Sclerosing Cholangitis

About the Disease
Cholangitis, Primary Sclerosing, also known as primary sclerosing cholangitis, is related to portal hypertension and autoimmune pancreatitis, and has symptoms including icterus An important gene associated with Cholangitis, Primary Sclerosing is SEMA4D (Semaphorin 4D), and among its related pathways/superpathways is Defensins. The drugs Vancomycin and Bezafibrate have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and thyroid, and related phenotypes are autoimmunity and portal hypertension

Common Targets
TGFB1 | GPBAR1 | FFAR4 | GPR35 | ABI3 | MIR4435-2HG | PPARA | HLA-B | G4780 | PNPLA3 | ITGB1 | G7157 | HLA-DRB1 | MAP3K5 | ABCB4 | HDAC7 | PPARG | Integrin Receptor (nonspecified subtype) | TCF4 | ATP8B1 | NOTCH4 | CCDC88B | CD14 | HLA-A | LOC105377891 | FOXP1 | MMEL1 | GIPR | G4318 | UBASH3A | SOCS3 | BACH2 | NR1H4 | DDIT4 | SGSM1 | MME | HNRNPUL1 | MMP2 | CCR9 | SIK2 | NCR3 | CLEC16A | STK4 | HLA-DRB3 | Integrin alphavbeta6 receptor | TNFAIP6 | DCDC2 | SLC10A2 | SSTR5 | LINC00548 | CD28 | FUT2 | SH2B3 | Integrin alphavbeta1 | ABCB11 | TANGO6 | PRKD2 | MANBA | HLA-C | INPP5A | GLP1R | MST1 | PPARGC1A | HLA-DQB1 | IL23R | AOC3 | KIR2DS4 | GCGR | CD226

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