Alpers Syndrome

About the Disease
Mitochondrial Dna Depletion Syndrome 4a, also known as alpers syndrome, is related to mitochondrial dna depletion syndrome and polg-related disorders, and has symptoms including ataxia, myoclonus and vomiting. An important gene associated with Mitochondrial Dna Depletion Syndrome 4a is POLG (DNA Polymerase Gamma, Catalytic Subunit), and among its related pathways/superpathways are tRNA Aminoacylation and TP53 Regulates Metabolic Genes. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include liver, cortex and brain, and related phenotypes are ataxia and developmental regression

Common Targets
FARS2 | POLG | PPARA

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