Disease

Nephrosclerosis

About the Disease
Nephrosclerosis, also known as renal sclerosis, is related to malignant hypertension and pyelonephritis. An important gene associated with Nephrosclerosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Signal Transduction and TGF-Beta Pathway. The drugs Angiotensin II and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and heart, and related phenotypes are no effect and no effect

Common Targets
MEFV | APOL1

疾病靶点研报
Nephrosclerosis

Note: If you'd like to get a target analysis report for Nephrosclerosis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Nephrosclerosis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Cerebral Cavernous Malformations | Nephronophthisis | Polycythemia Vera | Cystitis | Sarcoidosis, Pulmonary | CDKL5 Deficiency Disorder | Autoimmune Polyendocrine Syndrome | Nicolaides-Baraitser Syndrome | Focal Facial Dermal Dysplasia | Diabetes Type 2 | Micropenis | Nasodigitoacoustic Syndrome | Cancer, Colon | Colorectal Adenoma | Hyperlipidemia | 5-oxoprolinase Deficiency | Guillain-Barre Syndrome | Congenital Tufting Enteropathy | Neurofibromatosis Type 2 | Glycogen Storage Disease Type 5 | Leukodystrophies | Autosomal Recessive Bestrophinopathy | Tinea Versicolor | Chylomicron Retention Disease | Osteochondrosis | Familial Pheochromocytoma-paraganglioma | Trichothiodystrophy | Glutaric Aciduria Type 2 | Alazami Syndrome | Urethritis | Leigh Syndrome | Trachoma | Adrenoleukodystrophy, X-linked | Pituitary Dwarfism | Atelosteogenesis Type 1 | Headache | Photosensitivity | Hypoalbuminemia | Erectile Dysfunction | Chronic Beryllium Disease | Lipid Metabolism Disorders | Glycogen Storage Disease | Hyperammonemia | Neuroendocrine Cancer | Melnick-Needles Syndrome | Multicystic Renal Dysplasia | Pitt-Hopkins Syndrome | Chromosome 9q34.3 Deletion Syndrome | Noonan Syndrome-like Disorder With Loose Anagen Hair | Niemann-Pick Disease | WAGR Syndrome | Anencephaly | Ichthyosis, X-linked | Early Infantile Epileptic Encephalopathy 4 | Phenylketonuria II | Pure Autonomic Failure | Hepatitis, Chronic | Multicentric Carpotarsal Osteolysis Syndrome | Neuroleptic Malignant Syndrome | Raynaud Phenomenon | Cholecystitis | AIDS Dementia Complex | Epidermodysplasia Verruciformis | Fragile X Syndrome | Pituitary Disorders | Congenital Primary Aphakia | Intestinal Pseudo-obstruction | Premenstrual Syndrome | Hyperlipidemia Type V | Dyslexia | Blue Rubber Bleb Nevus Syndrome | Congenital Adrenal Hyperplasia 1 | Postaxial Polydactyly | Persistent Hyperplastic Primary Vitreous | Parkinsonism | Spitz Nevus | Angina Pectoris | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Mucolipidosis | Granuloma Annulare | Robinow Syndrome | Sengers Syndrome | Glaucoma | Polycystic Kidney, Autosomal Dominant | Focal Segmental Glomerulosclerosis | Renal Tubular Dysgenesis | Bainbridge-Ropers Syndrome | Bronchiolitis | Waardenburg Syndrome Type 4 | Sarcoidosis | Cavitary Optic Disc Anomalies | Arterial Tortuosity Syndrome | Osteogenesis Imperfecta Type V | Vici Syndrome | Leukoencephalopathy, Progressive Multifocal | Raine Syndrome | Avellino Corneal Dystrophy | Pancytopenia | LRBA Deficiency | Anodontia | Portal Vein Thrombosis | Hypohidrotic Ectodermal Dysplasia, X-linked | Lyme Disease | Dengue Hemorrhagic Fever | Anemia | Pseudoachondroplasia | Liebenberg Syndrome | Retinitis Pigmentosa 3 | Steel Syndrome | Anosmia, Congenital | Uremic Pruritus | Charcot-Marie-Tooth Disease, Type 2A | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Diabetes Type 1 | Pituitary Stalk Interruption Syndrome | Stickler Syndrome | Cold-induced Sweating