Disease

Focal Segmental Glomerulosclerosis

About the Disease
Focal Segmental Glomerulosclerosis, also known as familial idiopathic steroid-resistant nephrotic syndrome, is related to focal segmental glomerulosclerosis 2 and focal segmental glomerulosclerosis 5. An important gene associated with Focal Segmental Glomerulosclerosis is NPHS1 (NPHS1 Adhesion Molecule, Nephrin), and among its related pathways/superpathways are Cell junction organization and Nephrotic syndrome. The drugs Dapagliflozin and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include Kidney, bone marrow and bone, and related phenotypes are no effect and no effect

Common Targets
G1432 | G3630 | G7124 | ECT2 | TTC21B | MDK | COL4A5 | PPP3R2 | TRPC5 | MYO9A | PAX2 | HMOX2 | PPP3CC | NXF5 | NPHP4 | CCR2 | XDH | NPHS2 | CD40 | MAPK11 | Tyrosine Kinase (nonspecified subtype) | CCN2 | COQ8B | SERPINE1 | LAMB2 | CD2AP | CTLA4 | ARHGAP24 | NF-kappaB (NFkB) | Mitogen-Activated Protein Kinase (nonspecified subtype) | PODXL | PLCE1 | SYNPO | MS4A1 | AGTR1 | ACTN4 | TRPC6 | Heme Oxygenase (HO) (nonspecified subtype) | TGFB2 | LMX1B | CHUK | Transforming growth factor beta (nonspecified subtype) | WT1 | PON1 | HLA-DQB1 | TGFB1 | Integrin alphavbeta6 receptor | C3 | PPP3CB | G596 | PPP3R1 | CFH | CCL2 | APOL1 | CYP11B2 | TBC1D8B | HMOX1 | COL4A3 | PLA2R1 | HLA-DRB1 | CRB2 | Integrin alphavbeta1 | G4780 | MYO1E | PDSS2 | EDNRA | TGFB3 | RCAN1 | ANLN | COL4A4 | PPARG | Protein Phosphatase 2B | CD46 | INF2 | TRPC3 | PTPRO | CNR1 | TRIM8 | HLA-DQA1 | LAMA5 | GSR | MYH9 | SMARCAL1 | NPHS1 | NUP107 | TRPC4

疾病靶点研报
Focal Segmental Glomerulosclerosis

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