Multiple Hamartoma Syndrome

About the Disease
Cowden Syndrome 1, also known as bannayan-riley-ruvalcaba syndrome, is related to cowden syndrome and juvenile polyposis syndrome, and has symptoms including seizures, action tremor and cerebellar ataxia. An important gene associated with Cowden Syndrome 1 is PTEN (Phosphatase And Tensin Homolog), and among its related pathways/superpathways are ERK Signaling and Disease. The drugs Everolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include cerebellum, thyroid and skin, and related phenotypes are macrocephaly and nausea and vomiting

Common Targets
PIK3CA | G1956 | SEC23B | SDHB | KLLN | AKT2 | SDHD | USF3 | CHEK2 | AKT3 | G5728 | G207 | RASAL1

Note: If you'd like to get a target analysis report for Multiple Hamartoma Syndrome, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Multiple Hamartoma Syndrome at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Familial Advanced Sleep Phase Syndrome | Spasticity | Spinocerebellar Ataxia Type 2 | Neurocutaneous Melanocytosis | Microphthalmia | Pain | Nicolaides-Baraitser Syndrome | Corneal Dystrophy And Perceptive Deafness | Mitochondrial Disease | Acromicric Dysplasia | Adenomatoid Tumor | Conjunctivitis, Allergic | Niemann-Pick Disease, Type B | McKusick Type Metaphyseal Chondrodysplasia | Porphyria Cutanea Tarda | Meningioma, Benign | Mitochondrial DNA Depletion Syndrome, Myopathic Form | Osteonecrosis | Cholelithiasis | Schnitzler Syndrome | Fanconi Syndrome | Cranial Nerve Disease | Conduct Disorder | Seizures | Hypertension, Pulmonary | Adenosine Deaminase Deficiency | Urolithiasis | Chronic Lymphocytic Leukemia | Auriculocondylar Syndrome | Neuroendocrine Cancer | Oguchi Disease-2 | Albinism | Myocarditis | Hereditary Xerocytosis | Cornelia De Lange Syndrome | Early Infantile Epileptic Encephalopathy 28 | Aspartylglycosaminuria | Spondylolisthesis | Hepatitis B, Chronic | Spinocerebellar Ataxia Type 21 | Diffuse Mesangial Sclerosis | Coronary Heart Disease | Chronic Beryllium Disease | CREST Syndrome | Spondylometaphyseal Dysplasia | Hermansky-Pudlak Syndrome | Neurofibroma, Plexiform | Peutz-Jeghers Syndrome | Charcot-Marie-Tooth Disease Type 4E | Ovarian Hyperstimulation Syndrome | Thrombotic Microangiopathy | Myoclonus | Colitis | Sickle Cell Anemia | Larsen Syndrome | Microcephaly, Seizures, And Developmental Delay | Neutropenia | Renal-hepatic-pancreatic Dysplasia | Distal Myopathy 2 | Schizencephaly | Varices | Leri-Weill Dyschondrosteosis | Crigler-Najjar Syndrome | Majeed Syndrome | Angiodysplasia | Gastroschisis | Tuberculous Meningitis | Immunoproliferative Disorders | Wolff-Parkinson-White Syndrome | Borjeson-Forssman-Lehmann Syndrome | Scleritis | Acute Coronary Syndrome | Non-proliferative Diabetic Retinopathy | Craniopharyngioma | Saul-Wilson Syndrome | Oligospermia | Aspergillosis | Dent Disease | Schindler Disease | Sensory Neuropathy | Benign Familial Pemphigus | Blepharophimosis Syndrome | Keratosis | Dermatofibrosarcoma | Cerebral Amyloid Angiopathy | Split Hand-foot Malformation | Sponastrime Dysplasia | Osteoporosis, Postmenopausal | Myofibromatosis | Plasma Cell Leukemia | Chondrodysplasia Punctata 2, X-linked Dominant | Low Tension Glaucoma | Dystonia Musculorum Deformans | Splenomegaly | Cholera | Osteoarthritis | Zimmermann-Laband Syndrome | Hemolytic Uremic Syndrome | Pelizaeus-Merzbacher Disease | Milk Allergy | Stomatitis | Multiple Myeloma | Anterior Segment Dysgenesis | Nephropathy | High Molecular Weight Kininogen Deficiency | Erectile Dysfunction | Pseudohypoparathyroidism Type 1B | Richter's Syndrome | Nephronophthisis | N-acetylglutamate Synthase Deficiency | Periodic Limb Movement Disorder | Sengers Syndrome | Congenital Poikiloderma | VACTERL/VATER Association | Otosclerosis | Macrophage Activation Syndrome | Liver Diseases | VACTERL Association | T-cell Prolymphocytic Leukemia | Ventricular Septal Defect | Homocystinuria | Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3 | Addison Disease | Anorectal Malformations | Ganglioglioma | DEND Syndrome | Charcot-Marie-Tooth Disease, Type 6 | Fibrosis | Cerebrovascular Disorders | Non-epidermolytic Palmoplantar Keratoderma | Lattice Corneal Dystrophy Type 1 | Cryptorchidism | Measles | Cardiomyopathy, Dilated, 1L | Gout | Gastroenteritis, Eosinophilic | Hypoparathyroidism | Hemolytic Uremic Syndrome, Atypical | Primary Ovarian Insufficiency | Cold Agglutinin Disease | Arthritis, Reactive | CDKL5 Deficiency Disorder | Parkinsonism | Spinocerebellar Ataxia Type 16 | Epilepsy Of Infancy With Migrating Focal Seizures | Pseudohypoparathyroidism Type 1A | Progressive Familial Intrahepatic Cholestasis Type 2 | Eosinophilic Asthma | Familial Thoracic Aortic Aneurysm | Myositis | MELAS Syndrome | Uterine Leiomyoma | Silver-Russell Syndrome | Paraganglioma, Carotid Body | Teratozoospermia | Congenital Myasthenic Syndrome | Combined Deficiency Of Factor V And Factor VIII | GAPO Syndrome | Syphilis | Common Variable Immunodeficiency | Cannabis Abuse | Actinomycetoma | Apparent Mineralocorticoid Excess Syndrome | Vitamin B12 Deficiency | Long QT Syndrome Type 2 | Tyrosinemia Type 1 | Acrodysostosis | Endocarditis | Growth Hormone Excess | Craniometaphyseal Dysplasia | Harlequin Ichthyosis | Glioblastoma | Atrial Septal Defect | Plasmacytoma | Pemphigoid | Neuroleptic Malignant Syndrome | Carbonic Anhydrase VA Deficiency | Cryoglobulinemia | Glycogen Storage Disease Type 0, Muscle | Hypopigmentation | Ghosal Syndrome | Motion Sickness | Progressive Encephalopathy-optic Atrophy Syndrome | 3-M Syndrome | Goiter, Nodular | Lichen Sclerosus | Situs Inversus | Primary Cutaneous Amyloidosis | Insulin Resistance | Pycnodysostosis | Joubert Syndrome | Congenital Nephrotic Syndrome | Peeling Skin Syndrome Type B | Fetal Alcohol Syndrome | Acute Kidney Injury | Protein C Deficiency | Acute Tubular Necrosis | Zygomycosis | Melanoma, Uveal | Cenani-Lenz Syndactyly Syndrome | Hyperphenylalaninemia | Tatton-Brown-Rahman Syndrome | Kashin-Beck Disease | Nephroblastoma | Polyneuropathy | Tinea | Angioedema, Acquired | Sclerosteosis 2 | Personality Disorders | Alopecia | Cherubism | Hereditary Pyropoikilocytosis | Behcet's Disease | Epithelial-myoepithelial Carcinoma | Hypertelorism | Hemophilia | Pulmonary Veno-occlusive Disease | Oculocutaneous Albinism | Liebenberg Syndrome | Pontocerebellar Hypoplasia Type 7 | Raynaud Phenomenon | Seborrheic Dermatitis | Gitelman Syndrome | Sclerosteosis | Unverricht-Lundborg Syndrome | Donnai-Barrow Syndrome | Antley-Bixler Syndrome | Adenoma, Pituitary | Gastric Atrophy | Sarcoma | Coffin-Siris Syndrome | Peritonitis | Oculocutaneous Albinism Type 2 | Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2 | Encephalitis, Tick-borne | Distal Spinal Muscular Atrophy | Odonto-onycho-dermal Dysplasia | Congenital Dyserythropoietic Anemia Type 4 | Melanoma, Malignant | Meningioma | Hypercholesterolemia, Familial | Sick Sinus Syndrome | DiGeorge Syndrome | Arthropathy | Osteogenesis Imperfecta Type VI | Aldosterone Synthase Deficiency | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Essential Fructosuria | X-linked Sideroblastic Anemia | Encephalopathy, Glycine | Alkaptonuria | Usher Syndrome Type III | Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies | Congenital Dyserythropoietic Anemia | Chronic Periodontitis | Spondylocostal Dysostosis | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Spinocerebellar Ataxia Type 38 | Corneal Neovascularization | Microphthalmia, Syndromic 7 | Paraplegia | Keratoacanthoma | Arts Syndrome | Pituitary Disorders | Diabetes Type 1 | C3 Glomerulonephritis | Neurocysticercosis | Leishmaniasis, Cutaneous | Toxoplasmosis | Congestive Heart Failure | Large Granular Lymphocytic Leukemia | Purpura | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Sleep Disorder | DNA Ligase IV Deficiency | Iron Deficiency Anemia | Paronychia | Cardiac Arrest | Charcot-Marie-Tooth Disease, Type 2C | Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss | Hyperammonemia | Lyme Disease | Lymphopenia | Encephalopathy, Ethylmalonic | Schizotypal Personality Disorder | Hepatoblastoma | Fuchs Heterochromic Iridocyclitis | Xeroderma Pigmentosum Variant Type | Familial Mediterranean Fever | Perry Syndrome | Wolcott-Rallison Syndrome | Infertility | Benign Familial Neonatal Convulsions | Pleomorphic Xanthoastrocytoma | Macular Degeneration | Antiphospholipid Syndrome | Hypothyroidism | Tic Disorder | Spinocerebellar Ataxia Type 12 | Lymphoma, Follicular | Pneumothorax | Thyrotoxic Periodic Paralysis | Dowling-Degos Disease | Erythromelalgia | Phenylketonuria | Syndactyly | Anorchia | Spinocerebellar Ataxia Type 14 | Neurofibromatosis-Noonan Syndrome | Blastomycosis | Gestational Trophoblastic Disease | Amyotrophic Lateral Sclerosis | Colitis, Lymphocytic | Adrenomyeloneuropathy | Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form | Mountain Sickness | Herpes Simplex Dermatitis | Glucagonoma | Sialoadenitis | Familial Hypobetalipoproteinemia | Barakat Syndrome | Retinal Dystrophy | Moyamoya Disease | Pulmonary Sclerosing Hemangioma | Keratosis, Seborrheic | Carney-Stratakis Syndrome | Bare Lymphocyte Syndrome | Vascular Cognitive Impairment | Cancer, Kidney | Photosensitivity | Low Phospholipid Associated Cholelithiasis | Melanoma | Bloom Syndrome | Isovaleric Acidemia | Irritable Bowel Syndrome | Eccrine Porocarcinoma | Kernicterus | Hyperparathyroidism, Secondary | Chronic Neutrophilic Leukemia | Pseudohermaphroditism | Multisystemic Smooth Muscle Dysfunction Syndrome | Corneal Edema | Fibrodysplasia Ossificans Progressiva | Temtamy Preaxial Brachydactyly Syndrome | Spinocerebellar Ataxia Type 15 | Cancer, Brain | Hereditary Spastic Paraplegia | Fatty Aldehyde Dehydrogenase Deficiency | Charcot-Marie-Tooth Disease Axonal Type 2N | Chromosome 5q Deletion Syndrome | Birt-Hogg-Dube Syndrome | Nephrosclerosis | Asplenia | Pseudomyxoma Peritonei | Partington Syndrome | Scleroderma | Autosomal Recessive Spastic Paraplegia Type 35 | Major Depression | Ocular Surface Squamous Neoplasia | Urticaria | Osteochondrosis | Keratocystic Odontogenic Tumor | Hypotrichosis | Metatropic Dysplasia | Chorioretinitis | Osteopetrosis | Lymphangiomatosis | Vaginitis | Lymphoproliferative Disease, X-linked | Persistent Mullerian Duct Syndrome | Hepatic Veno-occlusive Disease | Leukoencephalopathy, Progressive Multifocal | ICF Syndrome | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Pearson Syndrome | Polymyositis | Acute Chest Syndrome | Nephrocalcinosis | Pyruvate Dehydrogenase Deficiency | Camurati-Engelmann Disease | Carcinoid Syndrome | Guillain-Barre Syndrome | Stuve-Wiedemann Syndrome | Disseminated Intravascular Coagulation | Osteomalacia | Fanconi Anemia | Leiomyosarcoma | Chronic Leukemia | Hyperbilirubinemia, Neonatal | Pneumonia, Mycoplasma | Fibrillation, Atrial | Neovascular Glaucoma | Nutrition Disorders | Intermittent Claudication | Lewy Body Dementia | Asperger Syndrome | Weill-Marchesani Syndrome | Ganglioneuroma | Wilson's Disease | Aromatic L-amino Acid Decarboxylase Deficiency