Mitochondrial Disease

About the Disease
Mitochondrial Disease, also known as mitochondrial diseases, is related to mitochondrial metabolism disease and sensory ataxic neuropathy, dysarthria, and ophthalmoparesis. An important gene associated with Mitochondrial Disease is MT-ATP6 (Mitochondrially Encoded ATP Synthase Membrane Subunit 6), and among its related pathways/superpathways are "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins." and Complex I biogenesis. The drugs Atorvastatin and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include placenta, skeletal muscle and spinal cord.

Common Targets
COX2 | AIFM1 | YARS1 | FDXR | TOMM40 | TMEM70 | DRD2 | G4780 | NDUFB3 | TAMM41 | MRPS34 | RTN4IP1 | C1QBP | COX3 | TRNT | POLRMT | TPP1 | MPV17 | SLC6A2 | TRMU | DHODH | KEAP1 | ANO5 | G23411 | HTR2B | PLCL2 | ND1 | NDUFB9 | MTO1 | HCRTR1 | DNA2 | Glutamate Transporter (nonspecified subtype) | SPATA5 | MRPS22 | UQCRB | TWNK | PGAM5-KEAP1-NRF2 Complex | G3630 | ADRA2A | Nicotinic alpha4beta2 receptor | ND2 | DGUOK | MIR181B1 | OPRL1 | PNPLA8 | SUCLA2 | MPC1 | NDUFAF6 | 15-Lipoxygenase (nonspecified subtype) | SDHC | DRD1 | PINK1 | ADRB1 | POLG | NUBPL | HCRTR2 | FASN | NDUFAF3 | ND4 | ACMSD | MIR181A1 | ATP-dependent 6-phosphofructokinase (nonspecified subtype) | KARS1 | HTR1B | ATP6 | RMND1 | SDHD | USP30 | NAMPT | CACNA1A | HTR2C | MECR | TRMT10C | BCS1L | LETM1 | SSBP1 | SURF1 | ATP5F1B | NGLY1 | ALOX5 | SLC6A3 | SFXN4 | PMPCA | TIMM44 | DDX3X | VARS2 | BTD | TRIT1 | CHRNB2 | TRNL1 | IMMT | KIF1A | Soluble guanylyl cyclase | ATF5 | PPIE | ALOX15 | RRM2B | SAMM50 | PYROXD2 | ND6

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