Myelofibrosis

About the Disease
Myelofibrosis, also known as primary myelofibrosis, is related to acute megakaryocytic leukemia and thrombocytosis. An important gene associated with Myelofibrosis is MPL (MPL Proto-Oncogene, Thrombopoietin Receptor), and among its related pathways/superpathways are TGF-Beta Pathway and Response to elevated platelet cytosolic Ca2+. The drugs Panobinostat and Lactitol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, myeloid and bone, and related phenotypes are fatigue and anemia

Common Targets
IKZF1 | IDH1 | G9429 | CCND2 | HAMP | RARA | UMODL1 | PIK3CB | CTNNA1 | G3845 | G598 | IRF1 | NPM1 | PRMT5 | Inhibitor of Apoptosis Proteins (IAPs) (nonspecified subtype) | BRD2 | Hedgehog Protein (nonspecified subtype) | G7124 | PHF6 | ENG | NAE1 | SYK | GATA1 | NTRK1 | LOX | PTCH1 | Tyrosine Kinase (nonspecified subtype) | CSF3R | SF3B1 | FLT3 | ETV6 | GSK3B | SMC1A | RET | HPGD | Reverse transcriptase (Telomerase) | HSF1 | TET2 | G4193 | G7015 | PIM3 | G4170 | SELP | XPO1 | TIMM50 | IL3RA | G7157 | SUZ12 | G2033 | ACVR2A | GATA2 | PDGFRA | GLS | JAK2 | DCX (DDB1-CUL4-X-box) E3 protein ligase complex | MECOM | SETBP1 | KMT2A | NF1 | KIT | LOXL1 | VHL | TNFAIP3 | IDH2 | ACVR1 | JAK3 | HDAC4 | JAK1 | CBL | BCORL1 | BCL2A1 | KDM1A | TGFB2 | BCOR | MIR146A | NEDD8-activating enzyme E1 | CSNK1A1 | Transforming growth factor beta (nonspecified subtype) | CRBN | PIM1 | PTPN11 | CREBBP | CYP2C9 | APCS | TXNRD1 | Janus Kinase (nonspecified subtype) | S100A9 | BRD3 | TRIM59 | LOXL2 | MIF | CD33 | TGFB1 | MPL | SLC40A1 | G596 | HAVCR2 | BCL2L2 | EEF1A2 | SF3A1 | ABL1 | RUNX1 | PIK3CG | CBLC | PBRM1 | G238 | VPS45 | CCL2 | G2146 | ZRSR2 | CDH3 | MYB | LRRC15 | LOXL4 | CTCF | NUP98 | SLCO2A1 | SH2B3 | IRAK1 | CDK1 | TGFBR2 | GCAT | LOXL3 | FGF2 | CALR | PDGFRB | CSF1R | NRAS | Dual Specificity Mitogen-Activated Protein Kinase Kinase (MEK) (nonspecified subtype) | ARHGAP45 | AURKA | G5347 | HCFC1 | TGFB3 | SMC3 | IFNAR2 | CDH23 | RGMA | PHLPP1 | HJV | DNA Methyltransferase (DNMT) (nonspecified subtype) | PIK3CA | CDK2 | STAG2 | MTHFR | SMO | TYK2 | G5243 | U2AF1 | Heat shock protein 90 (nonspecified subtype) | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | DNAH9 | PIM2 | NR3C1 | ASXL1 | SHKBP1 | CSNK1E | DNMT3A | PIK3CD | BRD4 | MAP2K1 | INSL6 | G4851 | PDGFB

Note: If you'd like to get a target analysis report for Myelofibrosis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Myelofibrosis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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