Insulin Resistance

About the Disease
Type 2 Diabetes Mellitus, also known as insulin resistance, is related to diabetes mellitus and maturity-onset diabetes of the young, type 8, with exocrine dysfunction, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Type 2 Diabetes Mellitus is IRS1 (Insulin Receptor Substrate 1), and among its related pathways/superpathways are Nervous system development and Angiopoietin-like protein 8 regulatory pathway. The drugs Glipizide and Glycopyrronium have been mentioned in the context of this disorder. Affiliated tissues include Pancreas and Adipose, and related phenotypes are type ii diabetes mellitus and insulin resistance

Common Targets
PASK | GPR119 | STEAP4 | PPARG | IL37 | NR1H2 | CNR1 | DGAT1 | FFAR1 | SERPINA6 | PNPLA3 | NAT2 | PAX6-AS1 | GRB14 | ADIPOQ | Estrogen receptor (nonspecified subtype) | NOD1 | ACP1 | ACHE | NR1H3 | SCD | GCK | IRS2 | CDKAL1 | MTHFR | KLB | UGCG | PIK3R1 | HSD11B1 | FGF21 | C11orf65 | G3630 | FGFR1 | USP19 | DPP4 | ABCG1 | PPARD | KHK | BACE2 | VDR | LEP | PCSK9 | PTTG1 | PTPN1 | GSK3B | NPY2R | INSR | RBP4 | NR1H4 | APOC3 | DACH1 | IRAK4 | PYGB | HHIPL1 | Casein kinase II (CKII) | TSC22D4 | Mitogen-Activated Protein Kinase (nonspecified subtype) | GIPR | BAD | MC3R | MAPKAPK2 | IL27 | RARB | ABCC8 | KCNMB3 | LOC157273 | GNRHR | SLC10A6 | ELAPOR1 | NMDA receptor | LIPC | GNPDA1 | Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) (nonspecified subtype) | LEPR | AGTR1 | ADAMTS9-AS2 | PIP4K2C | PIM1 | GNAS | VHL | PON1 | STK33 | SLC5A1 | MIR181A1 | PROKR1 | MSMO1 | ENPP1 | SGMS2 | SSTR5 | MSTN | ACACB | ADIPOR2 | G7124 | AGTR2 | GATA3 | IFNL4 | CCL2 | ECE1 | FTO | GLP1R | CMKLR1 | GPC6 | TRIB3 | ATP-Binding Cassette (ABC) Transporter (nonspecified subtype) | Sterol Regulatory Element-Binding Protein (nonspecified subtype) | CIDEC | GMFB | RARG | APLN | CRP | CYP11B2 | IL1R2 | PDGFA | TCF7L2 | SLC30A8 | IDE | CYP27B1 | ACACA | RXFP4 | SIRT3 | ERP44 | MBOAT4 | AMP-activated protein kinase (AMPK) | MC1R | PDE3A | SLC2A4 | GAS6 | GCGR | HLA-DRB1 | ELANE | CSF1R | ELOVL6 | CDH13 | LDLR | SLC5A2 | GPBAR1 | KCNJ11 | Acetyl-CoA Carboxylases (ACC) (nonspecified subtype) | FFAR4 | TACR2 | F2RL1 | PPARA

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