Type 1A Charcot-Marie-Tooth Disease
Type 1A Charcot-Marie-Tooth Disease
About the Disease
Charcot-Marie-Tooth Disease, Demyelinating, Type 1a, also known as charcot-marie-tooth disease type 1a, is related to roussy-levy hereditary areflexic dystasia and charcot-marie-tooth disease, axonal, type 2a1. An important gene associated with Charcot-Marie-Tooth Disease, Demyelinating, Type 1a is PMP22 (Peripheral Myelin Protein 22), and among its related pathways/superpathways are Neural crest differentiation and Intracellular trafficking proteins involved in CMT neuropathy. The drugs Sorbitol and Naltrexone have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, tonsil and spinal cord, and related phenotypes are skeletal muscle atrophy and pes cavus
Common Targets
LITAF | Gamma-Aminobutyric acid type B receptor | PMP22 | MPZ | HDAC6 | OPRM1 | OPRK1 | MIR149
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