemolytic Anemia | Renal Failure | Leishmaniasis, Cutaneous | Glycogen Storage Disease Type 9 | Cardiomyopathy, Dilated, 1L | Galactosemia | Acne Vulgaris | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | B-cell Chronic Lymphocytic Leukemia | LEOPARD Syndrome | Exfoliative Dermatitis | Hyperferritinemia-cataract Syndrome | Oculodentodigital Dysplasia | Carcinoma, Small Cell | Histiocytosis | Spinocerebellar Ataxia Type 6 | Crimean-Congo Hemorrhagic Fever | Sepiapterin Reductase Deficiency | Anti-NMDA Receptor Encephalitis | Peroxisomal Disorder | Pyoderma Gangrenosum | Nijmegen Breakage Syndrome | Alopecia | Sertoli Cell-only Syndrome | Aldosteronism | Encephalopathy | Light Chain Amyloidosis | Chromosome 9q34.3 Deletion Syndrome | Hypodontia | Maternally Inherited Diabetes And Deafness | Multicentric Carpotarsal Osteolysis Syndrome | Avian Influenza | Meningioma, Benign | Olmsted Syndrome | Leiomyosarcoma | Scleroderma, Diffuse | Congenital Heart Defects | Senior-Loken Syndrome | Ectopia Lentis, Isolated, Autosomal Recessive | Martsolf Syndrome | Angiodysplasia | Non-epidermolytic Palmoplantar Keratoderma | Enlarged Vestibular Aqueduct | Chronic Granulomatous Disease | Superficial Spreading Melanoma | Pulmonary Tuberculosis | Leiomyoma | Birk-Barel Syndrome | Beta-Propeller Protein-associated Neurodegeneration | Onchocerciasis | Kohlschutter-Tonz Syndrome | Nevus | Adult Polyglucosan Body Disease | Oligodendroglioma | C3 Glomerulopathy | Multiple Sclerosis | Pleurisy | Muscle Wasting | Oculocutaneous Albinism Type 4 | Dysfibrinogenemia | Malonyl-CoA Decarboxylase Deficiency | Parapsoriasis | Marinesco-Sjogren Syndrome | Inflammatory Bowel Disease | Corneal Dystrophy | Aspartylglycosaminuria | Hemangioma | Charcot-Marie-Tooth Disease Type 4B1 | CREST Syndrome | Cardiomyopathy, Restrictive | Tyrosinemia Type 1 | Chronic Thromboembolic Pulmonary Hypertension | Kashin-Beck Disease | Carney-Stratakis Syndrome | Coronary Heart Disease | Carpal Tunnel Syndrome | Familial Hyperaldosteronism | Pseudohypoparathyroidism Type 1A | Mucormycosis | Gerodermia Osteodysplastica | Neurodegeneration With Brain Iron Accumulation | Charcot-Marie-Tooth Disease Type 4D | Ventricular Septal Defect | Methylmalonic Acidemia | Congenital Mirror Movements | Premature Ejaculation | Periventricular Leukomalacia | Adenoma, Pituitary | DEND Syndrome | Focal Facial Dermal Dysplasia | Giant Axonal Neuropathy | Endocarditis | Microvillus Inclusion Disease | Lichen Sclerosus | Sarcoma, Endometrial Stromal | Gray Platelet Syndrome | Rolandic Epilepsy | Carcinoma, Signet Ring Cell | Smith-Kingsmore Syndrome | Cryptococcal Meningitis | Glutaric Aciduria Type 1 | Ameloblastic Carcinoma | Congenital Dyserythropoietic Anemia | Hypertension | Amblyopia | Hepatic Steatosis | Familial Episodic Pain Syndrome | MELAS Syndrome | IMAGe Syndrome | Intermittent Explosive Disorder | KBG Syndrome | Spondylo-ocular Syndrome | Hepatorenal Syndrome | Neurofibroma, Plexiform | Dent Disease | Basal Cell Nevus Syndrome | Blepharo-cheilo-odontic Syndrome | Spinocerebellar Ataxia Type 16 | Goiter, Nodular | Lewy Body Dementia | Familial Exudative Vitreoretinopathy | Aneurysm, Abdominal Aortic | Sitosterolemia | Kaposiform Hemangioendothelioma | Schwannoma | Charcot-Marie-Tooth Disease, Type 1A | Schizophrenia | Glioma | Erysipelas | Situs Inversus | PHARC Syndrome | Long QT Syndrome Type 2 | Gardner Syndrome | Premenstrual Syndrome | Personality Disorders | Paraganglioma, Carotid Body | Charcot-Marie-Tooth Disease, Type 2 | Hepatitis, Autoimmune | Sweet Syndrome | Lupus Erythematosus | Intestinal Pseudo-obstruction | Lymphoma, Follicular | Eclampsia | Parkinsonism | Hereditary Sensory Neuropathy Type 1 | Osteoporosis | Dysferlinopathy | Carcinoma In Situ | Heimler Syndrome | Microphthalmia | Cholesteryl Ester Storage Disease | Bietti Crystalline Dystrophy | Ophthalmia, Sympathetic | Large Granular Lymphocytic Leukemia | Myoclonic Epilepsy With Ragged Red Fibers | Cannabis Abuse | Lipid Storage Myopathy | Greenberg Dysplasia | Spermatocele | Metaphyseal Chondrodysplasia, Schmid Type | Myotonic Disorders | Cystitis