Syndrome | Phenylketonuria | Achondrogenesis | Becker Muscular Dystrophy | Seasonal Mood Disorder | Congenital Sodium Diarrhea | Frank-ter Haar Syndrome | FG Syndrome | Familial Hemiplegic Migraine | Colitis | Clouston Hidrotic Ectodermal Dysplasia | Lennox-Gastaut Syndrome | Coenzyme Q10 Deficiency | Rhabdoid Tumor | Primary Cutaneous Amyloidosis | Hydrocephalus, Normal Pressure | Combined Pituitary Hormone Deficiency | Neurodegeneration Due To Cerebral Folate Transport Deficiency | Tardive Dyskinesia | Carcinoma, Signet Ring Cell | Thrombotic Microangiopathy | CEDNIK Syndrome | Osteoporosis | CHOPS Syndrome | Autoimmune Autonomic Ganglionopathy | Diffuse Mesangial Sclerosis | Onchocerciasis | Lupus Erythematosus | Osteogenesis Imperfecta Type VI | Meningococcal Meningitis | Sensorineural Hearing Loss | Malignant Peripheral Nerve Sheath Tumor | Pleurisy | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Primary Torsion Dystonia | Pure Red Cell Aplasia | Glutathione Synthetase Deficiency | Xeroderma Pigmentosum Variant Type | Limb Girdle Muscular Dystrophy | Swine Influenza | Thrombocythemia, Essential | Chromosome 5q Deletion Syndrome | Autoimmune Polyendocrinopathy Syndrome Type I | Twin-to-twin Transfusion Syndrome | Senior-Loken Syndrome | Congenital Nephrotic Syndrome | Whipple's Disease | Alveolar Capillary Dysplasia | Acne Vulgaris | Eiken Syndrome | Low Phospholipid Associated Cholelithiasis | Spermatocele | Analgesia | Amyloidosis | Castleman Disease | Goldenhar Syndrome | Saethre-Chotzen Syndrome | Temtamy Preaxial Brachydactyly Syndrome | Pulverulent Zonular Cataract | Familial Hypertrophic Cardiomyopathy | Turner's Syndrome | Rheumatic Heart Disease | Communication Disorders | Colitis, Lymphocytic | Homocystinuria | VEXAS Syndrome | Olmsted Syndrome | Blue Nevus | Glioblastoma Multiforme | Spondylosis | Neurodegeneration With Brain Iron Accumulation | Neurofibroma, Plexiform | Babesiosis | Retinitis | Silver-Russell Syndrome | Seizures | C3 Glomerulonephritis | Glycogen Storage Disease Type 1a | Porphyria, Acute Intermittent | Ligneous Conjunctivitis | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Polyarteritis Nodosa | Dementia | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Hepatitis A | Hyperuricemia | Synovitis | Kawasaki Disease | Dentinogenesis Imperfecta | Myofibrillar Myopathy | Dysthymia | Osteogenesis Imperfecta | Progressive Familial Intrahepatic Cholestasis | Familial Advanced Sleep Phase Syndrome | Necrobiosis Lipoidica | Nail-Patella Syndrome | Prolidase Deficiency | Neuronal Ceroid Lipofuscinosis | Distal Myopathy 2 | Lymphoma Lymphoblastic | Rhizomelic Chondrodysplasia Punctata | Chorioretinitis | Charcot-Marie-Tooth Disease Type 4 | McKusick Type Metaphyseal Chondrodysplasia | Pseudohypoparathyroidism Type 1B | Hypervalinemia | Lymphedema | Cancer, Kidney | Venous Insufficiency | McLeod Syndrome | Precocious Puberty | Proteasome-associated Autoinflammatory Syndrome 2 | Esophagitis | Viral Meningitis | Renpenning Syndrome | Cold Agglutinin Disease | Bartsocas-Papas Syndrome | Exocrine Pancreatic Insufficiency | Schnyder Crystalline Corneal Dystrophy | Acute Myeloid Leukemia | Barrett Esophagus | Achromatopsia | Protein S Deficiency | Epithelioid Hemangioma | Neurocutaneous Melanocytosis | Niemann-Pick Disease, Type A | Carbamoyl Phosphate Synthetase I Deficiency | Conduct Disorder | Rheumatoid Arthritis | Neurofibromatosis | Vitreoretinal Degeneration, Snowflake Type | Hereditary Coproporphyria | Schizotypal Personality Disorder | Okihiro Syndrome | Chronic Leukemia | Carney Triad | Usher Syndrome Type III | Arthropathy | Polymyositis | Demyelinating Diseases | Hypothalamic Obesity | Pontocerebellar Hypoplasia Type 7 | Exfoliative Dermatitis | Hypercholesterolemia, Familial | Spinocerebellar Ataxia Type 5 | Esthesioneuroblastoma | Dysferlinopathy | Trichotillomania | Cramp Fasciculation Syndrome | Ocular Albinism Type 1 | Chromosome 17q21.31 Deletion Syndrome | Hidradenitis Suppurativa | Martsolf Syndrome | Thymoma, Malignant | Hyperoxaluria | Rothmund-Thomson Syndrome | Inflammatory Linear Verrucous Epidermal Nevus | Sezary Syndrome | Neural Tube Defect | Gout | Sclerosteosis | Antiphospholipid Syndrome | Mast Cell Leukemia | Hemophilia | Episodic Ataxia Type 1 | Takotsubo Cardiomyopathy | 3-methylglutaconic Aciduria Type IV | Barakat Syndrome | Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2 | Wieacker-Wolff Syndrome | Postpoliomyelitis Syndrome | Beckwith-Wiedemann Syndrome | Situs Inversus | Lung Diseases | Fibrosis | Tuberculous Meningitis | Thalassemia | Schistosomiasis | Omenn Syndrome | Hypermethioninemia | Sick Sinus Syndrome | Menetrier Disease | Hypertension, Pulmonary | Encephalitis | Glomerulonephritis, Membranous | Lichen Planus | Nevus | Roberts Syndrome | Essential Fructosuria | Vertigo | Papulopustular Rosacea | Acromesomelic Dysplasia | Sleep Apnea | Otitis Media | Gynecomastia | Glioma | Lymphoma, AIDS-related | Heavy Chain Disease | Aphasia | Metatropic Dysplasia | Neurogenic Bladder | Antisocial Personality Disorder | Gingivitis | Amyotrophic Lateral Sclerosis-parkinsonism-dementia Complex | Giant Cell Glioblastoma | Juvenile Hyaline Fibromatosis | Brenner Tumor | Spinocerebellar Ataxia Type 3 | Tangier Disease | Palsy, Cerebral | Congenital Muscular Dystrophy | Schwartz-Jampel-Aberfeld Syndrome | Myoclonus | Diabetes Gestational | Encephalopathy, Glycine | POEMS Syndrome | Hyperostosis | Histiocytic Sarcoma | Crigler-Najjar Syndrome | Schistosomiasis Mansoni | Dupuytren Disease | Nemaline Myopathy | Pneumonia, Bacterial | Leri Pleonosteosis | Cholera | Pfeiffer Syndrome | Osteogenesis Imperfecta Type III | Hyperuricemic Nephropathy, Familial Juvenile | Cri-du-chat Syndrome | Hereditary Hemorrhagic Telangiectasia Type 2 | Bartter Syndrome | Mitochondrial DNA Depletion Syndrome | Craniometaphyseal Dysplasia | Cryptococcal Meningitis | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Aplasia Cutis Congenita | Impulse Control Disorder | Restless Legs Syndrome | Incontinentia Pigmenti | Polycystic Ovary Syndrome | Anterior Segment Dysgenesis | Centronuclear Myopathy | Oculocutaneous Albinism | Paroxysmal Nocturnal Hemoglobinuria | Sialidosis Type I | Spinocerebellar Ataxia Type 7 | Combined Malonic And Methylmalonic Acidemia | Cataract | Sitosterolemia | Hyperphenylalaninemia | Pseudohypoaldosteronism | Pyruvate Dehydrogenase Deficiency | Spinocerebellar Ataxia | Nijmegen Breakage Syndrome | Hepatitis | 3-hydroxy-3-methylglutaryl-CoA Synthase Deficiency | Renal Medullary Carcinoma | Galloway-Mowat Syndrome | Acromegaly | Pseudomyxoma Peritonei | Osmotic Demyelination Syndrome | Proximal Symphalangism | Epilepsy Of Infancy With Migrating Focal Seizures | Epiphyseal Chondrodysplasia, Miura Type | Toxoplasmosis | Colitis, Collagenous | Molybdenum Cofactor Deficiency | Nemaline Myopathy 10 | Spondylocostal Dysostosis | Glutaric Aciduria Type 1 | Glycogen Storage Disease Type 0, Muscle | Narcolepsy | COACH Syndrome | Alkaptonuria | Cardiofaciocutaneous Syndrome | Small Lymphocytic Lymphoma | Stroke, Hemorrhagic | Hypotrichosis | Diabetes Insipidus | Dubin-Johnson Syndrome | Dominant Optic Atrophy | Herpes Genitalis | Esophageal Adenocarcinoma | Polymyalgia Rheumatica