Familial Hypercholesterolemia

About the Disease
Familial Hypercholesterolemia, also known as hyperlipoproteinemia type iia, is related to homozygous familial hypercholesterolemia and hyperlipoproteinemia, type iii. An important gene associated with Familial Hypercholesterolemia is LDLR (Low Density Lipoprotein Receptor), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Heparin, bovine and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include Liver, heart and eye, and related phenotypes are Increased free cholesterol and Increased LDL uptake

Common Targets
APOE | KLRC1 | SREBF1 | CETP | SPP1 | LPL | LRP6 | STAP1 | HSPB7 | G5243 | SREBF2 | NR2E1 | LDLR | ANP32E | CABP5 | APOA5 | SUGP1 | POR | THRB | NPC1L1 | KCTD7 | ANGPTL3 | DGAT2 | AMP-activated protein kinase (AMPK) | EPHX2 | PODXL | SCARB1 | SORT1 | RBM25 | Liver Bile Transporters (LBAT) (nonspecified subtype) | PUS3 | LIPA | TNNT2 | LDLRAP1 | G3569 | Peroxisome Proliferator-Activated Receptors (PPAR) (nonspecified subtype) | PCSK9 | DHCR7 | HMGCR | MYL2 | ABCA1 | CELSR2 | USF1 | ABCG5 | G7852 | CES1 | PPARD | SLC10A1 | DPP4 | INSIG2 | G7099 | MTTP | WDR89 | ABCG8 | CH25H | TSTD1 | CELA2B | MRO | ABCC6 | G9429 | TXNRD1 | G3630 | UBD | APOA1 | PON1 | MOAP1 | ACLY | FASLG | CXCR2 | PABPC1 | ROBO1 | LPA | MYH7 | APOB | ALB

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